A5031672563- Gold and Silver Nanoparticles Synthesis and Applications
- Nanoplatforms for cancer theranostics
- Spectroscopy Techniques in Biomedical and Chemical Research
- Lanthanide and Transition Metal Complexes
- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Spectroscopy and Chemometric Analyses
- Radioactive element chemistry and processing
- Magnetism in coordination complexes
- Immune cells in cancer
- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- Glioma Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
Fudan University
2019-2025
State Key Laboratory of Medical Neurobiology
2022
Huashan Hospital
2021
Abstract Surgeons face challenges in intraoperatively defining margin of brain tumors due to its infiltrative nature. Extracellular acidosis caused by metabolic reprogramming cancer cells is a reliable marker for tumor regions. Although the acidic margin‐guided surgery shows promise improving surgical prognosis, clinical transition delayed having exogenous probes approved drug supervision authority. Here, an intelligent surface‐enhanced Raman scattering (SERS) navigation system delineating...
Glioma is the most frequent form of malignant brain tumors. Surgical debulking a major strategy for glioma treatment. However, there great challenge neurosurgeons to intraoperatively identify true margins because its infiltrative nature. Tumor residues or microscopic satellite foci left in resection bed are main reasons leading early recurrence as well poor prognosis. In this study, surface-enhanced resonance Raman scattering (SERRS) probe was developed guide resection. probe, molecular...
Intraoperative identification of the isocitrate dehydrogenase type 1 (IDH1) genotype, a key molecular marker in glioma, is essential for optimizing surgical strategies and tailoring post-surgical treatments. However, current clinical practices lack effective methods real-time IDH1 genotype detection during surgery. Here, novel strategy proposed intraoperative by simultaneously measuring two redox-related metabolites. A surface-enhanced Raman scattering (SERS) probe developed to detect...
Purpose Chemical exchange saturation transfer (CEST) MRI is versatile for measuring the dilute labile protons and microenvironment properties. However, use of insufficiently long RF duration (Ts) relaxation delay (Td) may underestimate CEST measurement. This study proposed a quasi‐steady‐state (QUASS) analysis robust quantification. Methods The signal evolution was modeled as function longitudinal rate during Td spin‐lock Ts, from which QUASS‐CEST effect derived. Numerical simulation in vivo...
The vast majority (>90%) of glioblastoma (GBM) patients belong to the isocitrate dehydrogenase 1 wild type (IDH1WT) group which exhibits a poor prognosis with median survival less than 15 months. This study demonstrated numerous immunosuppressive genes as well β-catenin gene, pivotal for Wnt/β-catenin signaling, were upregulated in 206 IDH1WT glioma using Chinese Glioma Genome Atlas (CGGA) database. increase microglia an phenotype and overexpression protein further verified GBM GL261...
Background Quantitative in‐situ pH mapping of gliomas is important for therapeutic interventions, given its significant association with tumor progression, invasion, and metastasis. Although chemical exchange saturation transfer (CEST) offers a noninvasive way imaging based on the pH‐dependent rate ( k sw ), reliable quantification in glioma remains constrained due to technical challenges. Purpose To quantify by measuring proton through optimized omega plot analysis. Study Type Prospective....