A5100438199- Retinal Development and Disorders
- Membrane Separation Technologies
- Corneal surgery and disorders
- MicroRNA in disease regulation
- Corneal Surgery and Treatments
- Intraocular Surgery and Lenses
- Membrane-based Ion Separation Techniques
- Ophthalmology and Visual Impairment Studies
- Extraction and Separation Processes
- Advanced biosensing and bioanalysis techniques
- Extracellular vesicles in disease
- Photochromic and Fluorescence Chemistry
- Carbon and Quantum Dots Applications
- Graphene research and applications
- Nanocluster Synthesis and Applications
- Flame retardant materials and properties
- Facial Rejuvenation and Surgery Techniques
- Textile materials and evaluations
- Collagen: Extraction and Characterization
- Soil, Finite Element Methods
- biodegradable polymer synthesis and properties
- Ocular Diseases and Behçet’s Syndrome
- MXene and MAX Phase Materials
- Circular RNAs in diseases
- Crystallization and Solubility Studies
Shanghai Jiao Tong University
2011-2025
Shanghai Ninth People's Hospital
2007-2025
Shanghai Institute of Hematology
2022-2025
Xidian University
2020-2023
Tianjin Academy of Fine Arts
2022
Cultural Relics Institute Hebei Province
2021
The Third Affiliated Hospital of Zhejiang Chinese Medical University
2019
Hebei University of Technology
2019
Southeast University
2017
Hefei University of Technology
2016
Abstract With the assistance of microwave irradiation, greenish‐yellow luminescent graphene quantum dots (gGQDs) with a yield (QY) up to 11.7% are successfully prepared via cleaving oxide (GO) under acid conditions. The and reduction processes accomplished simultaneously using treatment without additional reducing agent. When gGQDs further reduced NaBH 4 , bright blue (bGQDs) obtained QY as high 22.9%. Both GQDs show well‐known excitation‐dependent PL behavior, which could be ascribed...
Abstract Biocompatible polymer scaffolds are promising as potential carriers for the delivery of retinal progenitor cells (RPCs) in cell replacement therapy repair damaged or diseased retinas. The primary goal present study was to investigate effects blended electrospun nanofibrous membranes silk fibroin (SF) and poly(L-lactic acid-co-ε-caprolactone) (PLCL), a novel scaffold, on biological behaviour RPCs vitro . To assess cell-scaffold interaction, were cultured SF/PLCL indicated durations....
Abstract Retinal degenerative diseases, primarily owing to the gradual loss of neuronal cells, could lead blindness. Transplantation retinal progenitor cells (RPCs), which had unique ability differentiate into offered promising therapeutic potential for these diseases. However, a critical challenge in stem cell therapy was efficient promotion directed proliferation and differentiation cells. To overcome this limitation, we formulated zinc silicate bioceramic (ZS) composite hydrogel. The...
MicroRNAs manifest significant functions in brain neural stem cell (NSC) self-renewal and differentiation through the post-transcriptional regulation of neurogenesis genes. Let-7b is expressed mammalian regulates NSC proliferation by targeting nuclear receptor TLX, which an essential regulator self-renewal. Whether let-7b TLX act as important regulators retinal progenitor (RPC) remains unknown. Here, our data show that play roles controlling RPC fate determination vitro. suppresses...
Recent research has demonstrated critical roles of a number microRNAs (miRNAs) in stem cell proliferation and differentiation. miRNA-9 (miR-9) is brain-enriched miRNA. Whether miR-9 role retinal progenitor (RPC) differentiation remains unknown. In this study, we show that plays an important RPC fate determination. The expression was inversely correlated with the nuclear receptor TLX, which essential regulator neural self-renewal. Overexpression downregulated TLX levels RPCs, leading to...
Retinal degeneration is a main class of ocular diseases. So far, retinal progenitor cell (RPC) transplantation has been the most potential therapy for it, in which promoting RPCs neuronal differentiation remains an unmet challenge. To address this issue, innovatively designed L/d-phenylalanine based chiral nanofibers (LPG and DPG) are employed it finds that chirality fibers can efficiently regulate differentiation. qPCR, western blot, immunofluorescence analysis show right-handed helical DPG...
During retina development, retinal progenitor cell (RPC) proliferation and differentiation are regulated by complex inter- intracellular interactions. Bone marrow mesenchymal stem cells (BMSCs) reported to express a variety of cytokines neurotrophic factors, which have powerful trophic protective functions for neural tissue-derived cells. Here, we show that the expanded RPC cultures treated with BMSC-derived conditioned medium (CM) was substantially enriched bFGF CNTF, expressed clearly...
