A5100336155- Computational Drug Discovery Methods
- Synthesis and bioactivity of alkaloids
- Peptidase Inhibition and Analysis
- Synthesis and biological activity
- Cancer therapeutics and mechanisms
- Pharmacogenetics and Drug Metabolism
- Protease and Inhibitor Mechanisms
- Cardiac Structural Anomalies and Repair
- Synthesis and pharmacology of benzodiazepine derivatives
- Protein Degradation and Inhibitors
- Berberine and alkaloids research
- Cholinesterase and Neurodegenerative Diseases
- Click Chemistry and Applications
- Radiopharmaceutical Chemistry and Applications
- Bioinformatics and Genomic Networks
- Cancer Immunotherapy and Biomarkers
- Radical Photochemical Reactions
- Medical Imaging Techniques and Applications
- CAR-T cell therapy research
- Protein Structure and Dynamics
- Pharmacological Effects of Natural Compounds
- Biosimilars and Bioanalytical Methods
- Melanoma and MAPK Pathways
- Shoulder Injury and Treatment
- Sulfur-Based Synthesis Techniques
Affiliated Hospital of Southwest Medical University
2021-2025
University of North Carolina at Chapel Hill
2022-2024
UNC Lineberger Comprehensive Cancer Center
2024
Nantong University
2021-2024
Arsenal Biosciences (United States)
2023-2024
Southwest Medical University
2013-2024
Jiangnan University
2023
First Affiliated Hospital of Sichuan Medical University
2013-2022
ShanghaiTech University
2021-2022
Imaging Center
2022
Local hypoxia is a common feature of many solid tumors and may lead to unsatisfactory chemotherapy outcomes. Anaerobic bacteria that have an affinity hypoxic areas can be used achieve targeted drug delivery in tumor tissues. In this study, we developed biocompatible bacteria/nanoparticles biohybrid (Bif@DOX-NPs) platform employs the anaerobic Bifidobacterium infantis (Bif) deliver adriamycin-loaded bovine serum albumin nanoparticles (DOX-NPs) into breast tumors. The Bif@DOX-NPs retained...
Background Gallium 68–labeled fibroblast-activation protein inhibitor (68Ga-FAPI), an imaging agent for detecting tumors, represents a promising alternative to fluorine 18 fluorodeoxyglucose (18F-FDG). Purpose To compare the potential efficacy of 68Ga-FAPI PET/CT with that 18F-FDG primary tumor and nodal distant metastases in biliary tract cancer (BTC) explore impact (tumor staging) compared on clinical management BTC. Materials Methods This single-center prospective study was performed at...
Abstract Two genes are synthetic lethal if mutations in both result impaired cell viability, while mutation of either gene does not affect the survival. The potential usage lethality (SL) anticancer therapeutics has attracted many researchers to identify pairs. To include newly identified SLs and more related knowledge, we present a new version SynLethDB database facilitate discovery clinically relevant SLs. We extended first significantly by including through Clustered Regularly Interspaced...
To obtain a high antimalarial activity with neocryptolepine derivatives, modifying and changing the side chains at C11 position varying substituents of an electron-withdrawing or electron-donating nature C2 for SAR study were executed. Installation alkylamino ω-aminoalkylamino groups core was successful. For further variation, aminoalkylamino transformed into corresponding acyclic cyclic carbamides thiocarbamides. These chain modified derivatives tested against CQR (K1) CQS (NF54) Plasmodium...
Currently, fluorine-18-fluorodeoxyglucose ( 18 F-FDG) is the most frequently used diagnostical radiotracer for PET/computed tomography (PET/CT) in ovarian malignancies. However, F-FDG has some limitations. The fibroblast activation protein inhibitor (FAPI) previously demonstrated highly promising results studies on various tumor entities and 68 Ga-labeled FAPI presents a alternative to F-FDG. This study aimed compare performance of Ga-FAPI PET/CT imaging malignancies.A total 27 patients were...
A visible-light-induced method for the construction of heterocyclic scaffolds such as pyrido[1,2-a]indoles and indolizines via sulfonyl radical-triggered relay cyclization without employing any external photocatalyst has been developed. Preliminary mechanistic investigation indicated that indole pyrrole derivatives could serve pre-photocatalysts to promote sulfonylation/cyclization, thereby providing a facile synthesize valuable sulfonylated heterocycles.
In this study, we introduce a practical methodology for the synthesis of PET probes by seamlessly combining flow chemistry with photoredox radiofluorination. The clinical tracer 6-[18F]FDOPA was smoothly prepared in 24.3% non-decay-corrected yield over 99.0% radiochemical purity (RCP) and enantiomeric excess (ee), notably simple cartridge-based purification. chemistry-enhanced photolabeling method supplies an efficient versatile solution more development.
Comprehensive Summary The dearomatization of indole derivatives bearing amide functionalities presents a significant challenge due to the inherent stability carbonyl group, resulting from nitrogen lone‐pair delocalization that imparts increased resonance stabilization. In this study, we report visible‐light photocatalytic intramolecular with groups, achieving synthesis spiroindolines via energy transfer. This method enables efficient formation range hydroxyl‐substituted in moderate high...
Radix Salviae (Dan-shen in pinyin), a classic Chinese herb, has been extensively used to treat diabetic retinopathy clinical practice China for many years. However, the pharmacological mechanisms of remain vague. The aim this study was decrypt underlying treatment using systems pharmacology approach. A network pharmacology-based strategy proposed elucidate multi-component, multi-target, and multi-pathway mode action against retinopathy. First, we collected putative targets based on...
Photoredox is a powerful synthetic tool in organic chemistry and has been widely used various fields, including nuclear medicine molecular imaging. In particular, acridinium-based organophotoredox radiolabeling significantly impacted the production discovery of positron emission tomography (PET) agents. Despite their extensive use preclinical research, no PET agents synthesized by acridinium photoredox labeling have tested humans. [18F]FDOPA clinically for tumor diagnosis evaluation...