A5051025874- RNA Interference and Gene Delivery
- Analytical Methods in Pharmaceuticals
- Advanced biosensing and bioanalysis techniques
- Adipose Tissue and Metabolism
- Lung Cancer Research Studies
- Muscle Physiology and Disorders
- Drug Transport and Resistance Mechanisms
- Lung Cancer Treatments and Mutations
- Sustainable Supply Chain Management
- Pharmacogenetics and Drug Metabolism
- Helicobacter pylori-related gastroenterology studies
- Nanoparticle-Based Drug Delivery
- RNA modifications and cancer
- Innovation and Knowledge Management
- Receptor Mechanisms and Signaling
- Antibiotics Pharmacokinetics and Efficacy
- Diet and metabolism studies
- Metal-Organic Frameworks: Synthesis and Applications
- Nutrition and Health in Aging
- Maternal and fetal healthcare
- Myasthenia Gravis and Thymoma
- Cooperative Communication and Network Coding
- Gastrointestinal motility and disorders
- Exercise and Physiological Responses
- Virus-based gene therapy research
Tianjin Medical University Cancer Institute and Hospital
2015-2025
National Clinical Research Center for Digestive Diseases
2023-2025
Chongqing Medical University
2015-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2016-2024
Guangxi University
2024
Ningbo University
2024
Xihua University
2022-2023
Central University of Finance and Economics
2012-2023
Second Affiliated Hospital of Zhejiang University
2014-2023
Suizhou Central Hospital
2023
For designing a complex vector that has the advantages of both polyethylenimine (PEI) and chitosan for gene delivery, PEI/chitosan/DNA was constructed at various N/P ratios (the moles amine groups cationic polymers to those phosphate ones DNA) cytotoxicity transfection efficiency were evaluated. The results demonstrated chitosan/DNA binding degree depended on ratio. mean size between 100 nm 150 nm. Compared with PEI/DNA, (PEI/chitosan/DNA N/P=4, PEI/DNA N/P=10) appeared have low...
Angiogenesis plays an important role in tumor development and metastasis, many cancer cells upregulate VEGF expression to promote angiogenesis. Silencing by RNA interference is expected be a promising strategy suppress the growth. However, low transfection efficiency instability are main barriers for small interfering (siRNA) delivery. In this study, we developed polycation liposome-encapsulated calcium phosphate nanoparticles (PLCP) siRNA delivery vivo. silencing effect MCF-7 was...
Purpose This study is based on knowledge-based view to examine the relationships among buyer–supplier interaction, ambidextrous innovation and business performance. It includes competitive intensity dysfunctional competition clarify boundary conditions. Design/methodology/approach The ordinary least squares regression was conducted test hypotheses. survey data were collected from 182 Hong Kong manufacturing firms. Findings Buyer–supplier interaction facilitates innovation, namely...
Non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutation and concurrent mutations have a poor prognosis. This study aimed to examine anlotinib plus icotinib as first-line treatment option for advanced NSCLC carrying EGFR or without mutations.This phase 2, single-arm, multicenter trial (ClinicalTrials.gov NCT03736837) was performed at five hospitals in China from December 2018 November 2020. Non-squamous cases EGFR-sensitizing were treated icotinib....
Following the publication of above paper, and a corrigendum that has already been published (doi.org/10.3892/ijo.2023.5528) to attend errors were made in assembly Figs. 2 8, it was drawn Editor's attention by concerned reader two pairs data panels featuring overlapping existed comparing 1C 2D paper with Fig. journal Molecular Cancer Therapeutics, which before had submitted, even though this earlier did contain many same authors. Given further issue come light, owing number duplications...
Purpose As an effective mode to help small and medium enterprises (SMEs) raise working capital, supply chain finance has recently gained extensive attention. The purpose of this paper is explore the intrinsic mechanism how both weak strong ties in network impact financing performance (SCFP) SMEs from perspective network. Design/methodology/approach Based on extended resource-based perspective, proposes a theoretical model explain which influence SCFP through physical distribution flexibility...
This study aimed to assess the response prediction and prognostic values of different peripheral blood cell biomarkers for advanced lung adenocarcinoma (LUAD) patients receiving first-line therapy.Patients diagnosed with LUAD as well healthy controls benign pulmonary diseases were collected in this retrospective study. Propensity score matching (PSM) was performed a 1:1 ratio. Survival state estimated by Kaplan-Meier method Cox proportional hazard model used factors.Compared control groups,...
OBJECTIVE This prospective, randomized, controlled, head-to-head study was conducted to compare the efficacies of esomeprazole- and pantoprazole-based triple therapies for Helicobacter pylori eradication. METHODS From January 2002 October 2003, 200 H. pylori-infected patients were randomly assigned undergo twice daily treatment with esomeprazole 40 mg (n = 100) or pantoprazole combined clarithromycin 500 amoxicillin 1 g wk (ECA PCA groups, respectively). Follow-up endoscopy performed at 8...
A photomedicine consisting of a core for photothermal therapy, photosensitizer photodynamic and cancer-targeting moiety was fabricated to improve selectivity antitumor efficiency.Hyaluronic acid-decorated polydopamine nanoparticles with conjugated chlorin e6 (HA-PDA-Ce6) were synthesized characterized. Cell uptake, phototoxicity, penetration, distribution therapeutic effects evaluated.HA-PDA-Ce6 had high photoactivities therapy/photothermal therapy readily internalized via CD44-mediated...
Muscle atrophy and weakness are the adverse effects of long-term or high dose usage glucocorticoids. In present study, we explored fucoxanthin (10 μM) on dexamethasone μM)-induced in C2C12 myotubes investigated its underlying mechanisms. The diameter was observed under a light microscope, expression myosin heavy chain (MyHC), proteolysis-related, autophagy-related, apoptosis-related, mitochondria-related proteins analyzed by western blots immunoprecipitation. Fucoxanthin alleviates...
Abstract Synthetic nonionic surfactant vesicles (niosomes) are a colloidal system with closed bilayer structures, displaying distinct advantages in stability and cost compared liposomes. In this article, polysorbate cationic niosomes (PCNs) were developed as gene carriers. The PCNs comprised surfactants (i.e., polysorbates) cholesterol, synthesized using film hydration method. thus prepared possessed regular morphology, particle size of 100 ∼ 200 nm, zeta potential +30 45 mV. showed great...