A5109895005- Pharmacological Effects of Natural Compounds
- Andrographolide Research and Applications
- Computational Drug Discovery Methods
- Phytochemicals and Medicinal Plants
- Genetic Neurodegenerative Diseases
- Antiplatelet Therapy and Cardiovascular Diseases
- Healthcare Systems and Reforms
- Cerebrovascular and genetic disorders
- Ferroptosis and cancer prognosis
- Acute Myocardial Infarction Research
- Global Health Care Issues
- Cancer Diagnosis and Treatment
- Signaling Pathways in Disease
- Mitochondrial Function and Pathology
- Cancer-related molecular mechanisms research
- Bamboo properties and applications
- Plant Molecular Biology Research
- Phytochemical compounds biological activities
- Inflammatory Myopathies and Dermatomyositis
- Cancer-related gene regulation
- Multiple Sclerosis Research Studies
- Inflammatory Bowel Disease
- Tissue Engineering and Regenerative Medicine
- Flavonoids in Medical Research
- Ginseng Biological Effects and Applications
Zhejiang University
2007-2025
Chinese Academy of Sciences
2010-2025
Shanghai Institute of Materia Medica
2014-2025
University of Chinese Academy of Sciences
2020-2024
Second Affiliated Hospital of Zhejiang University
2020-2024
Shanghai Maritime University
2024
Chinese PLA General Hospital
2015-2023
Anhui University
2023
Shanghai University of Electric Power
2023
The First Affiliated Hospital, Sun Yat-sen University
2017-2021
Human infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes disease 2019 (COVID-19) and there is no cure currently. The 3CL protease (3CLpro) a highly conserved which indispensable for CoVs replication, promising target development of broad-spectrum antiviral drugs. In this study we investigated the anti-SARS-CoV-2 potential Shuanghuanglian preparation, Chinese traditional patent medicine long history treating tract in China. We showed that either oral liquid...
Abstract The ongoing pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2) urgently needs an effective cure. 3CL protease (3CL pro ) is a highly conserved cysteine proteinase that indispensable for replication, providing attractive target developing broad-spectrum antiviral drugs. Here we describe the discovery myricetin, flavonoid found in many food sources, as non-peptidomimetic and covalent inhibitor SARS-CoV-2 . Crystal structures...
The coronavirus disease 2019 (COVID-19) pandemic is an ongoing global health concern, and effective antiviral reagents are urgently needed. Traditional Chinese medicine theory-driven natural drug research development (TCMT-NDRD) a feasible method to address this issue as the traditional formulae have been shown in treatment of COVID-19. Huashi Baidu decoction (Q-14) clinically approved formula for COVID-19 therapy with anti-inflammatory effects. Here, integrative pharmacological strategy was...
Abstract Human infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cause disease 19 (COVID-19) and there is currently no cure. The 3C-like protease (3CLpro), a highly conserved indispensable for replication of coronaviruses, promising target development broad-spectrum antiviral drugs. To advance the speed drug discovery development, we investigated inhibition SARS-CoV-2 3CLpro by natural products derived from Chinese traditional medicines. Baicalin baicalein were...
Colorectal cancer is a common malignancy occurring in the digestive system and ranks second mortality worldwide. In colorectal cancer, hydrogen sulfide (H2S) selectively upregulated, resulting further exacerbation of disease. Therefore, clearance H2S regulation enzymes on pathways are great significance for therapy.Here, we investigated content various clinical tumor tissues from patients confirmed that overproduced concentration cancer. Accordingly, developed an H2S-responsive nanoplatform...
The increasing incidence of inflammatory bowel disease (IBD) has imposed heavy financial burdens for Chinese patients; however, data about their status and access to health care are still lacking. This information is important informing patients with IBD treatment budgets strategies.The aim this study was evaluate the economic medical through China Crohn's & Colitis Foundation web-based platform in China.Our performed 14 centers mainland between 2018 2019 WeChat. Participants were asked...
Bamboo (Phyllostachys praecox) is one of the largest members grass family Poaceae, and most economically important crops in Asia. However, complete knowledge bamboo development its molecular mechanisms still lacking. In present study, differences anatomical structure among rhizome buds, shoots, shoots were compared, several genes related to bud identified. The rice cross-species microarray hybridization showed a total 318 up-regulated 339 down-regulated genes, including those involved...
