A5088000199- Food Allergy and Anaphylaxis Research
- Immunodeficiency and Autoimmune Disorders
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Eosinophilic Esophagitis
- Respiratory viral infections research
- Pediatric health and respiratory diseases
- Celiac Disease Research and Management
- Dermatology and Skin Diseases
- Viral gastroenteritis research and epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- Parvovirus B19 Infection Studies
- Cystic Fibrosis Research Advances
- Pneumonia and Respiratory Infections
- Immune Cell Function and Interaction
- Transgenic Plants and Applications
- Blood disorders and treatments
- Drug-Induced Adverse Reactions
- Respiratory and Cough-Related Research
- Bacterial Infections and Vaccines
- Down syndrome and intellectual disability research
- Infant Health and Development
- Nasal Surgery and Airway Studies
- Coronary Artery Anomalies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Brigham and Women's Hospital
2022-2025
Immune Tolerance Network
2022-2025
Harvard University
2022-2024
Benaroya Research Institute
2022-2024
Brigham and Women's Faulkner Hospital
2024
Duke University
2020-2023
Duke University Health System
2020
Duke Medical Center
2018-2020
Children's Hospital of Pittsburgh
2016
BackgroundA randomized trial demonstrated consumption of peanut from infancy to age 5 years prevented the development allergy. An extension that effect persisted after 1 year avoidance. This follow-up examined durability tolerance at 144 months ad libitum consumption.MethodsParticipants a were assessed for allergy following an extended period eating or avoiding peanuts as desired. The primary end point was rate months.ResultsWe enrolled 508 original 640 participants (79.4%); 497 had complete...
ABSTRACT Background Intestinal barrier dysfunction may lead to a break in tolerance and development of food allergy (FA). There is contradictory evidence on whether intestinal permeability (IP) altered IgE‐mediated FA. Thus, we sought determine IP differed between children with eczema who did (FA group) or not (atopic controls, ACs) develop FA peanut sensitization, allergy, early introduction impacted using serum biomarkers zonulin, soluble CD14, Fatty Acid Binding Protein among randomly...
Immune tolerance induction (ITI) with a short-course of rituximab, methotrexate, and/or IVIG in the enzyme replacement therapy (ERT)-naïve setting has prolonged survival and improved clinical outcomes patients infantile Pompe disease (IPD) lacking endogenous acid-alpha glucosidase (GAA), known as cross-reactive immunologic material (CRIM)-negative. In context cancer therapy, rituximab administration results sustained B-cell depletion 83% for up to 26-39 weeks reconstitution beginning at...
Factors influencing vaccine immune priming in the first year of life involve both innate and adaptive immunity but there are gaps understanding how these factors sustain antibody levels healthy infants. The hypothesis was that bioprofiles associated with B cell survival best predict sustained IgG at one year.Longitudinal study plasma 82 term, infants, who received standard recommended immunizations United States, changes 15 biomarker concentrations subsets germinal center development...
Abstract Individuals with Down syndrome (DS) have been particularly impacted by respiratory conditions, such as pneumonia. However, the description of co‐occurring recurrent infections, response to pneumococcal immunization, and association these was previously unknown. We screened individuals DS using an 11‐item screener prospectively collected titers laboratory results. found that did not successfully predict which who would inadequate titers. Thirty four 55 (62%) had abnormal...