Immunotherapy is an attractive treatment strategy for cancer, while its efficiency and safety need to be improved. A dual-cascade activatable nanopotentiator sonodynamic therapy (SDT) chemodynamic (CDT)-cooperated immunotherapy of deep tumors via reshaping adenosine metabolism herein reported. This (NPMCA) constructed through crosslinking deaminase (ADA) with chlorin e6 (Ce6)-conjugated manganese dioxide (MnO2) nanoparticles a reactive oxygen species (ROS)-cleavable linker. In the tumor...

Inducing immunogenic cell death (ICD) by sonodynamic therapy (SDT) is promising for cancer immunotherapy, which however inefficient due to oxygen depletion that compromises SDT effect and mediates recruitment of immunosuppressive myeloid-derived suppressor cells (MDSCs). The fabrication sono-activatable semiconducting polymer nanopartners (SPNTi ) simultaneously augment ICD alleviate MDSCs immunotherapy reported. A polymer, hydrophobic hypoxia-responsive tirapazamine (TPZ)-conjugate,...

Immunotherapy has provided a promising modality for cancer treatment, while it often the issues of limited response rates and potential off-target side effects in clinical practice. We herein report construction semiconducting polymer pro-nanomodulators (SPpMs) with ultrasound (US)-mediated activatable pharmacological actions deep-tissue sono-immunotherapy orthotopic pancreatic cancer. Such SPpMs consist sonodynamic backbone grafted poly(ethylene glycol) chains linked two immunomodulators (a...

Abstract Sonodynamic therapy (SDT) has been explored for cancer therapy, especially deep tumors due to its low tissue penetration restriction. The therapeutic efficacy of SDT is limited the complicated tumor microenvironment. This study reports construction oxygen‐carrying semiconducting polymer nanoprodrugs (OSPN pro ) treatment via combining amplified with pyroptosis. An oxygen carrier perfluorohexane, sonodynamic as sonosensitizer, and reactive species (ROS)‐responsive prodrug are...

Abstract The high level of lactate in tumor microenvironment not only promotes development and metastasis, but also induces immune escape, which often leads to failures various therapy strategies. We here report a sono‐triggered cascade depletion strategy by using semiconducting polymer nanoreactors (SPN LCu ) for cancer cuproptosis‐immunotherapy. SPN mainly contain as sonosensitizer, oxidase (LOx) conjugated via reactive oxygen species (ROS)‐cleavable linker chelated Cu 2+ . Upon ultrasound...

This article reports a new approach for the synthesis of ultrasmall iron oxide nanoparticles (NPs) conjugated with Arg-Gly-Asp (RGD)-modified dendrimers (G5.NHAc-RGD-Fe3O4 NPs) as platform targeted magnetic resonance (MR) imaging C6 glioma cells. Ultrasmall Fe3O4 NPs synthesized via solvothermal route were RGD peptide-modified generation-5 poly(amidoamine) (G5.NH2-RGD). The final G5.NHAc-RGD-Fe3O4 formed following acetylation remaining dendrimer terminal amines. as-prepared multifunctional...

Regulation of stimulator interferon genes (STING) pathway using agonists can boost antitumor immunity for cancer treatment, while the rapid plasma clearance, limited membrane permeability, and inefficient cytosolic transport STING greatly compromise their therapeutic efficacy. In this study, we describe an extracellular matrix (ECM)-degrading nanoagonist (dNAc) with second near-infrared (NIR-II) light controlled activation intracellular mild photothermal-augmented chemodynamic-immunotherapy...

Chemodynamic therapy (CDT), as a powerful tumor therapeutic approach with low side effects and selective efficiency, has gained much attention. However, the intracellular content of H2O2 cellular bottleneck oxidative reaction rates at sites have limited antitumor efficacy CDT. Herein, series sulfur-deficient engineered biodegradable cobalt sulfide quantum dots (CoSx QDs) were constructed for improved synergistic photothermal- hyperthermal-enhanced CDT tumors through regulating photothermal...