Four new limonoids (1, 3, 4, 6), named meliatoosenins A−D, eight euphane- and tirucallane-type triterpenoids (8−15), meliasenins A−H, 13 known compounds have been isolated from the stem bark of Melia toosendan. The structures were established on basis 1D 2D NMR experiments (1H−1H COSY, HSQC, HMBC, ROESY).
Adult-onset neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disorder. Abnormally high signals of diffusion-weighted image (DWI) along the corticomedullary junction are useful diagnostic indicator for patients with adult-onset NIID. However, DWI abnormalities usually were observed in late stage disease; further study might be helpful to elucidate some clinical indicators regarding early awareness In this study, we summarized 9 NIID from multiple centers. The mean...
Dear Editor: Here, we demonstrated that cannabinoid receptor 2 (CB2) plays a pivotal role in Schwann cells (SCs) by promoting the remyelination process following peripheral nerve injury (PNI). Selective activation of CB2 shows potential as therapeutic approach to enhance repair these injuries. form Büngner bands guide axonal regeneration during PNI. However, slow pace growth (∼1–3 mm/day) often leads degradation structures within 8 weeks, thereby disrupting regenerative process.1, has been...
Pharmaceutical and Personal Care Products (PPCPs), such as carbamazepine, enter the food chain through wastewater irrigation, posing risks to ecosystems human health. However, research on translocation subcellular distribution of carbamazepine in vegetables is limited. Herein, we used 14C-labeled a tracer investigate its removal, accumulation, compartmentalization hydroponic vegetable systems. Results showed accumulated Chinese flowering cabbage water spinach with removal efficiencies...
Clopidogrel is a thienopyridine derivative and potent inhibitor of ADP-induced platelet aggregation. We compared clopidogrel with aspirin as an adjunctive treatment to tissue-type plasminogen activator (t-PA) for thrombolysis reocclusion. Thrombosis was induced in coronary arteries 32 dogs by injuring the endothelium electric charge. Coronary blood flow velocity monitored pulsed Doppler probe placed around artery. After artery had been occluded thrombus 3 continuous hours, each animal given...
Ten new cassane-type diterpenoids, caesalbonducins D–F (1–3), 6-deacetoxybonducellpin B (4), 3-acetoxy-α-caesalpin (5), 2(3)-en-α-caesalpin (6), 1α-hydroxycaesalpinin J (7), 1α-hydroxy-6-decaetoxysalpinin (8), 6α-hydroxycaesall M (9), and 6α-hydroxy-14(17)-dehydrocaesalpin F (10), along with eight known compounds (11–18), were isolated from the pericarps of Caesalpinia bonduc. Compounds 1–3 11 are methyl-migrated diterpenoids a 19(4→3)-cassane skeleton. The structures 1–10 elucidated on...
Mesenchymal stem cells (MSCs), due to their tumor tropism, are strongly recruited by various solid tumors and mobilized inflammatory signals in the microenvironment. However, effective cellular uptake is critical for MSC-based drug delivery. In this study, we synthesized a spherical copolymer, polyethylenimine-poly(ε-caprolactone), with aggregation-induced emission (AIE) material anticancer drug, paclitaxel, coloaded onto its inner core. This was followed addition of transactivator...
Physalis minima is a medicinal and edible plant in China. In this study, 22 new withaphysalins, including novel 1(10 → 6)abeo-14β-hydroxy one (1) other 15 unusual 14β-hydroxy ones (3-4, 6-17, 19), were isolated from the whole herbs of P. together with two known analogues (23-24). Their structures established by extensive analysis high-resolution electrospray ionization mass spectrometry, IR, 1D 2D NMR spectroscopic data. absolute configurations determined electronic circular dichroism (ECD)...
The objectives of this study were to test the hypotheses that thrombin inhibitors 1) enhance tissue-type plasminogen activator (t-PA)-induced coronary thrombolysis and 2) prevent or delay artery reocclusion. Seventy-one dogs developed occlusive thrombi after introducing a copper coil into left anterior descending (LAD). Coronary blood flows monitored by an externally positioned pulsed Doppler flow probe. t-PA was given with without heparin at different times LAD occlusions. In some...
This study aimed to summarize our experience in surgical treatment of mesh infection after repair ventral hernia or defect. A retrospective analysis was conducted on clinical data 22 patients who accepted defect repair. Included were 16 cases incisional repair, 5 abdominal wall following tumor resection, and 1 case with fistula caused by a parastomal an ileal neobladder prosthetic patch. All had received local dressing for 2 24 months but not healed. The affected removed successfully all...