A5000785399- Cytokine Signaling Pathways and Interactions
- Cancer and Skin Lesions
- melanin and skin pigmentation
- Dermatology and Skin Diseases
- Biochemical Analysis and Sensing Techniques
- Hedgehog Signaling Pathway Studies
- RNA regulation and disease
- Cutaneous lymphoproliferative disorders research
- Allergic Rhinitis and Sensitization
- Urticaria and Related Conditions
- Genetic and rare skin diseases.
- Immunotherapy and Immune Responses
- Autoimmune Bullous Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Viral Infectious Diseases and Gene Expression in Insects
- Sarcoma Diagnosis and Treatment
- Drug-Induced Adverse Reactions
- Fungal Plant Pathogen Control
- Mast cells and histamine
- Inflammatory Myopathies and Dermatomyositis
- Contact Dermatitis and Allergies
- Nonmelanoma Skin Cancer Studies
- T-cell and Retrovirus Studies
- Cutaneous Melanoma Detection and Management
- Cancer-related Molecular Pathways
National Kyushu Medical Center
2014-2025
Fujimoto Pharmaceutical Corporation (Japan)
2011-2024
Clinical Research Institute
2015
National Hospital Organization
2010-2014
Kyushu University
2002-2012
Huazhong University of Science and Technology
2007-2008
Union Hospital
2008
Advanced Dermatology
2007
Kyushu University Hospital
2005-2006
The University of Tokyo
2005
The significance of melanotropic hormones as physiologic regulators cutaneous pigmentation in humans is still controversial. Until recently, no direct effect for melanotropins could be demonstrated on human melanocytes. Here we present conclusive evidence that alpha-melanotropin (alpha-melanocyte-stimulating hormone, alpha-MSH) and the related hormone corticotropin (adrenocorticotropic ACTH) stimulate proliferation melanogenesis melanocytes maintained culture a growth medium lacking any AMP...
Since the characterization of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) as a major melanogenic intermediate, fate this compound and mechanisms its incorporation into melanin polymer have become issues in study melanogenesis. DHICA is stable dihydroxyindole with low rate spontaneous oxidation, suggesting that enzymatic mechanism(s) might contribute to evolution. The most obvious candidates are melanosomal tyrosinases. We recently shown mouse melanosomes contain two electrophoretically...
Basic fibroblast growth factor (bFGF) has been shown to promote wound healing. The present trial evaluated the clinical efficacy of bFGF for diabetic ulcer, a type refractory skin and dose-response relationship. This was designed as randomized, double-blind, dose-ranging, placebo-controlled trial. A total 150 patients with non-ischaemic ulcers measuring 900 mm2 or less were randomized into placebo group (n = 51), 0.001% 49) 0.01% 50), 148 these received treatment 8 weeks less. evaluation...
Journal Article Clinical dose and adverse effects of topical steroids in daily management atopic dermatitis Get access M. Furue, Furue Department Dermatology Masutaka MD E‐mail: furue@dermatol.med.kyushu‐u.ac.jp Search for other works by this author on: Oxford Academic Google Scholar H. Terao, Terao W. Rikihisa, Rikihisa K. Urabe, Urabe N. Kinukawa, Kinukawa Medical Information Science, Graduate School Sciences, Kyushu University, Maidashi 3‐1‐1, Higashi‐ku, Fukuoka 812‐8582, Japan Y. Nose,...
The silver mutation in mice causes progressive graying of hair due to the loss functional follicular melanocytes. Recently locus gene (called Pmel 17) has been cloned; its encoded product shares homology with a chick melanosomal matrix protein and bovine retinal pigment epithelial protein. Although sequence correlation expression production have reported, function melanogenesis is still unknown. In an effort characterize that function, we synthesized predicted carboxyl-terminal peptide mouse...
Tyrosinase (EC 1.14.18.1) is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; hydroxylation of tyrosine to L-3,4-dihydroxyphenylalanine (dopa) and subsequent oxidation dopa dopaquinone. It has been proposed tyrosinase also able oxidize 5,6-dihydroxyindole (DHI), later product melanogenic pathway, indole-5,6-quinone. enzymatic activity deficient patients with classic type I oculocutaneous albinism (OCA), more than 50 distinct...
The effect of melanocyte-stimulating hormone (MSH) on the differentiation mammalian melanocytes has been widely studied since early 1950s. There have many reports about stimulatory MSH melanin production and specifically activity tyrosinase, critical enzyme in melanogenic pathway. However, few variable results obtained concerning this regulation DOPAchrome tautomerase (TRP2), another which functions later pathway, or other activities, such as TRP1. In study, we show that MSH-induced...
Background Adult T-cell leukaemia/lymphoma (ATLL) is a human malignancy associated with leukaemia virus type I (HTLV-I). ATLL frequently involves the skin. Objectives To correlate clinicopathological features and prognosis in patients cutaneous lesions. Methods We examined HTLV-I proviral state of lesions 80 serum anti-ATL antibody, to clarify correlation between macroscopic/histopathological findings prognosis. Southern blot analysis was performed all cases detect monoclonal DNA...
Abstract Background Prurigo nodularis (PN), a chronic inflammatory skin condition, adversely affects the quality of life affected individuals. Current treatment options for PN in Japan are limited. Objectives To evaluate optimal dose, efficacy and safety long-term with nemolizumab patients Japan. Methods In 16-week double-blind phase II/III study, aged ≥ 13 years were randomly assigned (1 : 1 1) to 30-mg, 60-mg or placebo groups, concomitant topical corticosteroids, every 4 weeks. The...
Background Although there have been several reports on the prevalence of atopic dermatitis (AD) in Japanese schoolchildren based questionnaires, has no nation-wide study frequency this condition diagnosed by dermatologists regular health check-ups schoolchildren. Objectives The objective work was to evaluate precisely AD elementary Japan dermatologists. Methods In 2001/2, schoolchildren: first graders (age 6–7 years) and sixth 11–12 were examined eight prefectures (Hokkaido, Iwate, Tokyo,...
Sporotrichosis is caused by a thermo-dependent dimorphic fungus, Sporothrix schenckii. The major clinical manifestations occur in the skin; however, cases of visceral have also been increasingly reported with some being observed immune compromised patients. Different virulence individual S. schenckii strain as well status host could contribute to form such different manifestations. Thus, purpose study was investigate whether be factor for difference. We investigated interactions between...
Abstract Reducing casein kinase 1α (CK1α) expression inhibits the growth of multiple cancer cell lines, making it a potential therapeutic target for cancer. Herein, we evaluated anti-tumor activity FPFT-2216—a novel low molecular weight compound—in lymphoid tumors and elucidated its mechanism action. Additionally, determined whether targeting CK1α with FPFT-2216 is useful treating hematopoietic malignancies. strongly degraded IKAROS family zinc finger 1/3 (IKZF1/3) via proteasomal...
Mutations in the human homologue of Drosophila patched (PTCH) have been identified patients with nevoid basal cell carcinoma syndrome (NBCCS; also called Gorlin syndrome) as well sporadic carcinomas and medulloblastomas. However, using PCR-SSCP analysis, mutations PTCH found only a fraction (about one third to half) NBCCS patients. In this study, we determined whole genomic organizations PTCHgene developed new set more accurate primers for analysis PTCH. Using these primers, examined 8...