A5002498299- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Cancer Cells and Metastasis
- Mesenchymal stem cell research
- Extracellular vesicles in disease
- Polymer Surface Interaction Studies
- Dendrimers and Hyperbranched Polymers
- Advanced biosensing and bioanalysis techniques
- Photoacoustic and Ultrasonic Imaging
- Protein Degradation and Inhibitors
- Polydiacetylene-based materials and applications
- RNA Interference and Gene Delivery
- Wound Healing and Treatments
- Photodynamic Therapy Research Studies
- Epigenetics and DNA Methylation
- Corneal Surgery and Treatments
- Cancer, Hypoxia, and Metabolism
- Supramolecular Self-Assembly in Materials
- Graphene and Nanomaterials Applications
- Histone Deacetylase Inhibitors Research
- Circular RNAs in diseases
- Ocular Surface and Contact Lens
- Cancer Research and Treatments
- Advanced Nanomaterials in Catalysis
- Sulfur Compounds in Biology
Zhuhai People's Hospital
2021-2025
Jinan University
2021-2024
Hangzhou City University
2023
Zhejiang University
2018-2023
Affiliated Eye Hospital of Wenzhou Medical College
2019-2020
Wenzhou Medical University
2019-2020
City College of New York
2018
Abstract Epigenetic dysregulation is a common feature of myriad human diseases, particularly cancer. Defining the epigenetic defects associated with malignant tumors has become focus cancer research resulting in gradual elucidation cell regulation. In fact, most stages tumor progression, including tumorigenesis, promotion, and recurrence are accompanied by alterations, some which can be reversed drugs. The main objective therapy era personalized precision medicine to detect biomarkers...
Mesenchymal stem cells (MSCs) possess inherent tropism towards tumor cells, and so have attracted increased attention as targeted-therapy vehicles for glioma treatment.The objective of this study was to demonstrate the injection MSCs loaded with paclitaxel (Ptx)-encapsulated poly(d,l-lactide-co-glycolide) (PLGA) nanoparticles (NPs) orthotopic therapy in rats.Ptx-PLGA NP-loaded MSC obtained by incubating Ptx-PLGA NPs. The drug transfer cytotoxicity against were investigated transwell system....
Mesenchymal stem cell (MSC)-based biomimetic delivery has been actively explored for drug accumulation and penetration into tumors by taking advantage of the tumor-tropic properties MSCs. In this work, we further demonstrated feasibility MSC-mediated nano delivery, which was characterized "Trojan horse"-like transport via an endocytosis-exocytosis-endocytosis process between MSCs cancer cells. Chlorin e6 (Ce6)-conjugated polydopamine nanoparticles (PDA-Ce6) were developed loaded...
Enzymes provide a class of potential options to treat cancer, while the precise regulation enzyme activities for effective and safe therapeutic actions has been poorly reported. Dual-enzyme decorated semiconducting polymer nanoagents second near-infrared (NIR-II) photoactivatable ferroptosis-immunotherapy are reported in this study. Such (termed SPHGA) consist hemoglobin (Hb)-based (SP@Hb), adenosine deaminase (ADA) glucose oxidase (GOx) with loadings thermal-responsive nanoparticle shell....
Abstract The eradication of recalcitrant bacterial biofilm infections necessitates the development speedy diagnostics and prompt therapeutics. However, constructing a portable versatile platform that enables in situ monitoring accompanied by potent antibiofilm activity remains challenging. To address this conundrum, microneedle theranostic patch (Mn: C/G@MN) is devised incorporating an innovative biophotonic probe (manganese‐doped carbon dots, Mn: CDs) into methacrylated gelatin for visual...
The cutaneous wound in diabetic patients frequently encounters intractable pathogenic infections due to the hyperglycemia micromilieu which is conducive bacterial growth and multiplication. Despite extensive clinical use of antibiotics treat infections, emergence drug-resistant super pathogens as well potential side effects have elicited alarming challenges public health. To address this daunting concern, we devise develop a photo-activated cascade bio-heterojunctions (C-bio-HJs) for rapid...
Nanoscale drug delivery systems (nDDS) have been employed widely in enhancing the therapeutic efficacy of drugs against diseases with reduced side effects. Although several nDDS successfully approved for clinical use up to now, biological barriers between administration site and target hinder wider adoption disease treatment. Polyethylene glycol (PEG)-modification (or PEGylation) has regarded as gold standard stabilising complex environment. However, accelerated blood clearance (ABC)...
Phototherapy has great application prospects in superficial tumors, such as melanoma, esophageal cancer, and breast carcinoma, owing to the advantages of noninvasiveness, high spatiotemporal selectivity, less side effects. However, classical phototherapies including photodynamic photothermal therapy still need settle bottleneck problems poor efficacy, inevitable thermal damage, a rate postoperative recurrence. In this study, we developed nanocomposite with excellent optical properties...
A photomedicine consisting of a core for photothermal therapy, photosensitizer photodynamic and cancer-targeting moiety was fabricated to improve selectivity antitumor efficiency.Hyaluronic acid-decorated polydopamine nanoparticles with conjugated chlorin e6 (HA-PDA-Ce6) were synthesized characterized. Cell uptake, phototoxicity, penetration, distribution therapeutic effects evaluated.HA-PDA-Ce6 had high photoactivities therapy/photothermal therapy readily internalized via CD44-mediated...
To simplify the preparation of dendritic materials, host–guest molecular recognition and self‐assembly are utilized to form a supramolecular gene vector (DNCVP). DNCVP is constructed from an amino dendron‐conjugated naphthol, viologen containing pH‐sensitive hydrazone‐bond‐linked PEG, CB[8] with molar ratio 1:1:1. The pH‐ reducing‐sensitivity verified, stimuli‐responsive capacity enables tumor targeting delivery ability. Owing protection surface engineering endows low cytotoxicity good...