Abstract Glioblastoma (GBM) is one of the deadliest primary brain tumors, but its diagnosis and curative therapy still remain a big challenge. Herein, neutrophil‐targeting semiconducting polymer nanotheranostics (SSPN iNO ) reported for second near‐infrared (NIR‐II) fluorescence imaging‐guided trimodal orthotopic glioblastoma in mouse models. The SSPN are formed based on two polymers acting as NIR‐II probe well photothermal conversion agent, respectively. A thermal‐responsive nitric oxide...

Cancer nanomedicine combined with immunotherapy has emerged as a promising strategy for the treatment of cancer. However, precise regulation activation antitumor immunity in targeting tissues safe and effective cancer remains challenging. Herein, we report tumor acidic microenvironment-responsive promodulator iron oxide nanoparticle (termed FGR) pH-activated action photothermal-enhanced chemodynamic FGR is formed via surface-modifying nanoparticles dextran-conjugated Toll-like receptor...

Abstract Due to the complicated tumor microenvironment that compromises efficacies of various therapies, effective treatment pancreatic cancer remains a big challenge. Sono‐activatable semiconducting polymer nanoreshapers (SPN DN H) are constructed multiply remodel orthotopic for potent immunotherapy. SPN H contain polymer, hydrogen sulfide (H 2 S) donor, and indoleamine 2,3‐dioxygenase (IDO) inhibitor (NLG919), which encapsulated by singlet oxygen ( 1 O )‐responsive shells with modification...

Abstract Bone metastasis is a type of metastatic tumors that involves the spreads malignant tumor cells into skeleton, and its diagnosis treatment remain big challenge due to unique microenvironment. We herein develop osteoclast cell dual‐targeting biomimetic semiconducting polymer nanocomposites (SPFeN OC ) for amplified theranostics bone metastasis. SPFeN contain iron oxide (Fe 3 O 4 nanoparticles inside core surface camouflaged hybrid membrane cancer osteoclasts. The camouflage enables...

Bone metastases are secondary malignant tumors that commonly occur after the spread of advanced cancer cells. We herein report activatable semiconducting polymer nanoinducers (ASPNFP) can amplify oxidative damage via sono-ferroptosis for bone metastasis treatment. ASPNFP constructed by encapsulating plasma amine oxidase-based nanoparticles (SPNP) and Fe3O4 into singlet oxygen (1O2)-responsive nanocarriers. generate 1O2 under ultrasound (US) irradiation a sonodynamic effect to destroy...

Abstract Proteolysis‐targeting chimeras (PROTACs) can provide promising opportunities for cancer treatment, while precise regulation of their activities remains challenging to achieve effective and safe therapeutic outcomes. A semiconducting polymer nanoPROTAC (SPN FeP ) is reported that ultrasound (US) tumor microenvironment dual‐programmable PROTAC activity deep‐tissue sonodynamic‐ferroptosis activatable immunotherapy. SPN formed through a nano‐precipitation sonodynamic polymer,...

Enzymes provide a class of potential options to treat cancer, while the precise regulation enzyme activities for effective and safe therapeutic actions has been poorly reported. Dual-enzyme decorated semiconducting polymer nanoagents second near-infrared (NIR-II) photoactivatable ferroptosis-immunotherapy are reported in this study. Such (termed SPHGA) consist hemoglobin (Hb)-based (SP@Hb), adenosine deaminase (ADA) glucose oxidase (GOx) with loadings thermal-responsive nanoparticle shell....

Infrared neural stimulation with the assistance of photothermal transducers holds great promise as a mini-invasive modulation modality. Optical nanoparticles absorption in near-infrared (NIR) window have emerged excellent due to their good biocompatibility, surface modifiability, and tunable optical absorption. However, poor activation efficiency limited depth are main predicaments encountered mediated by these nanoparticles. In this study, we prepared targeted polydopamine (PDA)-coated gold...