A5060186235- Dermatology and Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Monoclonal and Polyclonal Antibodies Research
- Urticaria and Related Conditions
- Immunodeficiency and Autoimmune Disorders
- T-cell and B-cell Immunology
- Cytokine Signaling Pathways and Interactions
- Mast cells and histamine
- Autoimmune Bullous Skin Diseases
- Colorectal and Anal Carcinomas
- Dermatologic Treatments and Research
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Hidradenitis Suppurativa and Treatments
- Antimicrobial Peptides and Activities
- Hair Growth and Disorders
- Skin and Cellular Biology Research
- melanin and skin pigmentation
- Kruppel-like factors research
- Connective Tissue Growth Factor Research
- Contact Dermatitis and Allergies
- Anorectal Disease Treatments and Outcomes
- Click Chemistry and Applications
Rockefeller University
2015-2024
Atopic dermatitis (AD) is the most common inflammatory skin disease, but treatment options for moderate-to-severe disease are limited. Ustekinumab an IL-12/IL-23p40 antagonist that suppresses Th1, Th17 and Th22 activation, commonly used psoriasis patients. We sought to assess efficacy safety of ustekinumab in patients with AD. In this phase II, double-blind, placebo-controlled study, 33 AD were randomly assigned either (n=16) or placebo (n=17), subsequent crossover at 16 weeks, last dose 32...
Abstract Psoriasis is a common immune‐mediated disease that affects 2%‐4% of individuals in North America and Europe. In the past decade, advances research have led to an improved understanding immune pathways involved pathogenesis psoriasis has spurred development targeted therapeutics. Recently, three autoantigens been described: cathelicidin ( LL 37), disintegrin metalloprotease domain containing thrombospondin type 1 motif‐like 5 ADAMTSL 5), lipid antigens generated by phospholipase A2...
Abstract Alopecia areata ( AA ) is a common inflammatory disease targeting the anagen‐stage hair follicle. Different cytokines have been implicated in profile, but their pathogenic role not yet fully determined. We studied biopsies of pretreatment lesional and non‐lesional NL scalp post‐treatment (intra‐lesional steroid injection) 6 patchy patients with using immunohistochemistry gene expression analysis. Immunohistochemistry showed increases CD 3 + , 8 T cells, 11c dendritic cells 1a...
Abstract Targeted inhibition of Rho-associated kinase (ROCK)2 downregulates the proinflammatory T cell response while increasing regulatory arm immune in animals models autoimmunity and Th17-skewing human culture vitro. In this study, we report that oral administration a selective ROCK2 inhibitor, KD025, reduces psoriasis area severity index scores by 50% from baseline 46% patients with vulgaris, it decreases epidermal thickness as well infiltration skin. We observed significant reductions...
A Disintegrin-like and Metalloprotease domain containing Thrombospondin type 1 motif-like 5 (ADAMTSL5) is a melanocyte-derived protein that has recently been implicated as an activating antigen for IL-17-producing T cells in psoriasis. There potential disconnect between the basal location of melanocytes epidermis fact T-cell infiltrates are seen mostly scattered with very large dermis. Thus, we hypothesized ADAMTSL5 may be expressed other aside from skin. To further investigate cutaneous...
Abstract Keloids are benign fibroproliferative tumors more frequently found among African Americans. Until now, keloid etiopathogenesis is not fully understood. To characterize keloids in Americans, we performed transcriptional profiling of biopsies from large chronic keloids, adjacent non‐lesional (NL) skin (n=3) and a newly formed lesion using Affymetrix HGU133 2.0 plus arrays. Quantitative RT‐PCR (qRT‐PCR) immunohistochemistry (IHC) staining were to confirm increased expression relevant...
Durable psoriasis improvement has been reported in a subset of patients after treatment withdrawal biologics blocking IL-23/Type 17 T-cell (T17) autoimmune axis. However, it is not well understood if systemic blockade the IL-23/T17 axis promotes immune tolerance skin. The purpose study was to find translational evidence that IL-17A regulatory transcriptome modification human skin cell subsets. We analyzed lesional 6 mm punch biopsy tissues before and using muti-genomics approach integrating...
Palmoplantar pustular psoriasis (PPPP) and non‒pustular palmoplantar (NPPP) are localized, debilitating forms of psoriasis. The inflammatory circuits involved in PPPP NPPP not well-understood. To compare the cellular immunological features that differentiate NPPP, skin biopsies were collected from a total 30 participants with PPPP, vulgaris (PV) 10 healthy participants. A subset consented to second biopsy after 3 additional weeks off medication. Histologic staining lesional nonlesional...
To the Editor: Many effective biologic treatments have been established for moderate-to-severe psoriasis, defined in most clinical trials as psoriasis with ≥10% body surface area and area-and-severity index (PASI) ≥12. Although patients mild-to-moderate constitute 82% of total population, are not permitted entry to newer agents.1Strober B. Ryan C. van de Kerkhof P. et al.Recategorization severity: Delphi consensus from International Psoriasis Council.J Am Acad Dermatol. 2020; 82:...
Abstract Targeted inhibition of Rho-associated kinase 2 (ROCK2) down-regulates pro-inflammatory T-cell response, while increasing the regulatory arm immune response in animals models autoimmunity and T helper 17 (Th17)-skewing human cell culture vitro. We conducted a Phase 2, open-label, dose-finding study to evaluate safety, tolerability, activity selective ROCK2 inhibitor, KD025, subjects with Psoriasis Vulgaris who failed first-line therapy (NCT02317627 at ClinicalTrials.gov). Here, we...