A5012293304- Glioma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Ferroptosis and cancer prognosis
- Meningioma and schwannoma management
- Cancer-related molecular mechanisms research
- Neuroinflammation and Neurodegeneration Mechanisms
- Phagocytosis and Immune Regulation
- Neurological Disorders and Treatments
- Neurological Disease Mechanisms and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- S100 Proteins and Annexins
- Digestive system and related health
- Immune cells in cancer
- Pancreatitis Pathology and Treatment
- Colorectal Cancer Treatments and Studies
- Delphi Technique in Research
- Cerebrovascular and genetic disorders
- Gold and Silver Nanoparticles Synthesis and Applications
- Protein Interaction Studies and Fluorescence Analysis
- Liver Disease and Transplantation
- Advanced biosensing and bioanalysis techniques
- Childhood Cancer Survivors' Quality of Life
- Gastrointestinal motility and disorders
- Bipolar Disorder and Treatment
- Chemokine receptors and signaling
First People's Hospital of Nanning
2025
Zunyi Medical University
2024-2025
Fudan University
2019-2024
Huashan Hospital
2021-2024
Nanchang University
2020-2023
First Affiliated Hospital of Nanchang University
2023
Shanghai Center for Brain Science and Brain-Inspired Technology
2021-2022
Center for Excellence in Brain Science and Intelligence Technology
2022
State Key Laboratory of Medical Neurobiology
2021
Shanghai Clinical Research Center
2021
The secondary injury caused by traumatic brain (TBI), especially white matter (WMI), is highly sensitive to neuroinflammation, which further leads unfavored long-term outcomes. Although the cross-talk between three active events, immune cell infiltration, BBB breakdown, and proinflammatory microglial/macrophage polarization, plays a role in vicious cycle, its mechanisms are not fully understood. It has been reported that cordycepin, an extract from Cordyceps militaris, can inhibit...
Glioblastoma is the most common and fatal primary brain tumor in adults. Even with maximal resection a series of postoperative adjuvant treatments, median overall survival (OS) glioblastoma patients remains approximately 15 months. The Huashan Hospital glioma bank contains more than 2000 tissue samples long-term follow-up data; almost half these are from patients. Several large databases data have reported outcomes countries other China. We investigated prognosis China compared among...
Microglia play essential roles in neuroinflammatory responses after traumatic brain injury (TBI). Our previous studies showed that phenotypes of microglia, as well infiltrating macrophages, altered at different stages CNS injury, which was correlated to functional outcomes. IL-13 is an anti-inflammatory cytokine has been reported protect against demyelination and spinal cord through immunomodulation. The effects microglia/macrophage-mediated immune TBI remain unknown. In this study, we...
Glioma is the most frequent form of malignant brain tumors. Surgical debulking a major strategy for glioma treatment. However, there great challenge neurosurgeons to intraoperatively identify true margins because its infiltrative nature. Tumor residues or microscopic satellite foci left in resection bed are main reasons leading early recurrence as well poor prognosis. In this study, surface-enhanced resonance Raman scattering (SERRS) probe was developed guide resection. probe, molecular...
The vast majority (>90%) of glioblastoma (GBM) patients belong to the isocitrate dehydrogenase 1 wild type (IDH1WT) group which exhibits a poor prognosis with median survival less than 15 months. This study demonstrated numerous immunosuppressive genes as well β-catenin gene, pivotal for Wnt/β-catenin signaling, were upregulated in 206 IDH1WT glioma using Chinese Glioma Genome Atlas (CGGA) database. increase microglia an phenotype and overexpression protein further verified GBM GL261...
Abstract Background Glioma is the most common primary brain tumor with high mortality and disability rates. Recent studies have highlighted significant prognostic consequences of subtyping molecular pathological markers using samples, such as IDH, 1p/19q, TERT. However, relative importance individual or marker combinations in affecting patient survival remains unclear. Moreover, cost reliance on postoperative samples hinder widespread use these clinical practice, particularly during...
Abstract Background This study aimed to identify the most valuable predictors of prognosis in glioblastoma (GBM) patients and develop validate a nomogram estimate individualized survival probability. Methods We conducted real-world retrospective cohort 987 GBM diagnosed between September 2010 December 2018. Computer generated random numbers were used assign into training (694 patients) internal validation (293 patients). A least absolute shrinkage selection operator (LASSO)-Cox model was...
