A5102832084- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Circular RNAs in diseases
- RNA Research and Splicing
- RNA modifications and cancer
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Radiomics and Machine Learning in Medical Imaging
- Advanced biosensing and bioanalysis techniques
- Glioma Diagnosis and Treatment
- COVID-19 diagnosis using AI
- T-cell and B-cell Immunology
- Pluripotent Stem Cells Research
- Plant Molecular Biology Research
- Cancer, Hypoxia, and Metabolism
- Nuclear Structure and Function
- Reproductive Physiology in Livestock
- Artificial Intelligence in Healthcare and Education
- Chromosomal and Genetic Variations
- Plant Stress Responses and Tolerance
- Intracerebral and Subarachnoid Hemorrhage Research
- Plant Reproductive Biology
- Advanced MRI Techniques and Applications
- FOXO transcription factor regulation
Zhejiang Lab
2023-2024
Fudan University
2020-2023
Shanghai Center for Brain Science and Brain-Inspired Technology
2021-2023
Shanghai Institute for Science of Science
2021-2023
Capital Medical University
2023
Cangzhou Central Hospital
2021
Shanghai University
2011-2020
Duke University
2019
Heilongjiang Bayi Agricultural University
2018
Jiangsu Center for Collaborative Innovation in Geographical Information Resource Development and Application
2015
MicroRNAs (miRNAs) are endogenously expressed small RNAs with a length of about 21 nt. MiRNAs silence their target genes at the post-transcriptional level. In plants, miRNAs play various developmental and physiological roles by cleavaging mRNAs predominantly. Drought high salinity most severe environmental abiotic stresses cause crop losses all over world.In this study, we identified miR-169g miR-169n (o) as salinity-responsive in rice. MiR-169n miR169o were miRNA cluster distance 3707 base...
microRNAs (miRNAs) are small noncoding RNAs that regulate cognate mRNAs at the post-transcriptional stage. Several studies have shown miRNAs modulate gene expression in mammalian cells by base pairing to complementary sites 3'-untranslated region (3'-UTR) of target mRNAs.In present study, miR-24 was found fas associated factor 1(FAF1) binding its amino acid coding sequence (CDS) region, thereby regulating apoptosis DU-145 cells. This result supports an augmented model whereby animal can...
Aberrant vascularization is a hallmark of cancer progression and treatment resistance. Here, we have shown that endothelial cell (EC) plasticity drives aberrant chemoresistance in glioblastoma multiforme (GBM). By utilizing human patient specimens, as well allograft genetic murine GBM models, revealed robust allows acquisition fibroblast transformation (also known mesenchymal transition [Endo-MT]), which characterized by EC expression markers, determined prominent population GBM-associated...
Abstract Tumor-initiating cells (TIC) are associated with tumor initiation, growth, metastasis, and recurrence. Aldehyde dehydrogenase 1A1 (ALDH1A1) is a TIC marker in many cancers, including breast cancer. However, the molecular mechanisms underlying ALDH1A1 functions solid tumors remain largely unknown. Here we demonstrate that enzymatic activity facilitates growth. Mechanistically, decreased intracellular pH cancer to promote phosphorylation of TAK1, activate NFκB signaling, increase...
Abstract Surgeons face challenges in intraoperatively defining margin of brain tumors due to its infiltrative nature. Extracellular acidosis caused by metabolic reprogramming cancer cells is a reliable marker for tumor regions. Although the acidic margin‐guided surgery shows promise improving surgical prognosis, clinical transition delayed having exogenous probes approved drug supervision authority. Here, an intelligent surface‐enhanced Raman scattering (SERS) navigation system delineating...
microRNAs (miRNAs) are small, non‑coding RNAs involved in multiple biological pathways by regulating post‑transcriptional gene expression. Previously, autophagy has been reported to suppress the progression of non‑small cell lung cancer (NSCLC). However, how miRNAs regulate NSCLC remains be elucidated. In present study, gene, autophagy‑related 2B (ATG2B), was identified as a novel target miR‑143. The overexpression miR‑143 able downregulate expression atg2b at transcriptional and...
Tanshinone is the liposoluble constituent of Salia miltiorrhiza, a root used in traditional herbal medicine which known to possess certain health benefits. Although it that tanshinones, including tanshinone I (T1), IIA (T2A), and cryptotanshinone (CT), can inhibit growth lung cancer cells vitro, mechanism under they act still unclear. AURKA, an oncogene, encodes serine-threonine kinase regulates mitotic processes mammalian cells. Here, we reported tanshinones mediate AURKA suppression partly...
MicroRNAs (MiRNAs) are small non-coding RNA molecules which act as important regulators of post-transcriptional gene expression by binding 3'-untranslated region (3'-UTR) target messenger (mRNA). In this study, we analyzed miRNA-34a (miR-34a) a tumor suppressor in non-small cell lung cancer (NSCLC) H1299 line. The level miR-34a four different NSCLC lines, H1299, A549, SPCA-1, and HCC827, was significantly lower than that the non-tumorigenic bronchial epithelium line BEAS-2B. human tissues,...
MicroRNAs play important roles in carcinogenesis and tumor progress. Lung cancer is the leading cause of mortality worldwide. In this study, function miR-181a-5p was investigated non-small-cell lung (NSCLC). Results showed that significantly decreased NSCLC tissues cell lines. The proliferation migration A549 cells transfected with mimic inhibited. Luciferase activity assay results demonstrated two binding sites Kras could be directly targeted by miR-181a-5p. Furthermore, down-regulated at...
