A5100708295- interferon and immune responses
- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Virology and Viral Diseases
- Myasthenia Gravis and Thymoma
- HIV Research and Treatment
- Virus-based gene therapy research
- COVID-19 Clinical Research Studies
- Corneal Surgery and Treatments
- Immune cells in cancer
- Animal Virus Infections Studies
- T-cell and B-cell Immunology
- SARS-CoV-2 and COVID-19 Research
- Parkinson's Disease and Spinal Disorders
- Phagocytosis and Immune Regulation
- Cancer-related molecular mechanisms research
- Erythrocyte Function and Pathophysiology
- Enzyme Production and Characterization
- Ocular Surface and Contact Lens
- Bacteriophages and microbial interactions
- Inflammasome and immune disorders
- Monoclonal and Polyclonal Antibodies Research
- Ophthalmology and Visual Impairment Studies
- Immunotherapy and Immune Responses
- Extracellular vesicles in disease
Hua Medicine (China)
2025
Hubei Cancer Hospital
2020-2025
Chinese Academy of Sciences
2014-2024
Beike Biotechnology (China)
2024
Inner Mongolia University
2024
First Affiliated Hospital of Jinan University
2003-2024
Henan University of Science and Technology
2024
Yichang Central People's Hospital
2024
China Three Gorges University
2024
Fudan University
1995-2024
Rse, Axl, and c-Mer comprise a family of cell adhesion molecule-related tyrosine kinase receptors. Human Gas6 was recently shown to act as ligand for both human Rse (Godowski et al., 1995) Axl (Varnum 1995). contains an NH2-terminal Gla domain followed by four epidermal growth factor-like repeats tandem globular (G) domains. The G domains are related those found in sex hormone-binding globulin utilized laminin agrin binding the dystroglycan complex. A series variants were tested their...
Abstract The outbreak of Zika virus (ZIKV) in 2016 created worldwide health emergency which demand urgent research efforts on understanding the biology and developing therapeutic strategies. Here, we present a time-resolved chemical proteomic strategy to track early-stage entry ZIKV into host cells. was labeled its surface with probe, carries photocrosslinker covalently link virus-interacting proteins living cells UV exposure at different time points, biotin tag for subsequent enrichment...
ABSTRACT Organoid culture systems are very powerful models that recapitulate in vivo organ development and disease pathogenesis, offering great promise basic research, drug screening precision medicine. However, the application of organoids derived from patients with cancer to immunotherapeutic research is a relatively untapped area. Esophageal one most lethal malignancies worldwide, including two major pathological subtypes: esophageal squamous cell carcinoma (ESCC) adenocarcinoma. ESCC...
Background: Interleukin (IL)-17A, a newly identified cytokine, may participate in the transition of stable plaque into an unstable plaque. Macrophages play critical role destabilization atherosclerotic Methods: RAW 264.7 cells were stimulated with IL-17A. The mRNA expression inflammatory cytokines was determined by RT-PCR. production supernatants measured ELISA. Small interfering RNA (siRNA) used to confirm that IL-17A-induced pro-inflammatory via IL-17RA signaling. western blot assay detect...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of disease 2019 (COVID-19), binds to host receptor angiotensin-converting enzyme (ACE2) through its spike (S) glycoprotein, which mediates membrane fusion and viral entry. However, expression ACE2 is extremely low in a variety human tissues, especially airways. Thus, other coreceptors and/or cofactors on surface cells may contribute SARS-CoV-2 infection. Here, we identified nonmuscle myosin heavy chain IIA...
Zika virus (ZIKV) infection can cause fetal developmental abnormalities and Guillain-Barré syndrome in adults. Although progress has been made understanding the link between ZIKV microcephaly, pathology of ZIKV, particularly viral reservoirs human, remains poorly understood. Several studies have shown that compared to serum samples, patients' urine samples often a longer duration persistency higher load. This finding suggests an independent reservoir may exist human urinary system. Despite...
Transglutaminases (TGase), which are synthesized as a zymogen (pro-TGase) in Streptomyces sp., important enzymes the food industry. Because this pro-peptide is essential for correct folding of TGase, TGase usually expressed an inactive pro-TGase form, then converted to active by addition activating proteases vitro. In study, hygroscopicus was actively produced lividans through promoter engineering and codon optimization. A gene fragment (tg1, 2.6 kb) that encoded its endogenous region,...
Phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P(3)] is a second messenger produced in response to agonist stimulation. Traditionally, visualization of phosphoinositide polyphosphates (PtdInsP(n)) living cells accomplished using chimeric green fluorescent protein (GFP)-pleckstrin homology (PH) domain proteins, while PtdInsP(n) quantitation by extraction and separation radiolabeled cellular PtdInsP(n)s. Here we describe preparation covalent protein-PtdIns(3,4,5)P(3) immunogen,...
This study investigates the protective effects of blueberry anthocyanins against acute liver injury. Cyanidin-3-glucoside, delphinidin-3-rutinoside, and malvidin-3-galactoside, main monomers among anthocyanins, play important roles in cell survival increasing level cellular antioxidant. Results proliferation assay showed that different concentrations protected human embryonic-liver L-02 cells CCl4-induced injury a dose-dependent manner. After 48 h incubation, cells, with IC50 6.2 × mg/L....
The vast majority (>90%) of glioblastoma (GBM) patients belong to the isocitrate dehydrogenase 1 wild type (IDH1WT) group which exhibits a poor prognosis with median survival less than 15 months. This study demonstrated numerous immunosuppressive genes as well β-catenin gene, pivotal for Wnt/β-catenin signaling, were upregulated in 206 IDH1WT glioma using Chinese Glioma Genome Atlas (CGGA) database. increase microglia an phenotype and overexpression protein further verified GBM GL261...
Type I interferons (IFNs) are the first line of defense against viral infection. Using a mouse model influenza A virus infection, we found that IFN-κ was one earliest responding type IFNs after infection with H9N2, low-pathogenic avian virus, whereas this early induction did not occur upon epidemic-causing H7N9 virus. efficiently suppressed replication various viruses in cultured human lung cells, and chromodomain helicase DNA binding protein 6 (CHD6) major effector for antiviral activity...
The latent reservoir of HIV-1 presents a major barrier to viral eradication. mechanism the establishment and maintenance is not yet fully understood, which hinders development effective curative strategies. In this study, we identified two inhibitory genes, TSC1 DEPDC5, that maintained latency by suppressing mTORC1 pathway. We first adapted genome-wide CRISPR screening approach identify host factors required for HIV in T-cell-based model discovered are potentially involved latency. Knockout...
Tanshinone IIA (TIIA) is an active compound that can be isolated from the Chinese herb, Salvia miltiorrhizae Bunge, also known as danshen. Previous studies have demonstrated TIIA effectively attenuate bleomycin‑induced pulmonary fibrosis in rats. However, it has not been determined whether paraquat (PQ)‑induced acute lung injury (ALI). In present study, protective effects exhibited by on PQ‑induced ALI, well its underlying mechanisms, were investigated using Sprague‑Dawley (SD) ALI animal...