A5064238716- HIV/AIDS Research and Interventions
- Suicide and Self-Harm Studies
- LGBTQ Health, Identity, and Policy
- Porphyrin Metabolism and Disorders
- Neonatal Health and Biochemistry
- Heme Oxygenase-1 and Carbon Monoxide
- HIV, Drug Use, Sexual Risk
- Mental Health Treatment and Access
- Poxvirus research and outbreaks
- Employment and Welfare Studies
- Forest Management and Policy
- Remote Sensing and LiDAR Applications
- Forest ecology and management
- Sexuality, Behavior, and Technology
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipoproteins and Cardiovascular Health
- Health disparities and outcomes
- Liver Disease Diagnosis and Treatment
- HIV Research and Treatment
- Workplace Health and Well-being
- Impact of Technology on Adolescents
- Animal Disease Management and Epidemiology
- Mental Health Research Topics
- Forest Biomass Utilization and Management
- Resilience and Mental Health
Shanghai Jiao Tong University
2020-2025
Tongren Hospital
2024-2025
Beam Therapeutics (United States)
2024
Anhui Medical University
2024
Shanghai University of Medicine and Health Sciences
2023
Guangzhou Medical University
2019-2022
Alnylam Pharmaceuticals (United States)
2019-2022
Stomatology Hospital
2019-2022
Shanghai Skin Disease Hospital
2021
Université Paris Cité
2019
Up-regulation of hepatic delta-aminolevulinic acid synthase 1 (ALAS1), with resultant accumulation (ALA) and porphobilinogen, is central to the pathogenesis acute attacks chronic symptoms in porphyria. Givosiran, an RNA interference therapy, inhibits ALAS1 expression.In this double-blind, placebo-controlled, phase 3 trial, we randomly assigned symptomatic patients porphyria receive either subcutaneous givosiran (2.5 mg per kilogram body weight) or placebo monthly for 6 months. The primary...
Background and Aims Acute hepatic porphyria comprises a group of rare genetic diseases caused by mutations in genes involved heme biosynthesis. Patients can experience acute neurovisceral attacks, debilitating chronic symptoms, long‐term complications. There is lack multinational, prospective data characterizing the disease current treatment practices severely affected patients. Approach Results EXPLORE prospective, natural history study activity clinical management patients with who...
Background Internet use exhibits diverse trajectories during adolescence, which may contribute to depressive symptoms. Currently, it remains unclear whether the association between internet and symptoms varies urban rural areas. Objective This study aimed investigate adolescent explore variation in this Methods longitudinal used 3-wave data from 2014-2018 China Family Panel Study. Weekly hours of were measured using self-reported questionnaires. Latent class growth modeling was performed...
Abstract Background Acute hepatic porphyria (AHP) is a family of four rare genetic diseases, each involving deficiency in heme biosynthetic enzyme. Resultant overproduction the neurotoxic intermediates δ-aminolevulinic acid (ALA) and porphobilinogen (PBG) leads to disabling acute neurovisceral attacks progressive neuropathy. We evaluated AHP disease burden patients aged ≥ 12 years post hoc analysis Phase 3, randomized, double-blind, placebo-controlled ENVISION trial givosiran (NCT03338816),...
The impact of psychosocial factors on increasing the risk HIV infection among men who have sex with (MSM) has attracted attention. We aimed to develop and validate an integrated prediction model, especially incorporating emerging variables, for predicting MSM. surveyed collected sociodemographic, psychosocial, behavioral information from 547 MSM in China. participants were split into a training set testing 3:1 theoretical ratio. model was constructed by introducing important variables...
Abstract Background Self-efficacy in mpox (formerly known as monkeypox) prevention plays a pivotal role promoting preventive behaviors by fostering sense of control and motivation, especially among men who have sex with (MSM), the population most affected many countries. Objective This study aims to assess self-efficacy MSM China identify factors influencing it, using validated scale. Methods From October 2023 March 2024, nationwide cross-sectional was conducted (aged ≥18 years) across 6...
Vaccine hesitancy is a significant barrier to achieving high vaccination rates, particularly among men who have sex with (MSM), group at increased risk for Mpox. This study aimed develop and validate Mpox vaccine scale specifically tailored Chinese MSM, grounded in the protection motivation theory (PMT).
Abstract Objectives Mesenchymal stem cells (MSCs) based therapy for bone regeneration has been regarded as a promising method in the clinic. However, hBMSCs with invasive harvesting process and undesirable proliferation rate hinder extensive usage. HUCMSCs of easier access excellent performances provide an alternative fabrication tissue‐engineered construct. Evidence suggested osteogenesis ability hUCMSCs was weaker than that hBMSCs. To address this issue, co‐culture strategy osteogenically...
Several studies highlighted childhood sexual experiences (CSEs) and intimate partner violence (IPV) as risk factors that affected lifetime suicidal ideation. TW had higher rates of CSEs IPV than cisgender people. The aim this study was to comprehensively assess the prevalence among their association with ideation.A cross-sectional survey conducted 247 in Shenyang Kunming, China, from April September 2018. CSEs, IPV, ideation were assessed. Logistic regression models used examine between...
Abstract Background Perception of entrapment can emerge when someone feels trapped in an aversive situation and incapable escape. Depression is closely related to the construct entrapment. In China, men who have sex with (MSM) a high prevalence depression; therefore, tool evaluate this population needed. We evaluated validity reliability Chinese version scale (ES) relationship depression among MSM Shanghai, China. Methods recruited 304 from four districts Participants completed health...
