A5101929262- Alzheimer's disease research and treatments
- Amyotrophic Lateral Sclerosis Research
- Parkinson's Disease Mechanisms and Treatments
- Cancer, Hypoxia, and Metabolism
- Autophagy in Disease and Therapy
- Cervical Cancer and HPV Research
- Cancer Cells and Metastasis
- Neuroinflammation and Neurodegeneration Mechanisms
- Barrier Structure and Function Studies
- Molecular Biology Techniques and Applications
- Neuroendocrine Tumor Research Advances
- COVID-19 and healthcare impacts
- Kruppel-like factors research
- Axon Guidance and Neuronal Signaling
- Cancer Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Adipose Tissue and Metabolism
- Lysosomal Storage Disorders Research
- Esophageal Cancer Research and Treatment
- Acute Lymphoblastic Leukemia research
- Hematopoietic Stem Cell Transplantation
- Glycosylation and Glycoproteins Research
- Long-Term Effects of COVID-19
- Acute Myeloid Leukemia Research
- Eosinophilic Disorders and Syndromes
Mianyang Central Hospital
2021-2025
University of Electronic Science and Technology of China
2025
Cornell University
2018-2024
Dongfeng General Hospital
2022
Hubei University of Medicine
2022
Guangzhou Medical University
2022
Guangzhou First People's Hospital
2022
Weatherford College
2021
Air Force Medical University
2021
Affiliated Hospital of North Sichuan Medical College
2021
Advanced or metastatic esophageal cancer (EC) is associated with poor prognosis, necessitating new and effective treatment methods. We assess whether claudin 6 (CLDN6) a useful target for the imaging radiopharmaceutical therapy of EC using novel pair radioactive nuclides, <sup>89</sup>Zr <sup>177</sup>Lu. <b>Methods:</b> CLDN6 messenger RNA expression was evaluated in 2 datasets (<i>n</i> = 436) through retrospective analysis 109 patients EC. then used an anti-CLDN6 monoclonal antibody...
Tight junctions (TJs) are an important component of cell connectivity; they maintain polarity, permeability and adhesion, participate in the regulation proliferation differentiation. The claudin (CLDN) family is integral to TJs, CLDN6 member this family. Abnormal expression can destroy integrity TJs through various mechanisms serve multiple roles occurrence development tumours. widely expressed tumours but rarely healthy adult tissues. aim review critically examine recent literature on...
Abstract Background Haploinsufficiency of progranulin (PGRN) is a leading cause frontotemporal lobar degeneration (FTLD). PGRN comprised 7.5 granulin repeats and processed into individual peptides in the lysosome. However, very little known about levels regulations due to lack specific antibodies. Results Here we report generation characterization antibodies each peptide. We found that granulins C, E F are regulated differently compared A B various tissues. The vary different brain regions...
Hypertension, as the most common comorbidity for patients with coronavirus disease 19 (COVID-19), has resulted in cases more severe symptoms and higher mortality. The risk factors associated COVID-19 hypertension are unknown.All available confirmed from February 3 to March 10, 2020, were enrolled Huoshenshan Hospital, Wuhan, China. demographic characteristics, clinical manifestations, laboratory data, radiological assessments, treatments on admission extracted compared. Univariate...
Mutations in the granulin (GRN) gene, resulting haploinsufficiency of progranulin (PGRN) protein, are a leading cause frontotemporal lobar degeneration (FTLD) and PGRN polymorphisms associated with Alzheimer's disease (AD) Parkinson's (PD). is key regulator microglia-mediated inflammation but mechanism still unknown. Here we report that interacts sPLA2-IIA, secreted phospholipase involved inflammatory responses, to downregulate sPLA2-IIA activities levels. expression modifies deficiency...
Abstract To date, no effective biological markers have been identified for predicting the prognosis of esophageal cancer patients. Recent studies shown that eosinophils are independent prognostic factors in some cancers. This study aimed to identify impact squamous cell carcinoma patients treated with concurrent chemoradiotherapy (CCRT). enrolled 136 who received CCRT locally advanced unresectable (ESCC). We evaluated survival time and clinical pathological characteristics eosinophils. The...
Progranulin (PGRN) is a glycoprotein implicated in several neurodegenerative diseases. It highly expressed microglia and macrophages can be secreted or delivered to the lysosome compartment. PGRN comprises 7.5 granulin repeats processed into individual peptides within lysosome, but functions of these are largely unknown. Here, we identify CD68, membrane protein mainly hematopoietic cells, as binding partner PGRN-derived E. Deletion analysis CD68 showed that this interaction mediated by...
The release of circulating tumor cells (CTCs) into vasculature is an early event in the metastatic process and detection CTCs has been widely used clinically. In addition, cancer stem (CSCs) are source distant metastasis. However, relationship between CSCs nasopharyngeal carcinoma (NPC) patients was largely unknown. A total 93 NPC were enrolled this study. peripheral blood detected. expression ALDH1A1 tissues corresponding detected using immunohistochemistry (IHC). prognostic value level...
Canine mammary tumors are the most common neoplasms in intact female dogs. The surgery cannot always solve problem, chemotherapy recommend to these patients. However, could fail because of multidrug resistance (MDR). Through stepwise increasing 5-Fluorouracil (5-FU) concentration culture medium, a 5-FU-resistant canine tumor cell line CMT7364/5-FU was established disclose molecular mechanism drug resistance. Cell morphology, sensitivity drugs, growth curves, expression proteins, and...
Abstract TMEM106B , a gene encoding lysosome membrane protein, is tightly associated with brain aging, hypomyelinating leukodystrophy, and multiple neurodegenerative diseases, including frontotemporal lobar degeneration TDP-43 aggregates (FTLD-TDP). Recently, polymorphisms have been tauopathy in chronic traumatic encephalopathy (CTE) FTLD-TDP patients. However, how influences Tau pathology its neurodegeneration, unclear. Here we show that loss of enhances the accumulation pathological Tau,...
Abstract Haploinsufficiency of progranulin (PGRN) is a leading cause frontotemporal lobar degeneration (FTLD). PGRN comprised 7.5 granulin repeats and processed into individual peptides in the lysosome. However, very little known about levels regulations due to lack specific antibodies. Here we report generation characterization antibodies each peptide. We found that granulins C, E F are differentially regulated compared A B. Furthermore, demonstrated B, C heavily glycosylated glycosylation...
Objective: To evaluate the feasibility of BioPerfectus multiplex real time (BMRT) HPV assay for self-sample cervical cancer screening. Methods: Eight hundreds and thirty-nine self-collected physician-obtained DNA samples from Shenzhen screening trial Ⅳ(SHENCCAST-Ⅳ) study collected during June 2013 to September 2014 were detected by BMRT efficacy. Results: A total 839 women who screened, 804 with complete data was included in study, average age (46±7) years. Of women, positive rates 14...
Abstract Haploinsufficiency of progranulin (PGRN) is a leading cause frontotemporal lobar degeneration (FTLD). PGRN polymorphisms are associated with Alzheimer’s disease (AD). highly expressed in the microglia near Aβ plaques and influences plaque dynamics microglial activation. However, detailed mechanisms remain elusive. Here we report that deficiency reduces human APP levels young male but not female mice. deficient exhibit increased expression markers activation, including CD68,...