A5068682755- Urological Disorders and Treatments
- Nitric Oxide and Endothelin Effects
- Urinary Bladder and Prostate Research
- Immunotherapy and Immune Responses
- Surgical Sutures and Adhesives
- Kidney Stones and Urolithiasis Treatments
- Tissue Engineering and Regenerative Medicine
- Pediatric Urology and Nephrology Studies
- Ureteral procedures and complications
- Eicosanoids and Hypertension Pharmacology
- Inflammatory mediators and NSAID effects
- Laser Applications in Dentistry and Medicine
- Nonmelanoma Skin Cancer Studies
- Renal and Vascular Pathologies
- Veterinary Medicine and Surgery
- Hormonal and reproductive studies
- Sexual Differentiation and Disorders
- Cancer Immunotherapy and Biomarkers
- Chronic Kidney Disease and Diabetes
- Hormonal Regulation and Hypertension
- Virus-based gene therapy research
- Renal and related cancers
- Birth, Development, and Health
- RNA Interference and Gene Delivery
- Genital Health and Disease
Weill Cornell Medicine
2016-2020
Cornell University
2009-2020
NewYork–Presbyterian Hospital
1999-2018
New York Hospital Queens
2000-2018
Center for Children
2016-2017
New York Proton Center
2010-2016
Arthur Smith Institute for Urology
2014
Rockefeller University
2012
NYU Langone Health
2012
University of Missouri
2010
<h3>Importance</h3> Limited therapies are available in patients with inoperable locally advanced cutaneous squamous cell carcinoma (cSCC). <h3>Objective</h3> To determine the efficacy of programmed death 1 receptor (PD-1) inhibitors cSCC. <h3>Design, Setting, and Participants</h3> A single patient cSCC who declined surgery radiotherapy underwent treatment pembrolizumab, an anti–PD-1 antibody, at academic dermatologic section cancer center. The was followed up for clinical radiologic...
Iatrogenic injury to the healthy ureter during ureteroscope-guided ablation of malignant or nonmalignant disease can result in ureteral stricture. Transforming growth factor (TGF)-β
Immune suppressed organ transplant recipients suffer increased morbidity and mortality from primary cutaneous SCC. We studied tumor microenvironment in transplant-associated SCC (TSCC), immune-competent normal skin by IHC, IF RT-PCR on surgical discard. determined T cell polarization TSCC intracellular cytokine staining of crawl outs human explants. the effects IL-22, an inducer keratinocyte proliferation, proliferation vitro. are both associated with significantly higher numbers CD3+ CD8+...
No AccessJournal of UrologyClinical Urology: Original Articles1 Jul 1999BCL-2 AND P53 EXPRESSION IN CLINICALLY LOCALIZED PROSTATE CANCER PREDICTS RESPONSE TO EXTERNAL BEAM RADIOTHERAPYis corrected byERRATA DOUGLAS S. SCHERR, E. DARRACOTT VAUGHAN, JOHN WEI, MARILDA CHUNG, DIANE FELSEN, ROBERT ALLBRIGHT, and BEATRICE KNUDSEN SCHERRDOUGLAS SCHERR , VAUGHANE. VAUGHAN WEIJOHN WEI CHUNGMARILDA CHUNG FELSENDIANE FELSEN ALLBRIGHTROBERT ALLBRIGHT KNUDSENBEATRICE View All Author...
Progression of renal damage after relief unilateral ureteral obstruction (UUO) has been demonstrated, especially in neonatal rats. We evaluated function and 3-day UUO five groups adult rats: group 1, no treatment; 2, UUO; 3-5, followed by relief; 3, 7-day 4, 14-day 5, 28-day relief. Glomerular filtration rate (GFR), blood flow (RBF), tissue transforming growth factor-beta (TGF-beta), interstitial fibrosis fibroblast expression, tubular apoptosis, macrophage infiltration, expression nitric...
More than 30 years ago the decreased renal blood flow and glomerular filtration rate characteristic of unilateral ureteral obstruction (UUO) was described. In ensuing time, much has been learned about involvement nitric oxide (NO) transforming growth factor-beta (TGF-beta) in pathophysiology UUO.We measured dogs rats, assessed effect altering availability NO on these parameters. rats mice we used an antibody to TGF-beta, synthase gene deletion inducible therapy assess role TGF-beta...
