A5059394217- melanin and skin pigmentation
- Biochemical Analysis and Sensing Techniques
- Genetic and rare skin diseases.
- Skin Protection and Aging
- RNA regulation and disease
- Dermatology and Skin Diseases
- Cutaneous Melanoma Detection and Management
- Acne and Rosacea Treatments and Effects
- Retinoids in leukemia and cellular processes
- Autoimmune Bullous Skin Diseases
- Vascular Malformations and Hemangiomas
- Tumors and Oncological Cases
- Cancer and Skin Lesions
- Olfactory and Sensory Function Studies
- Medicine and Dermatology Studies History
- Retinal Development and Disorders
- Herpesvirus Infections and Treatments
- Hair Growth and Disorders
- Psoriasis: Treatment and Pathogenesis
- Endoplasmic Reticulum Stress and Disease
- Dermatological and Skeletal Disorders
- Cutaneous lymphoproliferative disorders research
- RNA Interference and Gene Delivery
- Skin and Cellular Biology Research
- Cancer therapeutics and mechanisms
New York University
2016-2025
NYU Langone Health
1996-2023
Pfizer (United Kingdom)
2022
Sanofi (Mexico)
2022
Regeneron (United States)
2022
Estée Lauder (United States)
2022
Bristol-Myers Squibb (Germany)
2022
Janssen (Belgium)
2022
Sanofi (France)
2022
LEO Foundation
2022
INTRODUCTION: Acne vulgaris is one of the most common skin conditions in children and adolescents. The presentation, differential diagnosis, association acne with systemic pathology differs by age presentation. Current acknowledged guidelines for diagnosis management pediatric are lacking, there variations across spectrum primary specialty care. American Rosacea Society convened a panel dermatologists, pediatricians, dermatologists expertise to develop recommendations evidence-based...
We evaluated the frequency of an association cutaneous cervicofacial hemangiomas in a "beard" distribution (including preauricular areas, chin, anterior neck, and lower lip) with symptomatic upper airway or subglottic areas. Of 529 patients seen, 187 were pediatric head neck. Sixteen (8.5%) had lesions beard distribution, score 4 greater. Ten these 16 (63%) some degree involvement, four 10 (40%) required tracheotomy. The presence should alert evaluating physician to potential involvement.
<h3>Background</h3> The pathogenesis of infantile hemangiomas is not yet understood. Growth factors and hormonal mechanical influences have been thought to affect the focal abnormal growth endothelial cells in these lesions. However, may represent secondary responses an underlying primary molecular event leading development hemangiomas. <h3>Observations</h3> We report rare familial occurrence and/or vascular malformations 6 kindreds, suggesting autosomal dominant inheritance. In families,...
Background Reports of successful treatment atopic dermatitis (AD) with mycophenolate mofetil (MMF) have thus far been limited to adults. Considering that the condition typically develops during childhood and is most active this period, MMF would represent a valuable addition therapeutic armamentarium for paediatric AD. Objectives To evaluate safety efficacy in severe Methods A retrospective analysis was performed all children treated as systemic monotherapy severe, recalcitrant AD between...
Most metastatic melanoma patients fail to respond available therapy, underscoring the need for novel approaches identify new effective treatments. In this study, we screened 2,000 compounds from Spectrum Library at a concentration of 1 micromol/L using two chemoresistant cell lines (M-14 and SK-Mel-19) spontaneously immortalized, nontumorigenic melanocyte line (melan-a). We identified 10 that inhibited growth cells yet were largely nontoxic melanocytes. Strikingly, 4 (mebendazole,...
<ns4:p>Vitiligo, an acquired depigmentation disorder, manifests as white macules on the skin and can cause significant psychological stress stigmatization. Recent advances have shed light key components that drive disease onset progression well therapeutic approaches. Vitiligo be triggered by to melanin pigment-producing cells of skin, melanocytes. The triggers, which range from sunburn mechanical trauma chemical exposures, ultimately autoimmune response targets melanocytes, driving...
<h3>Importance</h3> To date, no study has characterized the mucocutaneous features seen in hospitalized children with multisystem inflammatory syndrome (MIS-C) or temporal association of these findings onset systemic symptoms. <h3>Objective</h3> describe MIS-C during height coronavirus disease 2019 (COVID-19) pandemic New York City 2020. <h3>Design, Setting, and Participants</h3> A retrospective case series was conducted 35 admitted to 2 hospitals between April 1 July 14, 2020, who met...
Infantile hemangiomas are the most common tumor of infancy, occurring with an incidence up to 10% all births. They benign but highly proliferative lesions involving aberrant localized growth capillary endothelium. Although occur sporadically and as single lesions, or in conjunction pleiotropic genetic syndromes, we have previously identified six kindreds where appear segregate autosomal dominant trait high penetrance. Four such families contain affected individuals three more generations. In...
The pink-eyed dilution (p) locus in the mouse is critical to melanogenesis; mutations homologous humans, P, are a cause of type II oculocutaneous albinism. Although cDNA encoded by p gene has recently been identified, nothing known about protein product this gene. To characterize gene, we performed immunoblot analysis extracts melanocytes cultured from wild-type mice with an antiserum rabbits immunized peptide corresponding amino acids 285-298 predicted murine This recognized 110-kDa...
The silver mutation in mice causes progressive graying of hair due to the loss functional follicular melanocytes. Recently locus gene (called Pmel 17) has been cloned; its encoded product shares homology with a chick melanosomal matrix protein and bovine retinal pigment epithelial protein. Although sequence correlation expression production have reported, function melanogenesis is still unknown. In an effort characterize that function, we synthesized predicted carboxyl-terminal peptide mouse...
The processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis, was investigated melan-p1 melanocytes, are null at p locus. Endoglycosidase H digestion showed that a significant fraction tyrosinase retained endoplasmic reticulum. This retention could be rescued either by transfection cells with an epitope-tagged wild-typep transcript or treatment bafilomycin A1 ammonium chloride. We found reticulum contains amount protein, thus supporting role for within this...