A5002464903- Cutaneous lymphoproliferative disorders research
- Lymphoma Diagnosis and Treatment
- Fungal Infections and Studies
- Nail Diseases and Treatments
- CAR-T cell therapy research
- Viral-associated cancers and disorders
- Toxin Mechanisms and Immunotoxins
- Nitric Oxide and Endothelin Effects
- Electron Spin Resonance Studies
- Retinal Diseases and Treatments
- T-cell and Retrovirus Studies
- Alzheimer's disease research and treatments
- Glaucoma and retinal disorders
- Metal complexes synthesis and properties
- Vascular Tumors and Angiosarcomas
- Cardiac electrophysiology and arrhythmias
- Advanced Glycation End Products research
- Skin Diseases and Diabetes
- Trace Elements in Health
- Monoclonal and Polyclonal Antibodies Research
- Colorectal and Anal Carcinomas
- Barrier Structure and Function Studies
- Sulfur Compounds in Biology
- TGF-β signaling in diseases
- Herpesvirus Infections and Treatments
The University of Tokyo
2018-2024
Rockefeller University
2024
International University of Health and Welfare
2018-2021
Asahikawa Medical College Hospital
1997-2010
Cornell University
2007
Hokkaido Institute of Public Health
2007
Case Western Reserve University
2007
The University of Texas at San Antonio
2007
Santen (Japan)
2002
Zinc, iron and copper are concentrated in senile plaques of Alzheimer disease. Copper catalyze the Fenton-Haber-Weiss reaction, which likely contributes to oxidative stress neuronal cells. In this study, we found that ascorbate oxidase activity intensity radicals measured using ESR spectroscopy, generated by free Cu(II), was decreased presence amyloid-beta (Abeta), major component plaques. Specifically, strongly inhibited (85% decrease) Abeta1-16 or Abeta1-42, whereas it only slightly...
Whereas atopic dermatitis (AD) is considered as a T helper 2 (Th2)-centered disease, IL-17–producing Th (Th17) cells are also activated in AD lesional skin. However, the relationship between Th17 responses and Th2 still to be elucidated. Although increased skin, expression function of IL-26, which produced by cells, unknown. In this report, we demonstrated that IL-26 mRNA levels were elevated skin compared with healthy controls IL-26-producing immunohistochemistry. Furthermore, promoted...
CD147, a transmembrane glycoprotein that belongs to the immunoglobulin superfamily, and cyclophilin A (CypA), one of binding partners are overexpressed in tumor cells associated with progression several malignancies, including both solid hematological malignancies. However, CD147 CypA involvement cutaneous T-cell lymphoma (CTCL) has not been reported. In this study, we examined expression function using clinical samples mycosis fungoides (MF) Sézary syndrome (SS) CTCL cell lines. were by...
Tumor cells in cutaneous T-cell lymphoma express limited numbers of chemokine receptors. We investigated the expression patterns CXCR3, CCR3, CCR4 and CCR10 mycosis fungoides, Sézary syndrome, lym-phomatoid papulosis anaplastic large cell 121 skin biopsy samples. CXCR3 was expressed 86% fungoides cases but no cases. CCR3 73% CD30+ lymphoproliferative disorders such as lymphomatoid lymphoma. Mycosis fungoides/Sézary syndrome patients with high or had a poorer survival prognosis than whose...
We investigated the inhibitory effects of bucillamine on formation laser-induced choroidal neovascularization (CNV) in a rat model.Bucillamine administration (approximately 150 mg/kg/day) was started 1 week before photocoagulation and continued to end study. Control groups received drinking water. Two weeks after photocoagulation, development evaluated using simultaneous fluorescein indocyanine green angiography, maximal thickness lesions measured histologically.The incidence CNV 99.5 +/-...
Reactions of 3-methyl-1-phenyl-2-pyrazoline-5-one (MCI-186) with hypochlorous acid and superoxide were analysed by spectrophotometry mass spectrometry. The results applied to the neutrophil system evaluate scavenging activity neutrophil-derived active oxygen species MCI-186. MCI-186 reacted rapidly (1 x 10(6) M(-1)s(-1)) form a chlorinated intermediate, followed slow conversion new spectrum. consumed 3 moles did not react superoxide. newly synthesized fluorescence probes,...
