A5074062786- Phagocytosis and Immune Regulation
- RNA regulation and disease
- Erythrocyte Function and Pathophysiology
- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Pluripotent Stem Cells Research
- HIV Research and Treatment
- Psoriasis: Treatment and Pathogenesis
- Skin Protection and Aging
- melanin and skin pigmentation
- Immunodeficiency and Autoimmune Disorders
- Cytomegalovirus and herpesvirus research
- interferon and immune responses
- COVID-19 Clinical Research Studies
- Viral Infections and Immunology Research
- Tryptophan and brain disorders
- Immune Cell Function and Interaction
- Blood disorders and treatments
Columbia University
2024
Yale University
2017-2023
Icahn School of Medicine at Mount Sinai
2023
Rockefeller University
2013
Mount Holyoke College
2012-2013
Knockout (KO) mouse models play critical roles in elucidating biological processes behind disease-associated or disease-resistant traits. As a presumed consequence of gene KO, mice display certain phenotypes. Based on insight into the molecular role said process, it is inferred that particular process causally underlies trait. This approach has been crucial towards understanding basis pathological and/or advantageous traits associated with Mertk KO mice. suffer from severe, early-onset...
Severe, early-onset photoreceptor (PR) degeneration associated with
Summary Type I interferons (IFN-I) are cytokines with potent antiviral and inflammatory capacities. IFN-I signaling drives the expression of hundreds stimulated genes (ISGs), whose aggregate function results in control viral infection. A few these ISGs tasked negatively regulating response to prevent overt inflammation. ISG15 is a negative regulator absence leads persistent, low-grade elevation ISG concurrent, self-resolving mild autoinflammation. The limited breadth persistence expressed...
Abstract Murine acquired immunodeficiency syndrome (MAIDS), induced by exposure to murine leukemia virus (MuLV), serves as an animal model study human AIDS. While infection with the LP-BM5 isolate of MuLV leads progressive immune compromise in MAIDS-susceptible C57BL/6 mice, resistant BALB/c mice launch directed and controlled responses eradicate develop protective immunity. Since modulation immunosuppressant molecule activities after viral may shape disease progression, we aimed...
ABSTRACT Knockout (KO) mouse models play critical roles in elucidating biological processes behind disease-associated or disease-resistant traits. As a consequence of gene KO, mice display certain phenotypes. Based on insight into the molecular role said process, it is inferred that particular process causally underlies trait. This approach has been crucial towards understanding basis pathological and/or advantageous traits associated with Mertk KO. MERTK receptor tyrosine kinase...
Abstract Murine acquired immunodeficiency syndrome (MAIDS), caused by the murine leukemia virus (MuLV), serves as an animal model to study human AIDS. Infection with LP-BM5 isolate of MuLV leads progressive in MAIDS-susceptible C57BL/6 mice, while resistant BALB/c mice are able mount a direct and controlled immune response eradicate virus. Experiments measuring protein expression two natural immunosuppressive molecules, indoleamine 2, 3-dioxygenease (IDO) interleukin-10 (IL-10), showed...
Abstract Severe, early-onset photoreceptor (PR) degeneration associated with MERTK mutations is thought to result from failed phagocytosis by retinal pigment epithelium (RPE). Notwithstanding, the severity and onset of PR in mouse models Mertk ablation determined hypomorphic expression or loss paralog Tyro3 . Here we find that reduced expression/loss led RPE inflammation even before eye-opening. Incipient cascaded involve microglia activation monocyte infiltration. Inhibition JAK1/2...