The aim of this study was to compare the visual performance Acrysof ReSTOR and Natural intraocular lenses (IOLs) following cataract surgery. A randomized prospective performed in which 64 eyes (51 patients) were divided randomly into two groups. Monofocal IOLs (Acrysof Natural) implanted 34 (27 multifocal ReSTOR) 30 (24 using phacoemulsification corrected distance acuity, near pseudoaccommodation, contrast sensitivity (CS) wavefront analysis measured at 1 week, month 3 months after vision...
In this study, polyphenols (LSP) were obtained from the fermentation broth of Lachnum singerianum. Two fractions isolated by Sephadex LH-20 chromatographic column, and primary fraction (LSP-1) was collected. The comprehensive physicochemical properties phenolic acids polyhydroxy compounds LSP-1 determined UV-visible spectroscopy, Fourier transform infrared gas chromatography-mass spectrometry. Results anticoagulant activity assay in vitro showed that could lengthen prothrombin time,...
With rapid development and application of nanotechnology, there is an increasing concern over the environmental fate, behavior, toxicity, exposure risk engineered nanomaterials (ENMS). In this review, we presented release pathways ENMS into environment their potential behavior with a focus on suspension aggregation interactions dissolved organic matter contaminants. addition, toxicity several types to various organisms was discussed. Then, concluded future research perspectives ENMS.
Retinal progenitor cell (RPC) transplantation has been proposed as a potential strategy for the treatment of retinal degeneration, which is leading cause vision loss. However, major obstacle poor proliferation RPCs. Accumulating evidence suggests that chiral features extracellular microenvironment are closely related to proliferation. Inspired by this, L/D-phenylalanine-derived molecules (LP and DP) employed construct biomimetic enhancing RPC LP DP self-assemble into left-handed right-handed...
To determine whether implantation of anaspheric intraocular lens (SN 60 WF Alcon) results in reduced spherical aberration and improved contrast sensitivity after cataract surgery.Randomized, prospective study. 260 patients/eyes were randomized to receive two types: Alcon Acrysof Natural (136 eyes) IQ (124 eyes). Quality vision was measured by visual acuity under mesopic photopic conditions. Ocular aberrations for 4.0- 6.0-mm pupil with Allegretto Wavelight Analyzer. All ophthalmologic...
As an emerging cutting-edge area, the anisotropic assembly of isotropic nanoparticles provides not only a unique but also convenient pathway for constructing materials with novel structures and functions. However, examples are still limited. In particular, methods that can delicately control preparation highly regular superstructures seldom reported. Here, we report that, in suspension block copolymer micelles, gradually depositing insoluble component to core–shell interface micelles...
MicroRNAs have a vital effect on the differentiation of many types progenitor cells. Recent studies suggested that miR-17 plays an important role in process brain neural cells (NPC). Nevertheless, its detailed functions regulating retinal (RPC) remain unclear. In our study, overexpression and knockdown were performed by transfecting RPC with mimics inhibitors, respectively. Next, we investigated proliferation following experiments: qPCR, CCK8, Edu staining, immunostaining Western blot. The...
Abstract Recently, asymmetrically functionalized two‐dimensional (2D) nanomaterials have attracted fevered interest as excellent candidates for building blocks of multifunctional and multidimensional systems due to the structural symmetry‐breaking. However, their preparation process typically involves high vacuum environment or specific equipment, obtained samples poor stability low yield. In this study, a facile approach has been developed achieve asymmetric deposition platinum...
Retinal progenitor cells (RPCs) transplantation has become a promising therapy for retinal degeneration, which is major kind of ocular diseases causing blindness. Since RPCs have limited proliferation and differentiation abilities toward neurons, it urgent to resolve these problems. MicroRNAs been reported vital effects on stem cell fate. In our study, the data showed that overexpression miR-381-3p repressed Hes1 expression, promoted differentiation, especially neuronal cells, inhibited...
Abstract In order to study the effect of curing temperature on shape memory properties (SMPs) GO‐CF hybrid‐reinforced SMPCs, eight sets composites were prepared at different temperatures (60, 70, 80, 90, 100, 110, 120, and 130°C). The rheological matrix, apparent density, porosity, microstructure, SMPs composite measured analyzed, respectively. results showed that 100°C, has highest density (1.52 g/cm 3 ), lowest porosity (0.47%), best SMPs, fixed rate 99.13%, recovery 96.54%, maximum force...