A5100364292- Inflammatory Bowel Disease
- Genetics and Neurodevelopmental Disorders
- Eosinophilic Esophagitis
- COVID-19 epidemiological studies
- Vaccine Coverage and Hesitancy
- Genomic variations and chromosomal abnormalities
- SARS-CoV-2 and COVID-19 Research
- Stoma care and complications
- Global Health Care Issues
- Autism Spectrum Disorder Research
- Connective tissue disorders research
- Yersinia bacterium, plague, ectoparasites research
- Autoimmune and Inflammatory Disorders
- Microscopic Colitis
- Immune Response and Inflammation
- Healthcare Systems and Reforms
- Helicobacter pylori-related gastroenterology studies
- Vibrio bacteria research studies
- NF-κB Signaling Pathways
- Veterinary Equine Medical Research
- Fibroblast Growth Factor Research
- COVID-19 Pandemic Impacts
- Sarcoidosis and Beryllium Toxicity Research
- Mesenchymal stem cell research
- Congenital heart defects research
Chinese PLA General Hospital
2024
Second Affiliated Hospital of Zhejiang University
2012-2023
XinHua Hospital
2023
Shanghai Jiao Tong University
2023
Clemson University
2023
Shanghai First People's Hospital
2023
Jiangnan University
2023
Zhongnan University of Economics and Law
2022
Children's Hospital of Zhejiang University
2022
China Medical University
2022
Mercury (Hg) is a widespread heavy metal causing various damages to health, while insufficient studies assessed its exposure risk across China. This study explored concentrations in food items and dietary risks China by comprehensively analyzing the researches on total Hg (THg) eight methylmercury (MeHg) aquatic foods published between 1980 2021. According included 695 studies, average THg concentration all was 0.033 mg/kg (ranging from 0.004 0.185 mg/kg), with highest edible fungi. The...
Currently, WeChat is widely used in disease education for patients with Crohn's (CD) China. It beneficial the to actively engage their management. In this study, we examined source and expectations of information Chinese CD patients, analysing content popular public accounts potential association medication adherence. Between November 24th, 2017 April 10th, 2018, online questionnaires were sent from eight different large urban hospitals all, 436 surveyed, 342 responded. Patients most...
The increasing incidence of inflammatory bowel disease (IBD) has imposed heavy financial burdens for Chinese patients; however, data about their status and access to health care are still lacking. This information is important informing patients with IBD treatment budgets strategies.The aim this study was evaluate the economic medical through China Crohn's & Colitis Foundation web-based platform in China.Our performed 14 centers mainland between 2018 2019 WeChat. Participants were asked...
Patients with inflammatory bowel disease (IBD)-related stoma face physical, psychological, and social adjustment challenges. However, knowledge about stigmatization self-management, which is important for clinical care patient education strategies, lacking.To evaluate the level of stigma self-management ability Chinese patients IBD-related using an online questionnaire.Participants were recruited from two general hospitals in mainland China internet platforms Crohn's Colitis Foundation...
Background To understand the awareness of COVID-19 vaccine, willingness to vaccinate and influencing factors in inflammatory bowel disease (IBD) patients. Methods The online questionnaire was distributed conduct a survey analyze evaluate willingness, trust vaccines IBD Bivariate analyses logistic regression models were used analysis factors. Results We sent WeChat group for patient management 304 patients responded, out which 16 respondents had be excluded 288 included analysis. Among them,...
The mammalian immune system has the ability to discriminate between pathogens and innocuous microbes by detecting conserved molecular patterns. In addition microbial patterns, may recognize distinct pathogen-induced processes through a mechanism which is poorly understood. Previous studies have shown that type III secretion (T3SS) in Yersinia pseudotuberculosis leads decreased survival of this bacterium primary murine macrophages unknown mechanisms. Here, we use colony forming unit assays...
DATA REPORT article Front. Environ. Sci., 14 September 2022Sec. Environmental Economics and Management https://doi.org/10.3389/fenvs.2022.951505
Background: Previous studies suggested that anti-TNF drugs might be repurposed as a preventive treatment for colorectal cancer. We aimed to examine whether genetically proxied inhibition of tumor necrosis factor receptor 1 (TNFR1) reduces the absolute risk cancer through mendelian randomization (MR) analysis. Methods: obtained 28 single nucleotide polymorphisms (SNPs) were located within ±15 kilobase window TNFRSF1A—the gene encodes TNFR1 protein, and we used genetic data from three GWAS...
Endoscopic injection is one of the simplest minimally invasive methods for treatment gastroesophageal diseases. However, safety material limits its clinical application. We investigated feasibility, and efficacy endoscopic autogenous fat transplantation (EAFT) in lower part esophagus reflux disease New Zealand albino rabbits. Eight rabbits were used transplantation. The dynamic pH value was monitored before week after two local retention observed by endoscopy, pathological analysis made at...
Interleukin‑1 receptor‑associated kinase‑3 (IRAK‑3) is a negative regulator in Toll‑like receptor (TLR) pathways. The present study investigated the importance of IRAK‑3 mouse model chemically‑induced colitis‑associated tumorigenesis. tumorigenesis was induced ICR mice by administration 1,2‑dimethyl hydrazine (DMH) and dextran sodium sulfate (DSS), termed DMH + DSS group. In group, were administered with DSS; injected DMH; control physiological saline. clinical signs examined for 20 weeks;...
The ankyrin repeat and sterile alpha motif domain containing 6 (ANKS6) gene, encoding an inversin compartment protein of the primary cilium, was recently reported as a pathogenic gene nephronophthisis (MIM PS256100). Extrarenal manifestations are frequently observed in this disease, however, potential genotype-phenotype correlations underlying mechanisms remain poorly understood. Here we described infant with kidney failure, hepatobiliary abnormalities, heart whom whole exome sequencing...
COVID-19 has been prevalent worldwide for about 2 years now and brought unprecedented challenges to our society. Before vaccines were available, the main disease intervention strategies non-pharmaceutical. Starting December 2020, in Ontario, Canada, approved administering vulnerable individuals gradually expanded all above age of 12. As vaccine coverage reached a satisfactory level among eligible population, normal social activities resumed schools reopened starting September 2021. However,...
Background: The coronavirus disease 2019 (COVID-19) pandemic has exposed healthcare workers (HCWs) to serious infection risks. aims of our study were investigate the epidemiological and clinical characteristics COVID-19 among HCWs, evaluate occupational risk factors associated with during Omicron in Shanghai, China.Methods: An active surveillance was performed HCWs who worked Shanghai General Hospital from December 2022 January 2023. A case control conducted by questionnaire survey analyze...
Purpose: To determine the role of Fragile X-related protein-1 (FXR1) in colon cancer progression and its relationship to patients’ survival.Methods: A total 164 colorectal (CRC) patients, admitted Affiliated Hospital Jiangnan University, Wuxi, Jiangsu, China between 2006 2008, were included this study. Immunohistochemistry was used semi-quantitatively analyze intensity extent immunological staining diaminobenzidine-stained paraffin blocks CRC samples. The study also retrieved COAD mRNA...
Signaling pathways have been shown to participate in the process of Retinoic acid (RA) - induced cleft palate (CP). In our current study, signaling molecules GSK-3β, Fzd3 and β-TrCP, which all relate with Wnt pathway, were screened from tissues RA-induced CP mice by Gene-chip Technology. But, their expression pattern level palates during perinatal stages not known yet. studies, mRNA β-TrCP detected quantitative real-time PCR, showed significant difference between Embryonic day 18 (ED18)...