A5077175816- Bacterial Infections and Vaccines
- Reproductive tract infections research
- Advanced biosensing and bioanalysis techniques
- Polysaccharides and Plant Cell Walls
- Vibrio bacteria research studies
- Pneumonia and Respiratory Infections
- Biosensors and Analytical Detection
- RNA modifications and cancer
- Respiratory viral infections research
- Aquaculture disease management and microbiota
- Polysaccharides Composition and Applications
- Microbial infections and disease research
- Genital Health and Disease
- Cervical Cancer and HPV Research
- RNA and protein synthesis mechanisms
- Fungal Biology and Applications
- Cancer-related Molecular Pathways
- Microbial Metabolites in Food Biotechnology
- Bacterial Genetics and Biotechnology
- Child Nutrition and Water Access
- Advanced Nanomaterials in Catalysis
- MicroRNA in disease regulation
- Chronic Kidney Disease and Diabetes
- Galectins and Cancer Biology
- Innovative Microfluidic and Catalytic Techniques Innovation
Zunyi Medical University
2017-2024
Affiliated Hospital of Guizhou Medical University
2019-2020
Affiliated Hospital of Zunyi Medical College
2013-2018
Chongqing Medical University
2012-2013
Ministry of Education of the People's Republic of China
2012
First Affiliated Hospital of GuangXi Medical University
2011
Guangxi Medical University
2011
Abstract There is a high mortality and long hospitalization period for severe cases with 2019 novel coronavirus disease (COVID-19) pneumonia. Therefore, it makes sense to search potential biomarker that could rapidly effectively identify early. Clinical samples from 28 of COVID-19 (8 cases, 20 mild cases) in Zunyi District January 29, 2020 February 21, were collected otherwise statistically analysed biochemical markers. Serum urea, creatinine (CREA) cystatin C (CysC) concentrations patients...
Several microRNAs (miRNAs) are expressed at lower levels in specific tumors, e.g., miR-let-7a non-small cell lung cancer (NSCLC). This makes it challenging to analyze their abundance versus specifically elevated miRNAs. Here, we describe a novel fluorescent biosensor for the highly selective and sensitive detection of constructed by combining miRNA screening assisted duplex-specific nuclease (DSN) with CRISPR-Cas12a system signal amplification. We meticulously designed mismatch first three...
Drug-resistant N. gonorrhoeae is an urgent threat to global public health, and vaccine development the best long-term strategy for controlling gonorrhea. We have previously shown that adhesion penetration protein (App) play a role in adhesion, invasion, reproductive tract colonization of gonorrhoeae. Here, we describe immune response induced by intranasal immunization with passenger translocator fragments App. The recombinant App high titers IgG IgA antibodies serum vaginal washes....
Abstract Persistent human papillomavirus (HPV) infection can lead to cervical intraepithelial neoplasia (CIN) and cancer, posing serious threats the health of women. Although cervicovaginal microbiota is strongly associated with CIN, dynamics during CIN development are unknown. In this retrospective cohort study, we analyzed 3‐year longitudinal data from 72 patients diagnosed a persistent HPV almost all caused by high‐risk types. Patients were categorized into groups ( n = 37), progression...
Abstract KRAS mutations are abnormalities widely found in genomic DNA and circulating tumor (ctDNA) of various types cancers. Thus, highly sensitive detection is great significance disease diagnosis personalized medicine. Here, we developed a ligation-initiated loop-mediated isothermal amplification (LAMP) assaying method for ultrasensitive mutation. In the presence mutant (mutDNA), dumbbell-shaped structure (DSS) formed by specific ligation two substrates (SLS1 SLS2), which act as template...
The type VI secretion system (T6SS) and hemolysin HlyA are important virulence factors in Vibrio cholerae. forkhead-associated (FHA) domain is a conserved phosphopeptide binding that exists many regulatory modules. FHA protein-encoding gene the T6SS cluster regulates assembly of T6SS. This study shows for first time protein TagH plays role controlling hemolytic activity V. cholerae, addition to regulating negatively expression at transcriptional post-translational levels. sites play key...
Herein, a dual channel SPRi biosensor has been developed for the simultaneous and highly sensitive detection of multiplex miRNAs based on SDA DNA-functionalized AuNP signal enhancement.
Abstract Human papillomavirus (HPV) type 81 has recently become one of the most common low‐risk HPV types; however, literature focusing on it is limited. This study aimed to analyze reasons for increased detection rate HPV81 and investigate its evolving pathogenicity. We analyzed rates trends in 229 061 exfoliated cervical cell samples collected from 2014 2023; single infections two different time periods; allele frequencies, positive selection, viral load, persistent infection capacity,...
In bacteria, DegS protease functions as an activating factor of the σ E envelope stress response system, which ultimately activates transcription genes in cytoplasm. On basis high-throughput RNA sequencing, we have previously found that degS knockout inhibits expression flagellum synthesis- and chemotaxis-related genes, thereby indicating may be involved regulation V. cholerae motility. this study, examined relationships between motility . Swimming chemotaxis assays revealed or rpoE deletion...
Pathogenic bacteria produce a wide variety of virulence factors that are considered to be potential antibiotic targets. In this study, we report the crystal structure novel S. pneumoniae factor, GHIP, which is streptococcus-specific glycosyl hydrolase. This exhibits an α/β-barrel fold slightly differs from other characterized hydrolases. The GHIP active site, located at negatively charged groove in barrel, very similar site known peptidoglycan Functionally, exhibited weak enzymatic activity...