A5028561152- PI3K/AKT/mTOR signaling in cancer
- Advanced biosensing and bioanalysis techniques
- Advanced Nanomaterials in Catalysis
- Protein Structure and Dynamics
- Advanced Breast Cancer Therapies
- Cyclopropane Reaction Mechanisms
- Protein Kinase Regulation and GTPase Signaling
- Enzyme Structure and Function
- Immune Cell Function and Interaction
- Luminescence Properties of Advanced Materials
- Organic Light-Emitting Diodes Research
- Retinal Development and Disorders
- Organic Electronics and Photovoltaics
- Carbon and Quantum Dots Applications
- Biosensors and Analytical Detection
- Structural Engineering and Vibration Analysis
- Retinoids in leukemia and cellular processes
- Cancer, Lipids, and Metabolism
- Cell death mechanisms and regulation
- Vibration and Dynamic Analysis
- Electrochemical sensors and biosensors
- Ubiquitin and proteasome pathways
- Photochromic and Fluorescence Chemistry
- Estrogen and related hormone effects
- Chemical Synthesis and Reactions
Boston College
2009-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
University of Washington
2007-2024
Loyola University Chicago
2022-2024
Zhejiang University
2010-2024
Nanjing Medical University
2020-2024
The University of Texas MD Anderson Cancer Center
2011-2024
Stevens Institute of Technology
2017-2023
University of Rochester
2022
Cornell University
2022
Catalytic carbene transfer to olefins is a useful approach synthesize cyclopropanes, which are key structural motifs in many drugs and biologically active natural products. While catalytic methods for olefin cyclopropanation have largely relied on rare transition-metal-based catalysts, recent studies demonstrated the promise synthetic value of iron-based heme-containing proteins promoting these reactions with excellent activity selectivity. Despite this progress, mechanism iron-porphyrin...
Titanium carbide quantum dots (Ti3C2 QDs) derived from two-dimensional (2D) Ti3C2Tx (MXene) are the rising-star material recently. Herein, nitrogen-doped Ti3C2 QDs (N-Ti3C2 were synthesized via a solvothermal method. The obtained N-Ti3C2 exhibited excitation-dependent photoluminescence, antiphotobleaching, and dispersion stability. Furthermore, by combining DAP (2,3-diaminophenazine, oxidative product of o-phenylenediamine) as composite nanoprobe QDs@DAP), we developed dual-emission reverse...
Nanozymes possess multi-enzyme activities over the natural enzymes, which produce multi-pathway synergistic effects for varies of biomedical applications. Unfortunately, their are in fighting, significantly reducing effects. Dynamic regulation is bottleneck intelligent therapies. Herein, we construct a novel oxygen-nitrogen functionalized carbon quantum dots (O/N-CQDs) with peroxidase-like (Reactive oxygen species (ROS) producer) activity. Interestingly, activity can be reversibly converted...
Recent advances in metalloprotein engineering have led to the development of a myoglobin-based catalyst, Mb(H64V,V68A), capable promoting cyclopropanation vinylarenes with high efficiency and diastereo- enantioselectivity. Whereas many enzymes evolved nature often exhibit catalytic proficiency exquisite stereoselectivity, how these features are achieved for non-natural reaction has remained unclear. In this work, structural determinants responsible chiral induction stereocontrol...
Abstract Non‐small‐cell lung cancer ( NSCLC ) is one of the most common and lethal malignant tumours worldwide with a poor 5‐year survival rate. Recent studies indicated that mi RNA s have been involved in tumorigenic driver pathways , but relevant molecular mechanisms are not well‐understood. In this study, we investigated biological functions miR‐138 human . The effects on cell growth epithelial‐mesenchymal transition EMT were first examined. Then targeting connections G‐protein‐coupled...
Drug resistance to approved systemic therapies in estrogen receptor–positive (ER+) breast cancer remains common. We hypothesized that factors present the human tumor microenvironment (TME) drive drug resistance. Screening of a library recombinant secreted microenvironmental proteins revealed fibroblast growth factor 2 (FGF2) as potent mediator anti-estrogens, mTORC1 inhibition, and phosphatidylinositol 3-kinase inhibition ER+ cancer. Phosphoproteomic analyses identified ERK1/2 major output...
