A5081400345- Immunotherapy and Immune Responses
- Psoriasis: Treatment and Pathogenesis
- Cutaneous lymphoproliferative disorders research
- Immune Cell Function and Interaction
- Neurofibromatosis and Schwannoma Cases
- Cancer Immunotherapy and Biomarkers
- Cancer Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Genital Health and Disease
- CAR-T cell therapy research
- Neuroblastoma Research and Treatments
- Sarcoma Diagnosis and Treatment
- T-cell and B-cell Immunology
- Hepatitis B Virus Studies
- Skin and Cellular Biology Research
- Vascular Malformations and Hemangiomas
- Nonmelanoma Skin Cancer Studies
- Autoimmune Bullous Skin Diseases
- Cutaneous Melanoma Detection and Management
- Urologic and reproductive health conditions
- Autoimmune and Inflammatory Disorders Research
- Virus-based gene therapy research
- Dermatology and Skin Diseases
- Management of metastatic bone disease
- Hair Growth and Disorders
Rockefeller University
2020
Icahn School of Medicine at Mount Sinai
2010-2019
Phelps Hospital
2016
NYU Langone Health
2013-2016
Albert Einstein College of Medicine
2010-2013
Immune suppressed organ transplant recipients suffer increased morbidity and mortality from primary cutaneous SCC. We studied tumor microenvironment in transplant-associated SCC (TSCC), immune-competent normal skin by IHC, IF RT-PCR on surgical discard. determined T cell polarization TSCC intracellular cytokine staining of crawl outs human explants. the effects IL-22, an inducer keratinocyte proliferation, proliferation vitro. are both associated with significantly higher numbers CD3+ CD8+...
Immune-suppressed organ transplant recipients (OTRs) can develop catastrophic squamous cell carcinoma (SCC), characterized by multiple primary tumors, extensive body surface area involvement, or metastases. There are currently no curative systemic therapies available. We previously showed that IL-22 enhances SCC proliferation. Herein, we examined links between cyclosporine (CSA), IL-22, and in patients, lines, mice with UV light-induced SCC. Eighteen of 114 OTRs developed SCC, which was...
Acquired digital fibrokeratoma is a rare benign fibroepithelial tumor that typically presents as solitary asymptomatic nodule on the finger or toe. Middle-aged adults are most commonly affected. Here we discuss an unusual case of acquired presenting cluster multiple nodules sole 15-year-old boy.
Physician rating of cutaneous erythema is central to clinical dermatological assessment as well quantification outcome measures in trials a number dermatologic conditions. However, issues with inter-rater reliability and variability the setting higher Fitzpatrick skin types make visual unreliable. We developed validated computer-assisted image-processing algorithm (EQscore) reliably quantify (across range types) dermatology setting. Our image processing evaluated based upon green light...
External genital warts (EGW) are currently the most common form of viral sexually transmitted disease found in general population. EGW have been shown to occur as a direct result infection with human papillomavirus (HPV). Malignancy is typically associated high-risk types HPV; however, low-risk type association has observed. Numerous therapies presently indicated for use treatment EGW, which can target lesions through multiple modalities including topically, surgically or via immune...
Palmoplantar psoriasis is a chronic disabling condition characterized by erythematous scaly plaques of the palms and soles, often with associated pain, erythema, fissuring. It thought to occur in up 40% patients, can at times be sole manifestation disease. This poses unique therapeutic challenge that it refractory many therapies currently approved for management psoriasis. Recently, apremilast, phosphodiesterase-4 inhibitor, became first small molecule psoriatic arthritis. While showing...
Cytokeratins are a major component of colloid bodies that essentially diagnostic lichen planopilaris (LPP). Here, the authors assess ability cytokeratin 903 antibody (CK-903) to stain and differentiate LPP from other histologically similar appearing primary cicatricial alopecias. A retrospective review all specimens submitted dermatopathology department over 2-year window identified 18 cases 20 entities (discoid lupus erythematosus or central centrifugal alopecia) through combination H&E,...
Department of Dermatology, Icahn School Medicine, New York, York The authors have indicated no significant interest with commercial supporters.