A5100378158- Inflammatory Bowel Disease
- Genetic and phenotypic traits in livestock
- Cancer-related molecular mechanisms research
- Microscopic Colitis
- Eosinophilic Esophagitis
- Pancreatic and Hepatic Oncology Research
- COVID-19 and healthcare impacts
- COVID-19 Clinical Research Studies
- Helicobacter pylori-related gastroenterology studies
- Molecular Biology Techniques and Applications
- Gastrointestinal disorders and treatments
- Genetic Mapping and Diversity in Plants and Animals
- Immune Cell Function and Interaction
- Mycobacterium research and diagnosis
- Hepatitis B Virus Studies
- Cancer Genomics and Diagnostics
- Vaccine Coverage and Hesitancy
- Autoimmune and Inflammatory Disorders
- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Pregnancy and Medication Impact
- Cardiovascular Health and Risk Factors
- Anesthesia and Pain Management
- Viral gastroenteritis research and epidemiology
- Gastrointestinal motility and disorders
Second Affiliated Hospital of Zhejiang University
2016-2025
Zhejiang University
2015-2025
Binzhou University
2024-2025
Binzhou Medical University
2023-2025
Second Xiangya Hospital of Central South University
2018-2024
Central South University
2005-2024
Wannan Medical College
2022-2024
Beijing University of Technology
2024
Nanjing University of Chinese Medicine
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2024
Metabolic reprogramming shapes tumor microenvironment (TME) and may lead to immunotherapy resistance in pancreatic ductal adenocarcinoma (PDAC). Elucidating the impact of cancer cell metabolism TME is essential therapeutic interventions. "Immune cold" PDAC characterized by elevated lactate levels resulting from metabolism, abundance pro-tumor macrophages, reduced cytotoxic T TME. Analysis 18F-FDG uptake patients showed that increased global protein lactylation correlates with worse clinical...
Rare lipoprotein A (RlpA) is a widely conserved outer membrane protein of unknown function that has previously only been studied in Escherichia coli, where it localizes to the septal ring and scattered foci along lateral wall, but mutants have no phenotypic change. Here we show rlpA Pseudomonas aeruginosa form chains short, fat cells when grown low osmotic strength media. These morphological defects indicate RlpA needed for efficient separation daughter maintenance rod shape. Analysis...
Glioma incidence in the US seems to have stabilized over past 20 years. It's also not clear whether changes glioblastoma are associated with glioma mortality trends. Our study investigated trends and according tumor characteristics.This obtained data from Surveillance, Epidemiology, End Results-9 (SEER-9) registries calculate Annual percent (APC) 95% CIs were calculated using Joinpoint program.62,159 patients (34,996 males 55,424 whites) diagnosed during 1975-2018, 31,922 deaths occurred...
Eosinophils are granulocytes that play an essential role in type 2 immunity and regulate multiple homeostatic processes the small intestine (SI). However, signals eosinophil activity SI at steady state remain poorly understood. Through transcriptome profiling of eosinophils from various mouse tissues, we found a subset expressed neuromedin U (NMU) receptor 1 (NMUR1). Fate-mapping analyses showed NMUR1 expression was programmed by local microenvironment further enhanced inflammation. Genetic...
Abstract Stroke is a leading cause of death, with continuously increasing incidence. As metabolic process that catabolizes glucose pyruvate and provides adenosine triphosphate (ATP), glycolysis plays crucial role in different diseases. Phosphoglycerate kinase 1 (PGK1) facilitates energy production biosynthesis many diseases, including stroke. However, the exact PGK1/glycolysis stroke remains to be elucidated. A rat model middle cerebral artery occlusion (MCAO) was used mimic...
BackgroundLimited data exist on VTE risk and prophylaxis in Chinese inpatients. The Identification of Hospitalized Patients' Risk Profile for Venous Thromboembolism-2 (DissolVE-2), a nationwide, multicenter, cross-sectional study, was therefore designed to investigate prevalence risks evaluate implementation compliant with the latest guidelines (American College Chest Physicians [CHEST], 9th edition).MethodsAdults admitted (≥ 72 h) 60 urban, tertiary hospitals due acute medical conditions or...
Currently, WeChat is widely used in disease education for patients with Crohn's (CD) China. It beneficial the to actively engage their management. In this study, we examined source and expectations of information Chinese CD patients, analysing content popular public accounts potential association medication adherence. Between November 24th, 2017 April 10th, 2018, online questionnaires were sent from eight different large urban hospitals all, 436 surveyed, 342 responded. Patients most...
The increasing incidence of inflammatory bowel disease (IBD) has imposed heavy financial burdens for Chinese patients; however, data about their status and access to health care are still lacking. This information is important informing patients with IBD treatment budgets strategies.The aim this study was evaluate the economic medical through China Crohn's & Colitis Foundation web-based platform in China.Our performed 14 centers mainland between 2018 2019 WeChat. Participants were asked...
OBJECTIVE We aimed to evaluate whether individuals with type 2 diabetes (T2D) were at higher risk of developing a wide range gastrointestinal diseases based on population-based cohort study. RESEARCH DESIGN AND METHODS This study included 374,125 participants free disorders baseline; them, 19,719 (5.27%) T2D followed-up by linking multiple medical records record disease diagnoses. Multivariable Cox models used estimate the hazard ratios (HRs) and CIs. Logistic examine associations between...
ABSTRACT Crohn's disease (CD) is a prevalent type of inflammatory bowel (IBD) with dysregulated antibody responses. However, there lack comprehensive analysis B cell responses in CD. Here, we collected cells from the small intestine, colon and blood CD patients control subjects. Through coupled transcriptome immunoglobulin (Ig) gene individual cells, characterized cellular composition, Ig clonotype different subtypes. We observed shared disruptions plasma (PC) between IBD revealed...
Although large language models (LLMs) such as ChatGPT show promise for providing specialized information, their quality requires further evaluation. This is especially true considering that these are trained on internet text and the of health-related information available online varies widely. The aim this study was to evaluate performance in context patient education individuals with chronic diseases, comparing it industry experts elucidate its strengths limitations. evaluation conducted...
Vaccination plays a crucial role in safeguarding individuals with inflammatory bowel disease (IBD) from potential epidemics. In light of the resurgence COVID-19 China, unvaccinated IBD patients are vulnerable to infection and potentially serious complications. The aim this study is assess vaccination uptake willingness among patients, as well explore factors influencing their decision decline vaccination. An online questionnaire was distributed analyzed. Bivariate analyses logistic...
Introduction: Gastroesophageal reflux disease (GERD) is a prevalent chronic condition primarily treated with proton pump inhibitors (PPIs). However, patients PPI-refractory GERD and hiatal hernia present significant therapeutic challenges, conventional treatments often yielding unsatisfactory outcomes. While anti-reflux mucosectomy (ARMS) has emerged as promising treatment, its efficacy in cases remains understudied. The primary objective of this case report to evaluate the safety ARMS...
The syndrome of high-altitude de-acclimatization commonly takes place after long-term exposure to high altitudes upon return low altitudes. severely affects the returnee's quality life. However, little attention has been paid careful characterization and their underlying mechanisms. Male subjects from Chongqing (n = 67, 180 m) Kunming 70, 1800 visited a area (3650 about 6 months then returned low-altitude. After they came back, all were evaluated for on 3rd, 50th, 100th. Symptom scores,...