A5034338177- Cancer therapeutics and mechanisms
- Nanoparticle-Based Drug Delivery
- Bioactive Compounds and Antitumor Agents
- HER2/EGFR in Cancer Research
- Click Chemistry and Applications
- Cancer Treatment and Pharmacology
- Nanoplatforms for cancer theranostics
- Synthesis and biological activity
- Histone Deacetylase Inhibitors Research
- Protein Degradation and Inhibitors
- Synthetic Organic Chemistry Methods
- Chemical Synthesis and Analysis
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Molecular Sensors and Ion Detection
- Natural product bioactivities and synthesis
- 14-3-3 protein interactions
- Ginseng Biological Effects and Applications
- Carbohydrate Chemistry and Synthesis
- Cancer, Hypoxia, and Metabolism
- Peptidase Inhibition and Analysis
- Graphene and Nanomaterials Applications
- Lung Cancer Research Studies
- Adenosine and Purinergic Signaling
- Chemical Reaction Mechanisms
East China Normal University
2016-2025
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2025
University of Electronic Science and Technology of China
2025
Nanjing University of Posts and Telecommunications
2022-2024
The Synergetic Innovation Center for Advanced Materials
2023-2024
Shanghai Zhangjiang Laboratory
2024
Fudan University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Jiangsu Agri-animal Husbandry Vocational College
2024
Chinese Academy of Sciences
2004-2023
A series of novel benzimidazole derivatives was synthesized and evaluated for their anti-hepatitis B virus (HBV) activity cytotoxicity in vitro. Strong against HBV replication low were generally observed these benzimidazoles. The most promising compounds 12a 12b, with similar high antiviral potency (IC50 = 0.9 0.7 μM, respectively) remarkable selectivity indices (>1111 714, respectively). They selected further evaluation as inhibitors.
PtSe2, a layered two-dimensional transition-metal dichalcogenide (TMD), has drawn intensive attention owing to its layer-dependent band structure, high air stability, and spin-layer locking effect which can be used in various applications for next-generation optoelectronic electronic devices or catalysis applications. However, synthesis of PtSe2 is highly challenging due the low chemical reactivity Pt sources. Here, we report vapor deposition monolayer single crystals on MoSe2. The periodic...
A catalytic Fe(III)/Fe(II) redox cycling approach has been examined and applied towards synthesis of a wide range benzimidazole, bis-benzimidazole imidazopyridine derivatives from oxidative coupling aromatic ortho-diamines with as well heterocyclic aldehydes bearing different types substituents. This versatile convenient method further proven to be particularly useful in expeditiously affording number novel class Hoechst 33 258 analogs potential development fluorescent nucleic acid binding...
An 88-kDa corrinoid/iron-sulfur protein (C/Fe-SP) is the methyl carrier in acetyl-CoA pathway of Clostridium thermoaceticum. In previous studies, it was found that this C/Fe-SP contains (5-methoxybenzimidazolyl)cobamide and a [4Fe-4S]2+/1+ center, both which undergo redox cycling during catalysis, benzimidazole base uncoordinated to cobalt (base off) all three states, 3+, 2+, 1+ [Ragsdale, S.W., Lindahl, P.A., & Münck, E. (1987) J. Biol. Chem. 262, 14289-14297]. paper, we have determined...
Abstract Purpose: This study aimed to evaluate antitumor activities and pharmacologic profiles of chimmitecan, a novel 9-small-alkyl–substituted lipophilic camptothecin, in comparison with irinotecan (CPT-11) topotecan. Experimental Design: The vitro cytotoxities chimmitecan human tumor cell lines multidrug resistance (MDR) cells were evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide sulforhodamin B assays. DNA relaxation, cleavage assays, cellular band depletion...
A new practical and concise total synthesis of enantiopure camptothecin SN-38 (14% overall yield, 99.9% ee purity) was described, starting from inexpensive readily available materials. The development column chromatography-free purification achieved in all steps, which offers an economic industrial process to the camptothecin-family alkaloids.
To increase the cellular uptake and drug loading of cellulose nanocrystal (CNC)-based nanomedicines, folate/ cis-aconityl-doxorubicin@polyethylenimine@CNC (FA/CAD@PEI@CNC) nanomedicines were built up by building blocks folate (FA), cis-aconityl-doxorubicin (CAD), polyethylenimine (PEI), CNCs via robust layer-by-layer (LbL) assembly technique. The content (DLC) FA/CAD@PEI@CNC hybrids was 11.3 wt %, which almost 20-fold higher than that CNC-based nano-prodrug we reported previously. showed...
Introduction Cerebral ischemia-reperfusion injury (CIRI) is a complex pathophysiological process with significant morbidity and mortality, there no specific agent. Previous studies have found that arctigenin can play an anti-CIRI role through anti-inflammatory antioxidant effects. This study further explored the mechanism of via EPO/EPOR-JAK2-STAT5 signaling pathway. Methods TTC H&E staining were used to observe infarct volume morphological changes in brain, RT-PCR was detect EPO,...
Abstract Camptothecins (CPT) activate S or G2-M arrest and the homologous recombination (HR) repair pathway in tumor cells. In this process, both checkpoint kinases 1 2 (Chk1 Chk2, respectively) are activated, but their differential roles, especially coordination of control, potential clinic relevance remain to be fully elucidated. study, repairable double-strand breaks were induced human colon cancer HCT116 cells by 1-h exposure 25 100 nmol/L CPT its novel derivative chimmitecan. The...
Malignant tumors remain a significant health threat, with death often occurring as result of metastasis. Cell adhesion is crucial step in the metastatic cascade tumor cells, and interruption this considered to be logical strategy for prevention treatment Celastrol [3-hydroxy-24-nor-2-oxo-1(10),3,5,7-friedelatetraen-29-oic acid], quinone methide triterpene from medicinal plant <i>Tripterygium wilfordii</i>, possesses antitumor activities, whereas underlying mechanism(s) remains elusive. Here,...