A5101580101- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Lymphoma Diagnosis and Treatment
- Nanoplatforms for cancer theranostics
- MicroRNA in disease regulation
- Retinal Development and Disorders
- Photochromic and Fluorescence Chemistry
- Sarcoma Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Corneal Surgery and Treatments
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Neuroscience and Neuropharmacology Research
- Supramolecular Self-Assembly in Materials
- Cancer, Stress, Anesthesia, and Immune Response
- Cardiac tumors and thrombi
- Hepatocellular Carcinoma Treatment and Prognosis
- Bone Tissue Engineering Materials
- Ion channel regulation and function
- Retinal Diseases and Treatments
- Retinal and Macular Surgery
- Medical Research and Treatments
- Traditional Chinese Medicine Analysis
- Gestational Diabetes Research and Management
- Advanced Radiotherapy Techniques
Shanghai Jiao Tong University
2015-2024
Shanghai First People's Hospital
2011-2024
Shanghai Institute of Hematology
2019-2022
XinHua Hospital
2022
Shanghai Children's Medical Center
2022
Shanghai Ninth People's Hospital
2019-2020
Wuxi Ninth People's Hospital
2019
Soochow University
2019
Harbin Medical University
2018
Shanghai Medical College of Fudan University
2017
Fabrication of self-healing injectable CS-Odex hydrogels <italic>via</italic> a dynamic Schiff-base linkage for RPC delivery.
Large-sized orbital bone defects have serious consequences that destroy integrity and result in maxillofacial deformities vision loss. The treatment of is currently palliative not reparative, suggesting an urgent demand for biomaterials regenerate bones. In this study, via alloying, extrusion surface modification, we developed mechanobiologically optimized magnesium (Mg) scaffolds (Ca–P-coated Mg–Zn–Gd scaffolds, referred to as Ca–P–Mg) the orthotopic reconstruction large-sized defects. At 6...
Tumor immunotherapy represents a highly promising modality for the treatment of triple-negative breast cancer (TNBC). Nevertheless, its therapeutic efficacy has been profoundly impacted by challenges such as low drug uptake, hypoxia, and immunosuppression. To address these problems, study develops strategy combining sonodynamic therapy (SDT) using biomimetic nanoparticles coated with hybrid membranes. The are loaded semiconducting polymers (PFODBT), Atovaquone (ATO), TMP195 to enhance...
Purpose: Polyethylenimine (PEI) has been widely used as a versatile template to develop multifunctional nanosystems for disease diagnosis and treatment. In this study, we manufactured iodine-131 (131I)-labeled PEI-entrapped gold nanoparticles (Au PENPs) novel nanoprobe single-photon emission computed tomography/computed tomography (SPECT/CT) imaging radionuclide therapy. Materials methods: PEI was PEGylated sequentially conjugated with Buthus martensii Karsch chlorotoxin (BmK CT,...
Retinal degeneration is a main class of ocular diseases. So far, retinal progenitor cell (RPC) transplantation has been the most potential therapy for it, in which promoting RPCs neuronal differentiation remains an unmet challenge. To address this issue, innovatively designed L/d-phenylalanine based chiral nanofibers (LPG and DPG) are employed it finds that chirality fibers can efficiently regulate differentiation. qPCR, western blot, immunofluorescence analysis show right-handed helical DPG...
We designed and synthesized 131I-labeled dendrimers modified with the LyP-1 peptide as a multifunctional platform for single-photon emission computed tomography (SPECT) imaging, radionuclide therapy, antimetastasis therapy of cancer. The was constructed by modifying amine-terminated generation 5 poly(amidoamine) 33.1 9.2 3-(4′-hydroxyphenyl)propionic acid-OSu (HPAO), followed acetylation remaining dendrimer terminal amines radiolabeling 131I via HPAO moieties. LyP-1-modified showed favorable...
Retinal photodamage is a high-risk factor for age-related macular degeneration (AMD), the leading cause of irreversible blindness worldwide. However, both pathogenesis and effective therapies retinal are still unclear debated.The anti-inflammatory effects thrombospondin-1 on blue light-induced inflammation in ARPE-19 cells were evaluated. Furthermore, anti-angiogenic human microvascular endothelial (hMEC-1 cells) laser-induced choroidal neovascularisation (CNV) mouse model vitro experiments,...