Abstract Fatty acid binding protein (FABP) is a family of transport proteins for fatty (FA). Epidermal FABP (E‐FABP) highly expressed by resident memory T cells (T RM ) in the skin. It supports uptake exogenous FA long‐term survival skin . Mycosis fungoides (MF) regarded as malignancy In this study, we investigated E‐FABP expression psoriasis vulgaris (PV), atopic dermatitis (AD), MF, and Sézary syndrome (SS). mRNA levels PV were much higher than those healthy controls. AD MF/SS lesional...
The clinical implications of DUSP22 rearrangement and the association between lymphoid enhancer-binding factor 1 (LEF1) expression pattern in CD30+ cutaneous T-cell lymphomas (CTCLs) are unknown.This study assessed incidence its immunohistochemical primary anaplastic large-cell lymphoma (pcALCL), lymphomatoid papulosis (LyP) mycosis fungoides with transformation (MF-LCT), focusing especially on prognosis LEF1 pattern. Prognostic factors pcALCL were also examined.We conducted a multicentre...
Progranulin (PGRN) is a multi-functional protein known to be involved in diverse biological processes, including tumourigenesis, anti-inflammation, and anti-infection. PGRN expression sera or tissues elevated variety of malignancies associated with poor prognosis. However, it remains determined whether Mycosis fungoides (MF). To investigate the roles MF. Serum levels were measured patients MF normal controls by enzyme-linked immunosorbent assay. skin was examined quantitative reverse...
Abstract In recent years, circulating cell‐free DNA (cfDNA) has received a great attention as biomarker for various cancers. Many reports have shown that serum cfDNA levels are elevated in cancer patients and their correlate with prognosis disease activity. The aim of this study was to measure cutaneous T‐cell lymphoma (CTCL) evaluate correlations hematological clinical findings. Serum CTCL were significantly higher than those healthy controls, gradually increased the progression stage....
Calf thymus DNA was treated with authentic HOCl, and hypohalous acid-generating systems. This caused a decrease in fluorescence of ethidium-DNA complexes when ethidium bromide subsequently added to the DNA. The continued up 30 min after adding HOCl. Loss proportional concentration HOCl complete 3-fold excess No significant observed chlorination carried out presence monochlorodimedone (MCD) equivalent that MCD is known react stoichiometrically completely inhibited by H2O2, ascorbate...
To investigate the effect of bucillamine for prevention increasing blood-retinal barrier (BRB) permeability in streptozotocin (STZ)-induced diabetic rats.The groups included control and STZ-induced rats treated with or without bucillamine. Six months after intervention, concentrations reduced oxidative glutathione (GSH GSSG) retina were measured biochemically. In addition, vitreous fluorescein, which leaks from vessels intravenous injection fluorescein sodium, was to evaluate BRB...
Visible light irradiation of 18 microM bilirubin ditaurate (BR-DT) at pH 7.0 for 30 min showed a 10% decrease in absorbance 445 nm. When the reaction was carried out presence trace amount uroporphyrin (UP), spectrum BR-DT disappeared without concomitant formation biliverdin. Photooxidation products were confirmed to be dipyrrole-containing compounds. Photo-bleaching accelerated by increasing concentration UP and inhibited, when replaced Cu2+UP. Formation 2,2,6,6-tetramethylpiperidine N-oxyl...
Reactions of thioureylene antithyroid drugs (1-methyl-2-mercaptoimidazole and carbimazole) with hypochlorous acid (HOCl) superoxide were followed optically products analyzed by mass spectrometry. 1-methyl-2-mercaptoimidazole (MMI) carbimazole reacted rapidly HOCl a rate constant 1 x 10(7) 7 10(6) M(-1)s(-1), respectively. The characteristic spectrum assigned to MMI disulfide appeared immediately after addition HOCl, slow conversion final spectrum. was dependent upon the ratio both uptake 3...