A5073298216- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- interferon and immune responses
- Trypanosoma species research and implications
- Cytomegalovirus and herpesvirus research
- CAR-T cell therapy research
- Viral Infections and Outbreaks Research
- Herpesvirus Infections and Treatments
- Research on Leishmaniasis Studies
- Immune responses and vaccinations
- Viral gastroenteritis research and epidemiology
- Viral Infections and Vectors
- Cytokine Signaling Pathways and Interactions
- Immune cells in cancer
- Galectins and Cancer Biology
- Diabetes and associated disorders
- Single-cell and spatial transcriptomics
- SARS-CoV-2 and COVID-19 Research
- Proteoglycans and glycosaminoglycans research
- Glycosylation and Glycoproteins Research
- Animal Virus Infections Studies
- Hepatitis B Virus Studies
- Reproductive System and Pregnancy
University of California, San Diego
2016-2025
La Jolla Alcohol Research
2023
Division of Chemistry
2019
Universidad Autónoma de Ciudad Juárez
2018
Imperial College London
2014
Scripps Research Institute
2004-2008
Universidad Nacional de Córdoba
1999-2007
Immune Regulation (United Kingdom)
2003
University of Birmingham
2003
Multiple inhibitory molecules create a profoundly immunuosuppressive environment during chronic viral infections in humans and mice. Therefore, eliciting effective immunity this context represents challenge. Here, we report that murine infection, interleukin-6 (IL-6) was produced by irradiation-resistant cells biphasic manner, with late IL-6 being absolutely essential for control. The underlying mechanism involved signaling on virus-specific CD4 T caused up-regulation of the transcription...
Despite the importance of co-receptor PD-1 in T cell immunity, upstream signaling pathway that regulates expression has not been defined. Glycogen synthase kinase 3 (GSK-3, isoforms α and β) is a serine-threonine implicated cellular processes. Here, we identified GSK-3 as key regulated CD8+ cells. siRNA downregulation, or inhibition by small molecules, blocked expression, resulting increased cytotoxic lymphocyte (CTL) function. Mechanistically, inactivation Tbx21 transcription, promoting...
Abstract Type I Interferons (IFN-I) are central to host protection against viral infections, with plasmacytoid dendritic cells (pDC) being the most significant source, yet pDCs lose their IFN-I production capacity following an initial burst of IFN-I, resulting in susceptibility secondary infections. The underlying mechanisms these dynamics not well understood. Here we find that infection reduces engage both oxidative and glycolytic metabolism. Mechanistically, identify lactate dehydrogenase...
The prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) is a formidable battle horse for the study of viral immunology, as well persistence and associated diseases. Investigations with LCMV have uncovered basic mechanisms by which viruses avoid elimination host adaptive immune response. In this we show that also disables innate defense interfering beta interferon (IFN-beta) production in response to different stimuli, including infection Sendai liposome-mediated DNA transfection....
Abstract Galectin-1 (GAL-1), a highly conserved β-galactoside-binding protein, has shown immunomodulatory properties. In this study, we investigated the regulation of GAL-1 expression within B-cell compartment usingTrypanosoma cruzi infection as natural model in vivo activation. was found to be expressed on activated B cells from T. cruzi-infected mice, mainly localized at cytosolic compartment. Expression protein modulated according activation state cells, revealing significant increase...
Abstract The role of transcription factors in B cell survival and differentiation has been delineated during the last years. However, little is known about intermediate signals intracellular pathways that control these events. In this study, we provide evidence both vitro vivo, showing galectin-3 (Gal-3), a β-galactoside-binding protein, critical mediator survival. Although Gal-3 not expressed resting cells from normal mice, its expression markedly induced after activation with stimuli such...
Intestinal barrier leakage constitutes a potential therapeutic target for many inflammatory diseases and represents disease progression marker during chronic viral infections. However, the causes of altered gut remain mostly unknown. Using murine infection with lymphocytic choriomeningitis virus, we demonstrate that, in contrast to an acute strain, persistent isolate leads long-term replication hematopoietic mesenchymal cells, but not epithelial cells (IECs), intestine. Viral persistence...
ABSTRACT Galectin-1 is a β-galactoside-binding protein with potent anti-inflammatory and immunoregulatory effects. However, its expression function have not been assessed in the context of an infectious disease. The present study documents, for first time, regulated galectin-1 process influence modulation macrophage microbicidal activity survival. A biphasic parasite replication cell viability was observed when macrophages isolated from Trypanosoma cruzi -infected mice were exposed to...
Several arenaviruses cause hemorrhagic fever (HF) diseases that are associated with high morbidity and mortality in humans. Accordingly, HF have been listed as top-priority emerging for which countermeasures urgently needed. Because arenavirus nucleoprotein (NP) plays critical roles both virus multiplication immune-evasion, we used an unbiased proteomic approach to identify NP-interacting proteins human cells. DDX3, a DEAD-box ATP-dependent-RNA-helicase, interacted NP NP-transfected...