Integration of cellular and humoral arms the innate immune response is fundamental to development powerful effector functions in host defence as well aberrant responses. Here, we provide evidence support relationship between complement activation NK cell functional modulation. We demonstrate that human cells both CD56(bright)CD16(-) CD56(dim)CD16(+) populations express receptors known detect biologically active peptides C3a C5a (i.e. C3aR, C5aR, C5L2) covalently-bound fragments C3b...
Abstract Nanozymes possess multi‐enzyme activities over the natural enzymes, which produce multi‐pathway synergistic effects for varies of biomedical applications. Unfortunately, their are in fighting, significantly reducing effects. Dynamic regulation is bottleneck intelligent therapies. Herein, we construct a novel oxygen‐nitrogen functionalized carbon quantum dots (O/N‐CQDs) with peroxidase‐like (Reactive oxygen species (ROS) producer) activity. Interestingly, activity can be reversibly...
Abstract Regulating cardiolipin to maintain mitochondrial homeostasis is a promising strategy for addressing Parkinson's disease (PD). Through comprehensive screening and validation process involving multiple models, ginsenoside Rg3 (Rg3) as compound capable of enhancing levels identified. This augmentation in fosters by bolstering unfolded protein response, promoting mitophagy, oxidative phosphorylation. Consequently, this cascade enhances the survival tyrosine hydroxylase positive (TH + )...
In this paper, we perform asymptotic analyses of the widely used ESPRIT direction-of-arrival (DoA) estimator for large arrays, where array size $N$ and number snapshots $T$ grow to infinity at same pace. large-dimensional regime, sample covariance matrix (SCM) is known be a poor eigenspectral population covariance. We show that classical algorithm, relies on SCM, as consequence inconsistency produces inconsistent DoA estimates $N,T \to \infty$ with $N/T c \in (0,\infty)$, both widely-...
Molar conductivities are one of the fundamental transport properties electrolytes that reflect complex and dynamic interactions between ions solvents comprehensively. The quantitative accuracy experimental input-free simulations molar is strongly influenced by underlying interaction parameters employed in model. When validated with conductivities, developed model could be used to reveal further atomistic level details about solvation structures correlated ion pair formation, providing...
A deep molecular-level understanding of the multivalent electrolyte and its correlation with electrochemical properties is crucial for designing optimized electrolytes next-generation rechargeable batteries. Comprehensive knowledge atomic level solvation structure connection stability ion transport especially critical. However, interaction these three components coupled clear atomistic insights lacking in literature. Our current contribution evaluates representative...
Abstract Immunotherapy profoundly impacted cancer treatments by harnessing the patient’s immune system. Phagocytosis, process whereby cells engulf and destroy foreign particles or cells, plays a critical role in tumour cell clearance. Herein, we introduce novel concept termed “ENPHASYS” – En hancement of Pha gocytic Sy napse s designed to direct amplify phagocytosis using heterobifunctional molecules named phagocytic synapse enhancers (PSEs). By engineering de novo PD-L1 binder linked...
HeLa cells treated with celastrol, a natural compound inhibitive effect on proteasome, exhibited increase in apoptotic rate and characteristics of apoptosis. To clarify the signal network activated by celastrol to induce apoptosis, both direct target proteins undirect were searched present study. Proteasome catalytic subunit β1 was predicted computational analysis be possible confirmed checking activity recombinant human proteasome vitro. Undirect target-related using proteomic studies...
The human hepatocellular carcinoma (HCC) represents biologically aggressive and chemo-resistant cancers. Owing to the low affinity with apoptotic factor Mcl-1, BH3 mimetic drug ABT-737 failed exert potent cancer-killing activities in variety of cancer models including HCC. current study demonstrated that combining Celastrol synergistically suppressed HCC cell proliferation, induced apoptosis which was accompanied activation caspase cascade release cytochrome c from mitochondria. Further...