Abstract Chloride intracellular channel 4 (CLIC4) is a mammalian homologue of EXC-4 whose mutation associated with cystic excretory canals in nematodes. Here we show that CLIC4-null mouse embryos exhibit impaired renal tubulogenesis. In both developing and developed kidneys, CLIC4 specifically enriched the proximal tubule epithelial cells, which important for luminal delivery, microvillus morphogenesis, endolysosomal biogenesis. Adult tubules display aberrant dilation. MDCK 3D cultures,...
Toradol is a new parenteral, nonsteroidal anti-inflammatory drug which efficacious in treating renal coli. In the present experiments, was administered to both control dogs and with unilateral ureteral obstruction. dogs, had no effect on RBF or GFR, despite inhibition of prostaglandin synthesis (measured as urinary release). contrast, fell acutely by 35% (p < 0.001) within 15 minutes administration setting obstruction; contralateral unaffected. Ipsilateral pressure also fell. Changes...
Unilateral ureteral obstruction (UUO) is characterized by decreases in renal function, increased interstitial fibrosis, tubular apoptosis, and cellular infiltration. It has been suggested that inhibition of apoptosis may protect against damage obstruction. We have recently developed a series peptides which are concentrated the inner mitochondrial membrane prevent cell death. These also active vivo, myocardial infraction, ischemic brain injury, amyotrophic lateral sclerosis models. therefore...
We studied the effect of transforming growth factor (TGF)-beta on immortalized human vocal fold fibroblasts.Normal fibroblasts were subjected to sequential lentiviral transduction with genes for telomerase (hTERT) and SV40 large T antigen in order produce an "immortalized" cell line normal phenotype. After confirmation fibroblast transfection, these cells, referred as HVOX, treated various concentrations exogenous TGF-beta1 assayed collagen secretion, migration, proliferation. In addition,...
Immune-suppressed organ transplant recipients (OTRs) can develop catastrophic squamous cell carcinoma (SCC), characterized by multiple primary tumors, extensive body surface area involvement, or metastases. There are currently no curative systemic therapies available. We previously showed that IL-22 enhances SCC proliferation. Herein, we examined links between cyclosporine (CSA), IL-22, and in patients, lines, mice with UV light-induced SCC. Eighteen of 114 OTRs developed SCC, which was...
No AccessJournal of UrologyINVESTIGATIVE UROLOGY1 Jan 2001MECHANISM OF HEALING FOLLOWING THE SNODGRASS REPAIR CLIFFORD B. BLEUSTEIN, MICHAEL P. ESPOSITO, ROBERT A. SOSLOW, DIANE FELSEN, and DIX POPPAS BLEUSTEINCLIFFORD BLEUSTEIN More articles by this author , ESPOSITOMICHAEL ESPOSITO SOSLOWROBERT SOSLOW FELSENDIANE FELSEN POPPASDIX View All Author Informationhttps://doi.org/10.1097/00005392-200101000-00078AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack...
In unilateral ureteral obstruction (UUO), the kidney is characterized by increased fibrosis and apoptosis. Both transforming growth factor-beta (TGF-beta) ANG II have been implicated, may mediate its effects through TGF-beta. Previous studies demonstrated amelioration of renal damage when either TGF-beta or has individually targeted. this study, we sought to determine whether combining 1D11 (monoclonal antibody TGF-beta) an ACE inhibitor, enalapril, would be more effective in UUO than...
Enlargement of the clitoris is often a prominent manifestation virilizing congenital adrenal hyperplasia and other disorders sexual development. Controversy persists regarding viability sensitivity following clitoroplasty. We present 51 consecutive cases nerve sparing ventral clitoroplasty performed by single surgeon.Nerve was in all patients. Postoperative evaluation for clitoral included gross examination capillary perfusion testing. Patients older than 5 years were evaluated sensory...
Mast cells are associated with inflammation and fibrosis. Whether they protect against or contribute to renal fibrosis is unclear. Based on our previous findings that mast can express secrete active renin, angiotensin (ANG II) profibrotic, we hypothesized play a critical role in tubulointerstitial We tested this hypothesis the 14-day unilateral ureteral obstruction (UUO) model rats cell-deficient (MCD) mice (WBB6F1-W/Wv) their congenic controls (CC). In UUO rat kidney, cell number increased...
Abstract T-cell landscape differences between cutaneous squamous cell carcinoma (cSCC) tumors in immune competent (SCC IC) and immunocompromised organ transplant recipients (TSCC OTR) are unclear. We developed an analytical method to define tumor infiltrating lymphocyte (TIL) phenotype cSCC from suppressed patients using single-cell TCR sequencing gene expression data. TSCC exhibits reduced proportions of cytotoxic naïve TILs similar numbers regulatory TILs. Fewer, more heterogeneous...