Background: Quercetin has potential value in treating cardiovascular diseases, but it is not suitable for clinical application due to its own water solubility.The limitation of quercetin can be distinctly ameliorated by delivering with nanocarriers.Objective: To determine the effect quercetin-loaded mesoporous silica nanoparticles (Q-MSNs) on myocardial ischemia-reperfusion injury rats and mechanism.Methods: Q-MSNs were synthesized, morphology MSNs was characterized transmission electron...
MicroRNAs (miRNAs) are a type of small non-coding RNAs that regulate cognate mRNA expressions at the post-transcriptional stage. Although several miRNAs known to be involved in various biological processes, including developmental timing, patterning, embryogenesis, differentiation and organogenesis, growth control, apoptosis, many target genes functions most still unclear. Since there is only partial complementarity between their targets animal cells, it difficult identify specific for given...
MicroRNAs (miRNAs), which are a newly identified class of small single-stranded non-coding RNAs, regulate their target genes via post-transcriptional pathway. It has been proved that miRNAs play important roles in many biological processes. To better understand miRNA function on type 2 diabetes, we used an oligonucleotide microarray to monitor expression profiles Goto-Kakizaki (GK) and Wistar rats' skeletal muscle. was found seven were downexpressed two over-expressed the muscle GK rats....
In deep regression, capturing the relationship among continuous labels in feature space is a fundamental challenge that has attracted increasing interest. Addressing this issue can prevent models from converging to suboptimal solutions across various regression tasks, leading improved performance, especially for imbalanced and under limited sample sizes. However, existing approaches often rely on order-aware representation learning or distance-based weighting. paper, we hypothesize linear...
Glucocorticoid (GC) resistance in lymphoblastic malignancies is related to treatment failure and a marker of poor prognosis. Previous studies have suggested that microRNA-182 (miR-182) functions as an oncogene plays role tumorigenesis, through regulation FOXO3A. FOXO3A has been implicated tumor suppression GC-induced apoptosis, suggesting potential therapeutic target. Herein we investigated the miR-182 GC sensitivity malignancies. Expression was consistently higher human mouse GC-resistant...
Reprogrammed cells, including induced pluripotent stem cells (iPSCs) and nuclear transfer embryonic (NT-ESCs), are similar in many respects to natural (ESCs). However, previous studies have demonstrated that iPSCs retain a gene expression signature is unique from of ESCs, differences microRNA (miRNA) expression, while NT-ESCs more faithfully reprogrammed better developmental potential compared with iPSCs. We focused on miRNA explored the difference between ESCs especially NT-ESCs. also...
MicroRNAs (or miRNAs) are small non-coding RNAs (21-25 nucleotides) that involved in a wide range of activities related to the development and differentiation cells. Comparison miRNA expression profiles mouse P19 embryonic carcinoma cells with those differentiated neural stem showed level 65 miRNAs changed (2-fold) after differentiation. MiR-124a was dramatically upregulated (more than 20-fold) while miR-302 family miR-290-295 cluster were strongly down-regulated. Further analysis revealed...
MicroRNAs (miRNAs) constitute a critically important class of non-translated, small RNAs, which post-transcriptionally regulate gene expression via one the multiple mechanisms. To profile miRNA expression, microarrays have been extensively applied to high-throughput detection miRNAs. Here, we described novel 3'-end miRNA-labeling method for microarray by terminal-deoxynucleotidyl transferase (TdT). TdT can catalyze formation polynucleotides at RNA receptor molecule with deoxycytidine...
The respective value of clinical data and CT examinations in predicting COVID-19 progression is unclear, because the scans previously used are not synchronized time. To address this issue, we collected 119 patients with 341 longitudinal paired data, developed an AI system for prediction deterioration. By combining features extracted from our system, can predict whether a patient will develop severe symptoms during hospitalization. Complementary to show significant add-on values early stage...
MicroRNA (miRNA) microarray is a powerful tool to explore the expression profiling of miRNA.The current detection method used in miRNA mainly fluorescence based, which usually requires costly system such as laser confocal scanner tens thousands dollars.Recently, we developed low-cost yet sensitive for based on enzyme-linked assay.In this approach, biotinylated miRNAs were captured by corresponding oligonucleotide probes immobilized slide; and then would capture streptavidin-conjugated...
Plant small non-coding RNAs including microRNAs (miRNAs), interfering (siRNAs) and trans-acting siRNAs, play important roles in modulating gene expression cells. Here we isolated 21 novel endogenous RNA molecules, ranging from 18 to 24 nucleotides, Oryza sativa that can be mapped 111 hairpin precursors. Further analysis indicated most of these sequences originated putative miniature inverted-repeat transposable elements, a major type DNA transposon. Considering miRNA is characteristic...
MicroRNA (miRNA) microarrays have been successfully used for profiling miRNA expression in many physiological processes such as development, differentiation, oncogenesis, and other disease processes. Detecting by microarray is actually based on nucleic acid hybridization between target molecules their corresponding complementary probes. Due to the small size high degree of similarity among sequences, condition must be carefully optimized get specific reliable signals. Previously, we reported...