Background: Lung adenocarcinoma (LUAD) is the most common subtype of non-small-cell lung cancer (NSCLC). The aim our study was to determine prognostic risk factors and establish a novel nomogram for patients. Methods: This retrospective cohort based on Surveillance, Epidemiology, End Results (SEER) database Chinese multicenter database. We selected 22,368 eligible LUAD patients diagnosed between 2010 2015 from SEER screened them inclusion exclusion criteria. Subsequently, were randomly...
Objective: Interpersonal theories of suicide suggest that the Needs Questionnaire (INQ) can be used to measure suicidal ideation, but few studies have focused on migrant people, a group with high prevalence ideation. The aim this study was validate psychometric properties INQ-15 and its prediction ideation among industrial workers in China. Method: A stratified multi-stage sample 2023 recruited from 16 factories Shenzhen, There were 1805 nonlocal workers, which we defined as mean age 32.50 ±...
Transgender women (TGW) experience serious psychiatric problems and high suicide rates. According to the interpersonal theory of suicide, thwarted belongingness perceived burdensomeness play major roles in suicidality can be measured by Interpersonal Needs Questionnaire (INQ). However, no study has validated use INQ TGW. This aimed examine psychometric properties among We recruited 198 TGW (mean age 38.47 years) from Shenyang, China, using snowball sampling. The construct validity was...
This study aimed to explore relationships between job stress and psychological adaptation how they related interpersonal needs through mood states among female migrant manufacturing workers.A cross-sectional survey was conducted in 16 factories Shenzhen, China. Sociodemographic, stress, other information of collected. Structural equation modeling performed delineate the internal relationship variables.The hypothetical structural model exhibited acceptable fit workers (χ2 = 11.635, df 2,...
Objectives: This study aimed to prospectively investigate gender-specific relationship between hyperuricemia and all-cause mortality among Chinese older adults. Methods: The was based on the Longitudinal Healthy Longevity Survey (CLHLS) 2008-2018, a prospective nationwide cohort of adults in China. Multivariate Cox proportional hazards models were used estimate hazard ratios (HRs) 95% CIs for mortality. Restricted cubic splines (RCS) conducted explore dose-response SUA levels Results: For...
Abstract Three dendrometers are used to measure dbh. Two of the devices well-known and widely d-tape caliper. The third device is lesser-known sector fork. In this study, measurements dbh were collected from each dendrometer for tree in nine plots, with three plots nested one diameter classes (small, medium, large). results repeated-measures analysis variance show that different dendrometers, interaction between class, plot significantly affected measurements. Statistically significant...
Abstract Background Migrant workers are a group susceptible for depression evolution due to occupational maladaptive triggers. The social rank theory illustrates the pathology process from defensive adaptation depression, pointing out early prevention of by discovering entrapment. This study aims reveal relationship between migrant workers’ entrapment and depressive symptoms. Methods A total 1805 in Shenzhen were recruited stratified multi-stage sampling. Sample’s demographic, behavioral...
Studies examining the association between psychosocial problems and condomless anal sex (CAS) among transgender women (TGW) are rare. In this study, close attention was paid to effect of co-occurring on sexual risk behaviors. A cross-sectional including 247 TGW, conducted in Kunming Shenyang, China. The prevalence TGW previous 6 months 30.8%. Most factors were associated with one another bivariate logistic regression models. Low self-esteem (ORm = 2.99, 95% CI 1.25-7.18), compulsivity 2.13,...
Childhood sexual abuse (CSA) is a hidden but serious public health issue that can lead to series of behavioral consequences and problems in adulthood. It has been well documented transgender women (TGW) have high prevalence CSA victimization. Moreover, risky behaviors are also widespread among TGW; nevertheless, research investigating the associations between victimization TGW represents gap literature.
Abstract Objectives This study explores whether feelings of defeat (i.e., a sense failed struggle and losing rank; referred to as for simplicity) mediated the effect work stress on depression/anxiety, interpersonal needs depression/anxiety Chinese industrial workers, possible moderating role social support. Method A cross-sectional was conducted in Shenzhen, China 2019, total, 2023 workers (of 2700 invited; response rate = 75%) completed self-administered survey consisted Job Stress Scale,...
Proper blood lipid levels are essential for survival in older adults, but inconsistent relationships have been reported between lipids and all-cause mortality the elderly.This retrospective longitudinal study analyzed data from 1,067 Chinese adults enrolled Longitudinal Healthy Longevity Survey collected 2008 followed up until death or December 31, 2018. The outcome was mortality. Multivariate Cox regression analyses were used to estimate hazard ratios (HRs) 95% confidence intervals (CIs)...
Suboptimal adherence to antiretroviral therapy (ART) dramatically hampers the achievement of UNAIDS HIV treatment targets. This study aimed develop a theory-informed predictive model for ART based on data from Chinese.A cross-sectional was conducted in Shenzhen, China, December 2020. Participants were recruited through snowball sampling, completing survey that included sociodemographic characteristics, clinical information, Information-Motivation-Behavioural Skills (IMB) constructs and ART....
High prevalence of depression in transgender women highlights the importance validating measure to assess depression. Moreover, is significantly associated with suicide across research studies. The aims current study were validate a Chinese-language version Patient Health Questionnaire-9 (PHQ-9) and operating characteristics PHQ-9 for screening women.
Introduction Men who have sex with men (MSM) are a high-risk group for suicide, much higher prevalence of suicidal ideation (SI) than the general population and male population. The aim this study was to explore risk factors influencing development SI develop validate nomogram among MSM. Methods A cross-sectional conducted in 915 MSM from Shanghai, Shenyang, Shenzhen Kunming, China using snowball sampling method. integrated motivational-volitional (IMV) model behavior used as theoretical...