Fulminant liver failure (FHF) is a serious clinical problem and transplantation the major intervention. But overall survival rate of FHF low owing to donated organ shortage. Apolipoprotein A-V (ApoA5) regulator triglyceride metabolism has been reported act as predictor for remnant growth after preoperative portal vein embolization surgery. This study aimed investigate therapeutic effect ApoA5 on lipopolysaccharide/d-galactosamine (LPS/d-GalN)—induced fulminant in mice. mouse model was...
Colorectal cancer (CRC) is one of the most lethal malignancies and incidence CRC has been on rise. Herein, we aimed to identify effective biomarkers for early diagnosis treatment colorectal via bioinformatic tools. To differentially expressed genes (DEGs) in CRC, downloaded gene expression data from GSE24514 GSE110223 datasets Gene Expression Omnibus (GEO) employed R analyze data. We further performed functional enrichment analysis DEGs DAVID ontology tool. STRING database Cytoscape...
BackgroundIn the setting of drug-resistant epilepsy (DRE), success surgery depends on ability to accurately locate epileptic foci be resected or disconnected. However, in a considerable percentage DRE patients cannot adequately localised. This warrants need for reliable imaging strategy identify "concealed" regions.MethodsBrain specimens from and kainate-induced mouse models were immuno-stained evaluate integrity blood-brain barrier (BBB). The expression low-density lipoprotein...
Abstract Background Glioma recurrence, subsequent to maximal safe resection, remains a pivotal challenge. This study aimed identify key clinical predictors influencing recurrence and develop predictive models enhance neurological diagnostics therapeutic strategies. Methods longitudinal cohort with substantial sample size ( n = 2825) included patients non-recurrent glioma who were pathologically diagnosed had undergone initial surgical resection between 2010 2018. Logistic regression...
Hemorrhagic stroke is a major risk factor for cognitive impairment. Our study aimed to measure the effect of ginkgo biloba extract (EGB761) on ability and inflammatory expression in hemorrhagic model SD rats analyze their relationship. Forty were divided randomly into an group (normal control rats), SD+EGB761 supplemented with 45 mg/kg EGB761), CO (hemorrhagic using collagenase), CO+EGB761 EGB761) consisting 10 rats, respectively. The Y-electric maze test was selected function four groups....
While maximizing extent of resection (EOR) is associated with longer survival in lower-grade glioma (LGG) patients, the number cases remains insufficient determining a EOR threshold to elucidate clinical benefits, especially IDH-wild-type LGG patients.To identify effects on outcomes patients.IDH-wild-type patients were retrospectively reviewed. The effect and other predictor variables overall (OS) progression-free (PFS) was analyzed using Cox regression models Kaplan-Meier method.A total 94...
The Chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing (CMTM) family, comprising nine members, is involved in the tumorigenesis and progression of various cancers. However, expression profiles clinical significance CMTM family members hepatocellular carcinoma (HCC) are not fully clarified. In this study, RNA-sequencing data were downloaded from Cancer Genome Atlas (TCGA) databases. Kaplan-Meier method Cox proportional hazards regression analysis used to evaluate...
Lithium salt as a common drug in the clinical treatment of bipolar disorder, its application range is very wide. ions have many physiological functions, such improving hematopoietic function, regulating nervous system, heart antiviral, immune regulation, and neuroprotective effects. also has numerous pharmacological For example, it can be used an emotional stabilizer anti-inflammatory effects dermatology. It protective against various neurological diseases, leukopenia, hepatitis, pancreatic...
Abstract OBJECTIVES Given the increasing importance of patient’s perspective in adverse events reporting, Patient-Reported Outcomes version Common Terminology Criteria for Adverse Events (PRO-CTCAE™) has been proposed as new PRO measures oncology; however, its implementation not yet evaluated glioma patients, and standardized selection process priority symptom terms applied. METHODS A total 16 experts (13 neurosurgeons, 2 radiotherapists, 1 psychiatrist) from 14 medical centers China were...
Abstract Background Traumatic brain injury (TBI) secondary injury, especially white matter (WMI), is highly sensitive to neuroinflammation, which further leads unfavored long-term outcomes. Although the cross-talk between three active events, immune cell infiltration, BBB breakdown, and proinflammatory microglial/macrophage polarization, play a role in vicious cycle, its mechanisms are not fully understood. It has been reported that cordycepin, an extract from cordyceps militaris , can...