A5023260904- Phagocytosis and Immune Regulation
- Autophagy in Disease and Therapy
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Erythrocyte Function and Pathophysiology
- RNA modifications and cancer
- Immune cells in cancer
- Neuroscience and Neuropharmacology Research
- Hippo pathway signaling and YAP/TAZ
- COVID-19 Clinical Research Studies
- Pain Mechanisms and Treatments
- Pancreatitis Pathology and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Mitochondrial Function and Pathology
- Immunotherapy and Immune Responses
- Neurogenesis and neuroplasticity mechanisms
- RNA Research and Splicing
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Pancreatic function and diabetes
- Advanced biosensing and bioanalysis techniques
- Ion channel regulation and function
- Genomics and Chromatin Dynamics
- Biomarkers in Disease Mechanisms
- Cell death mechanisms and regulation
Yale University
2016-2025
Ramakrishna Mission Vidyamandira
2024
Western University
2024
University of Calcutta
2022-2024
Jadavpur University
2024
University of Kalyani
2017-2023
Academy of Scientific and Innovative Research
2013-2023
Institute of Genomics and Integrative Biology
2012-2023
IE University
2023
University School
2023
Local macrophage clean-up Infection, especially by helminths or bacteria, can cause tissue damage (see the Perspective Bouchery and Harris). Minutti et al. studied mouse models of helminth infection fibrosis. They expressed surfactant protein A (a member complement component C1q family) in lung, which enhanced interleukin-4 (IL-4)-mediated proliferation activation alveolar macrophages. This accelerated clearance reduced lung injury. In peritoneum, boosted for liver repair after bacterial...
Cell death is prevalent throughout life; however, the coordinated interactions and roles of phagocytes during corpse removal in live brain are poorly understood. We developed photochemical viral methodologies to induce single cells combined this with intravital optical imaging. This approach allowed us track multicellular phagocytic precise spatiotemporal resolution. Astrocytes microglia engaged dying neurons an orchestrated synchronized fashion. Each glial cell played specialized roles:...
Macrophages are functionally heterogeneous cells essential for apoptotic cell clearance. Apoptotic defined by homogeneous characteristics, ignoring their original lineage identity. We found that in an interleukin-4 (IL-4)-enriched environment, the sensing of neutrophils macrophages triggered tissue remodeling signature. Engulfment hepatocytes promoted a tolerogenic phenotype, whereas phagocytosis T had little effect on IL-4-induced gene expression. In mouse model parasite-induced pathology,...
Macrophages are a source of both proinflammatory and restorative functions in damaged tissue through complex dynamic phenotypic changes. Here, we sought to determine whether monocyte-derived macrophages (MDMs) contribute recovery after acute sterile brain injury. By profiling the transcriptional dynamics MDMs murine experimental intracerebral hemorrhage (ICH), found robust changes infiltrating over time demonstrated that essential for optimal hematoma clearance neurological recovery. Next,...
The receptor tyrosine kinases Axl and Mer, belonging to the Tyro3, Mer (TAM) family, are expressed in a number of tumor cells have well-characterized oncogenic roles. therapeutic targeting these is considered an anticancer strategy, various inhibitors currently under development. At same time, dendritic macrophages essential function limiting inflammation. Inflammation enabling characteristic multiple cancer hallmarks. These contrasting anti-inflammatory functions posit potential paradox...
The advent of high-throughput genome scale technologies has enabled us to unravel a large amount the previously unknown transcriptionally active regions genome. Recent genome-wide studies have provided annotations repertoire various classes noncoding transcripts. Long RNAs (lncRNAs) form major proportion these novel annotated transcripts, and presently known be involved in number functionally distinct biological processes. Over 18 000 transcripts are as lncRNA, encompass including intergenic...
A major fraction of the transcriptome higher organisms comprised an extensive repertoire long non-coding RNA (lncRNA) which express in a cell type and development stage-specific manner. While lncRNAs are proven component epigenetic gene expression modulation, regulation lncRNA itself remains poorly understood. Here we have analysed pan-genomic DNA methylation histone modification marks (H3K4me3, H3K9me3, H3K27me3 H3K36me3) associated with transcription start site (TSS) four different types...
Sensitization of the pain pathway is believed to promote clinical disorders. We hypothesized that persistence a sensitized state in spinal dorsal horn might depend on activity protein kinase M ζ (PKMζ), an essential mechanism late long-term potentiation (LTP). To test this hypothesis, we used intraplantar injections interleukin-6 (IL-6) mice elicit transient allodynic endured ∼3 d. After resolution IL-6-induced allodynia, subsequent injection prostaglandin E 2 (PGE ) or intrathecal...
Abstract Billions of cells are eliminated daily from our bodies 1–4 . Although macrophages and dendritic dedicated to migrating engulfing dying debris, many epithelial mesenchymal tissue can digest nearby apoptotic corpses How these non-motile, non-professional phagocytes sense eliminate while maintaining their normal functions is unclear. Here we explore the mechanisms that underlie multifunctionality by exploiting cyclical bouts regeneration degeneration during hair cycling. We show...
Using pharmacological and genetic methods, we show that inhibition of mTORC1 induces sensory neuron hyperexcitability pain via feedback activation ERK. Mammalian target rapamycin complex 1 (mTORC1) inhibitors are extensively used as immunosuppressants to prevent transplant rejection in treatment certain cancers. In patients, chronic with or its analogues (rapalogues) has been reported lead hypersensitivity conditions an unknown mechanism. Here, activates the extracellular signal-regulated...
Background Chronic pain is an important medical problem affecting hundreds of millions people worldwide. Mechanisms underlying the maintenance chronic states are poorly understood but elucidation such mechanisms have potential to reveal novel therapeutics capable reversing a state. We recently shown that state dependent on atypical PKC, PKMζ, involved in controlling PKMζ completely unknown. Here we tested hypothesis brain derived neurotrophic factor (BDNF) regulates and possibly other aPKCs,...
Transcriptional regulation of genes by cyclic AMP response element binding protein (CREB) is essential for the maintenance long-term memory. Moreover, retrograde axonal trafficking CREB in to nerve growth factor (NGF) critical survival developing primary sensory neurons. We have previously demonstrated that hindpaw injection interleukin-6 (IL-6) induces mechanical hypersensitivity and hyperalgesic priming prevented local synthesis inhibitors. However, proteins are locally synthesized might...