A5083030958- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Parathyroid Disorders and Treatments
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Cardiovascular Health and Disease Prevention
- Medical Imaging and Pathology Studies
- Psoriasis: Treatment and Pathogenesis
- Cancer Immunotherapy and Biomarkers
- Veterinary Medicine and Surgery
- Renal and related cancers
- Spaceflight effects on biology
- Immune Cell Function and Interaction
- Climate Change and Health Impacts
- Cancer Research and Treatments
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- CRISPR and Genetic Engineering
- T-cell and B-cell Immunology
- Heart Rate Variability and Autonomic Control
- Air Quality and Health Impacts
- Magnesium in Health and Disease
- Neuropeptides and Animal Physiology
- Single-cell and spatial transcriptomics
- Caveolin-1 and cellular processes
Rockefeller University
2023-2025
Second Affiliated Hospital of Nanchang University
2024
Nanchang University
2024
Jiangxi Provincial Cancer Hospital
2023
Hebei Medical University
2020-2023
Fourth Hospital of Hebei Medical University
2020-2023
China-Japan Friendship Hospital
2022
West China Medical Center of Sichuan University
2006
University of Cincinnati Medical Center
1994
T cells are present in all stages of tumor formation and play an important role the microenvironment. We aimed to explore expression profile cell marker genes, constructed a prognostic risk model based on these genes Lung adenocarcinoma (LUAD), investigated link between this immunotherapy response. obtained single-cell sequencing data LUAD from literature, screened out 6 tissue biopsy samples, including 32,108 patients with non-small lung cancer, identify LUAD. Combined TCGA database, T-cell...
Durable psoriasis improvement has been reported in a subset of patients after treatment withdrawal biologics blocking IL-23/Type 17 T-cell (T17) autoimmune axis. However, it is not well understood if systemic blockade the IL-23/T17 axis promotes immune tolerance skin. The purpose study was to find translational evidence that IL-17A regulatory transcriptome modification human skin cell subsets. We analyzed lesional 6 mm punch biopsy tissues before and using muti-genomics approach integrating...
To identify serum microRNAs (miRNAs) as potential non-invasive biomarkers for patients with chronic kidney disease (CKD).We collected samples from healthy controls, CKD stage 1 (CKD1), and 5 (CKD5) primary glomerulonephritis (GN), screened differentially expressed miRNAs (DEMs) using next-generation sequencing (NGS), confirmed the data quantitative reverse transcriptase polymerase chain reaction (qRT-PCR).We identified 20 42 DEMs in CKD1 CKD5 compared respectively, 70 patients. The qRT-PCR...
Vascular calcification, such as atherosclerosis, is a serious complication of chronic kidney disease that characterized by tunica media and has gained increasing attention from researchers. The commonly observed association between vascular calcification osteoporosis suggests link bone disorders. As microRNAs (miRNAs) have wide range gene regulation functions, cell proliferation, apoptosis, stress transdifferentiation, the current study aimed to determine whether miRNAs play vital role in...
Previous studies have shown that the apoptosis of vascular smooth muscle cells (VSMCs) underlies mechanism pathological calcification in patients with chronic kidney disease (CKD). SET domain-containing protein 8 (SET8) is an efficient modulates hepatocellular carcinoma cells, esophageal squamous and neuronal by regulating processes, such as cell cycle progression transcription regulation. However, whether SET8 involved high phosphorus-induced mediating remains unclear. Here, we report...
Abstract Objective In order to find new strategies for the prevention of vascular calcification in uremic individuals especially treated by dialysis and develop novel therapeutic targets calcification, we explore role KCa3.1 alkalinization‐induced VSMCs vitro. Method Rat model was established beta‐glycerophosphate (β‐GP, 10 mM) induction. The pH Dulbecco's modified Eagle's medium (DMEM) adjusted every 24 h with mM HCl or NaHCO 3 . mineralization measured Alizarin Red staining...
No research report has been conducted to investigate the impact of oxidation balance score (OBS) on estimated pulse wave velocity(ePWV).We aimed examine association between OBS and ePWV. We evaluated data for 13,073 patients from National Health Nutrition Examination Survey (NHANES). The exposure variable was OBS. outcome variables combination ePWV arterial stiffness. observed a significant negative correlation (Per 1SD increase) in gradually adjusted models. Based aforementioned results,...
Abstract The adaptation of the endogenous rhythm an organism to external cycles may influence development physiological processes in animals. Light not only synchronizes circadian system, but also exerts profound direct effects: immediate reduction melatonin release at night-time and inhibition locomotor activity nocturnal rodents after a light pulse are well-known examples, yet little is known about effects different light/dark (LD) on level corticosterone, growth hormone rate. Mice were...