A5107250266- Epigenetics and DNA Methylation
- Genetics and Neurodevelopmental Disorders
- Neuroendocrine regulation and behavior
- Neuroscience and Neuropharmacology Research
- Nanoplatforms for cancer theranostics
- MicroRNA in disease regulation
- Nanoparticle-Based Drug Delivery
- Stress Responses and Cortisol
- CAR-T cell therapy research
- Tryptophan and brain disorders
- Circadian rhythm and melatonin
- Signaling Pathways in Disease
- Memory and Neural Mechanisms
- Autophagy in Disease and Therapy
- Cannabis and Cannabinoid Research
- RNA Interference and Gene Delivery
- Soft tissue tumors and treatment
- Mitochondrial Function and Pathology
- Lung Cancer Treatments and Mutations
- Circular RNAs in diseases
- Pluripotent Stem Cells Research
- Dendrimers and Hyperbranched Polymers
- Wnt/β-catenin signaling in development and cancer
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
Jiangnan University
2025
Sir Run Run Shaw Hospital
2016-2025
Zhejiang University
2016-2025
Zhejiang Lab
2025
Shenyang Pharmaceutical University
2024-2025
Army Medical University
2023-2024
Institute of High Energy Physics
2024
University of Chinese Academy of Sciences
2024
Beam Therapeutics (United States)
2024
South China University of Technology
2024
Chronic stress remodels brain homeostasis, in which persistent change leads to depressive disorders1. As a key modulator of homeostasis2, it remains elusive whether and how autophagy is engaged dynamics. Here we discover that acute activates, whereas chronic suppresses, mainly the lateral habenula (LHb). Systemic administration distinct antidepressant drugs similarly restores function LHb, suggesting LHb as common target. Genetic ablation neuronal promotes susceptibility, enhancing exerts...
Abstract Although the link of white matter to pathophysiology schizophrenia is documented, loss myelin not detected in patients at early stages disease, suggesting that pathological evolution may occur before significant loss. Disrupted-in-schizophrenia-1 (DISC1) protein highly expressed oligodendrocyte precursor cells (OPCs) and regulates their maturation. Recently, DISC1-Δ3, a major DISC1 variant lacks exon 3, has been identified patients, although its significance remains unknown. In this...
A significant increase in mitochondrial fatty acid oxidation (FAO) is now increasingly recognized as one of the metabolic alterations diabetic cardiomyopathy (DCM). However, molecular mechanisms underlying FAO impairment DCM remain to be fully elucidated. type 2 diabetes (T2D) mouse model was established by a combination high-fat diet (HFD) and streptozotocin (STZ) injection. Neonatal rat cardiomyocytes were treated with high glucose (HG) palmitic (HP) simulate cardiac injury. Gain-...
Photoacoustic (PA) imaging using contrast agents with strong near-infrared-II (NIR-II, 1000-1700 nm) absorption enables deep penetration into biological tissue. Besides, biocompatibility and biodegradability are essential for clinical translation. Herein, we developed biocompatible biodegradable germanium nanoparticles (GeNPs) high photothermal stability as well broad NIR-II PA imaging. We first demonstrate the excellent of GeNPs through experiments, including zebrafish embryo survival...
Abstract Hepatocellular carcinoma (HCC) is a prevalent malignant tumor with range of risk factors, including viral infections, alcoholic liver disease, exposure to fungal toxins, obesity, and type 2 diabetes. Despite advancements in early detection treatment, HCC continues exhibit high rate recurrence. Patients advanced stages have poor prognosis, the survival after cancer metastasis notably low. Consequently, there exists an urgent necessity for novel treatment strategies. Nanomedicine...
This study aims to clarify the mechanistic actions of microRNA-873-5p (miR-873-5p) on glioblastoma (GBM) progression. The most differentially expressed miRNAs were retrieved from GEO database. It was established that miR-873-5p downregulated in GBM tissues and cells. Based silico prediction experimental data, HMOX1 demonstrated be a target gene miR-873-5p. Further, then ectopically cells examine its effect malignant behaviors Overexpression inhibited cell proliferation invasion by targeting...
Topic: 16. Myeloproliferative neoplasms - Clinical Background: HMPL-306 is a potent selective inhibitor of mutant IDH1/2. Aims: The phase 1 study aimed to evaluate safety, tolerability, recommended 2 (RP2D), pharmacokinetics/pharmacodynamics (PK/PD) and preliminary efficacy in patients (pts) with relapsed/ refractory myeloid hematological malignancies (HMs) carrying IDH1 2. Methods: open-label, multicenter included dose escalation expansion phases. Pts relapsed/refractory HMs and/or were...
Abstract Although the link of white matter to pathophysiology schizophrenia is documented, loss myelin not detected in patients at early stages disease, suggesting that pathological evolution may occur before significant loss. Disrupted-in-schizophrenia-1 (DISC1) protein highly expressed oligodendrocyte precursor cells (OPCs) and regulates their maturation. Recently, DISC1-Δ3, a major DISC1 variant lacks exon 3, has been identified patients, although its significance remains unknown. In this...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a malignant tumor with poor prognosis and high mortality. Although large number of studies have explored its potential prognostic markers using traditional RNA sequencing (RNA-Seq) data, they not achieved good prediction effect. In order to explore the possible signaling pathways leading difference in prognosis, we identified differentially expressed genes from one scRNA-seq cohort four GEO cohorts, respectively. Then Cox Lasso regression...