A5028875385- Inflammasome and immune disorders
- Asthma and respiratory diseases
- Escherichia coli research studies
- Antibiotic Resistance in Bacteria
- Mycobacterium research and diagnosis
- Genetics, Aging, and Longevity in Model Organisms
- Immune Cell Function and Interaction
- Phagocytosis and Immune Regulation
- Immune cells in cancer
- Child Nutrition and Water Access
- Infections and bacterial resistance
- Vibrio bacteria research studies
- CRISPR and Genetic Engineering
- Autophagy in Disease and Therapy
- Microbial Metabolic Engineering and Bioproduction
Shenyang Agricultural University
2024
Zunyi Medical University
2022-2023
The CRISPR/Cas9 systems have been developed as tools for genetic engineering and metabolic in various organisms. In this review, aspects of Saccharomyces cerevisiae, from basic principles to practical applications, summarized. First, a comprehensive review has conducted on the history CRISPR/Cas9, successful cases gene disruptions, efficiencies multiple DNA fragment insertions. Such advanced accelerated development microbial by reducing time labor, enhanced understanding molecular genetics....
Efferocytosis can resolve airway inflammation and enhance tolerance in allergic asthma. While previous work has reported that progranulin (PGRN) regulated macrophage efferocytosis, but it is unclear whether PGRN-mediated efferocytosis associated with Here, we found an ovalbumin (OVA)-induced asthma model, the was suppressed apoptosis lung tissues ameliorated PGRN-deficient mice. In contrast, PGRN knockdown human bronchial epithelial cells increased vitro. Furthermore, macrophages had...
The type VI secretion system (T6SS) and hemolysin HlyA are important virulence factors in Vibrio cholerae. forkhead-associated (FHA) domain is a conserved phosphopeptide binding that exists many regulatory modules. FHA protein-encoding gene the T6SS cluster regulates assembly of T6SS. This study shows for first time protein TagH plays role controlling hemolytic activity V. cholerae, addition to regulating negatively expression at transcriptional post-translational levels. sites play key...
Allergic asthma is an airway inflammatory disease dominated by type 2 immune responses and there currently no curative therapy for asthma. CD5-like antigen (CD5L) has been known to be involved in a variety of diseases. However, the role CD5L allergic remains unclear. In present study, mice were treated with recombinant (rCD5L) during house dust mite (HDM) ovalbumin (OVA) challenge determine asthma, underlying mechanism was further explored. Compared PBS group, serum levels asthmatic...
Carbapenem-resistant hypermucoviscous Klebsiella pneumoniae (CR-HMKP) poses unprecedented public health challenges. However, genomic information regarding the CR-HMKP K2-ST375 strain is scarce. The aim of this study was to characterize whole genome sequence Kp0179 isolated from a male patient in China.