Compared with PET/CT or PET/MRI, SPECT/CT is cheaper and more readily accessible. This study was designed to investigate the efficacy of 99mTc-HYNIC-PSMA in detecting primary tumors metastases patients newly diagnosed prostate cancer (PCa).A retrospective analysis 31 pathologically proven PCa performed at Shanghai General Hospital from November 2020 2021. Planar whole-body imaging on all a scan PSMA-positive regions 3-4 h after intravenous injection 740 MBq 99mTc-HYNIC-PSMA. Positive PSMA...
Shenxian-shengmai (SXSM) oral liquid, a Chinese patent compound medicine, has been used to treat sinus bradyarrhythmias induced by mild sick syndrome in clinical practice. Myocardial ischemia, particular serious or right coronary-related heart diseases, can cause and cardiac dysfunction. Moreover, reperfusion of ischemic myocardium is associated with additional myocardial damage known as ischemia-reperfusion (I/R) injury. This study was designed evaluate the effects SXSM on dysfunction I/R...
Chlorotoxin (CTX) is an established blocker of small‑conductance Cl‑ channels and has previously been demonstrated to inhibit the invasion glioma cells. Buthus martensii Karsch chlorotoxin‑like toxin (BmK CT) first chlorotoxin-like peptide. The present study aimed determine inhibitory effect BmK CT on invasive ability cells, using a Transwell assay. was subsequently radiolabeled with radionuclide 125I its activity compared CT. Additionally, underlying anti‑invasive mechanism 125I‑BmK cells...
Retinal degenerations, which lead to irreversible decline in visual function, are still no effective recovery treatments. Currently, retinal progenitor cell (RPC) transplantation therapy is expected provide a new approach treat these diseases; however, the limited proliferation capacity and differentiation potential toward specific neurons of RPCs hinder their clinical applications. microRNAs have been reported serve as important regulators fate determination stem/progenitor cells. In this...
Retinal progenitor cell (RPC) transplantation has been proposed as a potential strategy for the treatment of retinal degeneration, which is leading cause vision loss. However, major obstacle poor proliferation RPCs. Accumulating evidence suggests that chiral features extracellular microenvironment are closely related to proliferation. Inspired by this, L/D-phenylalanine-derived molecules (LP and DP) employed construct biomimetic enhancing RPC LP DP self-assemble into left-handed right-handed...
MicroRNAs have a vital effect on the differentiation of many types progenitor cells. Recent studies suggested that miR-17 plays an important role in process brain neural cells (NPC). Nevertheless, its detailed functions regulating retinal (RPC) remain unclear. In our study, overexpression and knockdown were performed by transfecting RPC with mimics inhibitors, respectively. Next, we investigated proliferation following experiments: qPCR, CCK8, Edu staining, immunostaining Western blot. The...
Retinal progenitor cells (RPCs) transplantation has become a promising therapy for retinal degeneration, which is major kind of ocular diseases causing blindness. Since RPCs have limited proliferation and differentiation abilities toward neurons, it urgent to resolve these problems. MicroRNAs been reported vital effects on stem cell fate. In our study, the data showed that overexpression miR-381-3p repressed Hes1 expression, promoted differentiation, especially neuronal cells, inhibited...
This study aimed to identify the prognostic value of interim 18F-FDG PET/CT (I-PET) for germinal center B-cell-like (GCB) and non-GCB diffuse large B-cell lymphoma (DLBCL), respectively. Baseline (B-PET) I-PET scans were performed in 112 patients with DLBCL. The using Deauville five-point scale (D-5PS) criteria or percentage decrease SUVmax (∆SUVmax) GCB DLBCL evaluated. A significant difference progression-free survival (PFS) was found between (P < 0.05). Based on D-5PS criteria, divided...
Objective To construct the content of health education based on transcultural nursing in discharged patients who were acute myocardial infarction (AMI) and had different cultural backgrounds,and to instruct nurses choose formulate individual program prescription according patients' background.Methods Twenty experts worked tertiary A hospitals for 15 years,had secondary senior positions,were bachelor degree or above nursing,cardiovascular social science chosen received expert consultation...
Nuclear medicine imaging plays an important role in diagnosis,grading and prognosis of patients with gliomas.With the development nuclear medicine,a variety radiotracers have been proposed used as targets for glioma imaging.At present,the most widely SPECT are 201Tl,99Tcm-MIBI,123I-iodo-methyl tyrosine 131I-Buthus martensi Karsch chlorotoxin-like toxin.The PET include radiolabled glucose,amino acids,choline,nucleotides hypoxia markers.They can provide information substance metabolism,cell...