A5101565435- Retinal Development and Disorders
- RNA modifications and cancer
- MicroRNA in disease regulation
- Corneal Surgery and Treatments
- Extracellular vesicles in disease
- RNA Research and Splicing
- Venous Thromboembolism Diagnosis and Management
- Retinoids in leukemia and cellular processes
- Circular RNAs in diseases
- Electrolyte and hormonal disorders
- Cancer, Hypoxia, and Metabolism
- Cancer-related Molecular Pathways
- Cancer-related molecular mechanisms research
- Microtubule and mitosis dynamics
- Retinal Diseases and Treatments
- Neurological Disease Mechanisms and Treatments
- Epigenetics and DNA Methylation
- Endoplasmic Reticulum Stress and Disease
- Pulmonary Hypertension Research and Treatments
- Cardiac Ischemia and Reperfusion
- Biochemical effects in animals
- Acute Kidney Injury Research
- Bone Metabolism and Diseases
- Photochromic and Fluorescence Chemistry
- Neurogenesis and neuroplasticity mechanisms
Cangzhou Central Hospital
2020-2021
Anhui Medical University
2016-2020
Zhejiang Chinese Medical University
2014
Shanghai Ninth People's Hospital
2011-2014
King's College London
2014
Shanghai Jiao Tong University
2013
Dalian Medical University
2008
Recently, a cohort of miRNAs, including miR-31, was reported to be downregulated during osteogenic induction by miR microarray analysis. It remains unclear how changes in miR-31 expression collaborate with bone transcription factors activate the biological pathways that regulate differentiation mesenchymal stem cells (BMSCs). Here effects Runx2, and Satb2 on BMSCs were investigated using mimics inhibitors small interfering RNA for knockdown Runx2 plasmids overexpression Runx2. Our results...
Background: Quercetin has potential value in treating cardiovascular diseases, but it is not suitable for clinical application due to its own water solubility.The limitation of quercetin can be distinctly ameliorated by delivering with nanocarriers.Objective: To determine the effect quercetin-loaded mesoporous silica nanoparticles (Q-MSNs) on myocardial ischemia-reperfusion injury rats and mechanism.Methods: Q-MSNs were synthesized, morphology MSNs was characterized transmission electron...
As a reversible scar repair reaction, liver fibrosis can be blocked or even reversed by proper intervention during its formation. Our work suggests that acid-sensitive ion channel 1a (ASIC1a) participates in and presents novel mechanism involving m6 A modification miR-350/SPRY2. We demonstrated the expression of ASIC1a was significantly increased tissue patients with animal models fibrosis, as well PDGF-BB-induced activated HSC-T6. After downregulating ASIC1a, degree is reduced HSC...
Acid-sensing ion channel 1a (ASIC1a) allows Na+ and Ca2+ flow into cells. It is expressed during inflammation, in tumour ischaemic tissue, the central nervous system non-neuronal injury environments. Endoplasmic reticulum stress (ERS) caused by accumulation of misfolded proteins that interferes with intracellular calcium homoeostasis. Our recent reports showed ASIC1a ERS are involved liver fibrosis progression, particularly hepatic stellate cell (HSC) activation. In this study, we...
Recent research has demonstrated critical roles of a number microRNAs (miRNAs) in stem cell proliferation and differentiation. miRNA-9 (miR-9) is brain-enriched miRNA. Whether miR-9 role retinal progenitor (RPC) differentiation remains unknown. In this study, we show that plays an important RPC fate determination. The expression was inversely correlated with the nuclear receptor TLX, which essential regulator neural self-renewal. Overexpression downregulated TLX levels RPCs, leading to...
During retina development, retinal progenitor cell (RPC) proliferation and differentiation are regulated by complex inter- intracellular interactions. Bone marrow mesenchymal stem cells (BMSCs) reported to express a variety of cytokines neurotrophic factors, which have powerful trophic protective functions for neural tissue-derived cells. Here, we show that the expanded RPC cultures treated with BMSC-derived conditioned medium (CM) was substantially enriched bFGF CNTF, expressed clearly...
C23 is an abundant and multi-functional protein, which plays important role in various biological processes, including ribosome biogenesis maturation, cell cycle checkpoints transcriptional regulation [1, 2]. However, the of controlling tumorigenesis has not been well defined. Here we report that highly expressed cancer cells elevated expression facilitates proliferation vitro tumor xenograft growth vivo. Notably, binds to p53 through its GAR domain suppresses activity under DNA damage...
Abstract Background Pulmonary embolism (PE) is a primary clinical manifestation of venous thromboembolism (VTE). It has been demonstrated that pulmonary endothelial cells (PECs) are apoptotic-resistance in PE. In this study, PECs were collected from PE patients and mouse models. Western blot, RT-PCR, flow cytometry, H&E TUNEL assay, confocal TEM microscopy, luciferase reporter assay performed to determine the effects miR-28-3p on apoptosis if exosomes can act as shuttle transport PECs....
Abstract Background: Pulmonary arterial hypertension (PAH) is a devastating disease and long non-coding RNAs (lncRNAs) are essential for PAH progression. Also, lncRNA plasmacytoma variant translocation 1 (PVT1) plays important roles in cell proliferation migration, however, the effect of PVT1 on pulmonary artery smooth muscle cells (HPASMCs) remains unknown. This study aimed to determine role underlying mechanisms HPASMCs. Methods: The results demonstrated that expression was upregulated...