A5101846124- Lung Cancer Treatments and Mutations
- Angiogenesis and VEGF in Cancer
- Lung Cancer Research Studies
- Catalytic C–H Functionalization Methods
- Cancer, Hypoxia, and Metabolism
- HER2/EGFR in Cancer Research
- Lung Cancer Diagnosis and Treatment
- Cancer Cells and Metastasis
- Chemical Synthesis and Analysis
- Cancer, Lipids, and Metabolism
- Immunotherapy and Immune Responses
- Peptidase Inhibition and Analysis
- Synthesis and Catalytic Reactions
- Colorectal Cancer Treatments and Studies
- Neuroendocrine Tumor Research Advances
- Estrogen and related hormone effects
- Cancer Treatment and Pharmacology
- Reproductive System and Pregnancy
- Multicomponent Synthesis of Heterocycles
- Cell Adhesion Molecules Research
- Cancer Risks and Factors
- Catalytic Cross-Coupling Reactions
- Quinazolinone synthesis and applications
- Gastric Cancer Management and Outcomes
- Cancer Mechanisms and Therapy
China Tobacco
2025
Royal Society of Chemistry
2024
Centre National pour la Recherche Scientifique et Technique (CNRST)
2024
Tianjin Medical University Cancer Institute and Hospital
2012-2024
Central China Normal University
2019-2022
Central People's Hospital of Zhanjiang
2022
Guangdong Medical College
2022
National Clinical Research
2014-2018
Tianjin Medical University
2008-2014
Memorial Hospital of South Bend
2012-2014
Autophagy attenuates the efficacy of conventional chemotherapy but its effects on immunotherapy have been little studied. Here, we report that renders tumor cells more susceptible to lysis by CTL in vivo. Moreover, bystander did not express antigen were killed CTL. This effect was mediated transient dramatic upregulation mannose-6-phosphate receptor (MPR) cell surface. Antitumor combined treatment related kinetics MPR and abrogation this event abolished chemotherapy. accumulation surface...
We report an I2/FeCl3-co-promoted formal [2 + 2+1] annulation of aryl methyl ketones, 2-aminobenzyl alcohols, and p-toluenesulfonylmethyl isocyanide (TosMIC) by neighboring group (-CH2OH) assistance. This is a novel example using the Van Leusen reagent as unique C1N1 "two-atom synthon" in synthesis imidazoles. Preliminary mechanism studies showed that TsCH2NH2 might be key intermediate this reaction. Furthermore, reaction not only unlocks strategy for imidazole synthesis, but also exploits...
Non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutation and concurrent mutations have a poor prognosis. This study aimed to examine anlotinib plus icotinib as first-line treatment option for advanced NSCLC carrying EGFR or without mutations.This phase 2, single-arm, multicenter trial (ClinicalTrials.gov NCT03736837) was performed at five hospitals in China from December 2018 November 2020. Non-squamous cases EGFR-sensitizing were treated icotinib....
The first synthesis of arylquinazolinones has been disclosed via the consecutive oxidative cyclization/ring-opening anilines and methyl ketones. This transformation is characterized by splitting ketone as acyl C1 sources through C(CO)–C(sp3) bond cleavage, using DMSO a source C–S which expands use ketones valuable building blocks enriches library preparation quinazolinones. Moreover, preliminary mechanistic studies indicate that this multicomponent reaction underwent sequence.
A novel and efficient multicomponent cyclization of methyl ketones, cyanamides, arylamines for the synthesizing 2,4-diamino-1,3,5-triazines via consecutive formation four C-N bonds is reported. This reaction characterized by employment two molecules cyanamide double C(sp3)-H amination avoiding complicated prepreparation substrates expanding substrate scope. Furthermore, this strategy provides a new approach generating diverse with broad scope under mild conditions.
A novel I2-mediated Povarov reaction of arylacetylenes and anilines for the synthesis 2,4-substituted quinolines has been developed, in which arylacetylene first acts as both a diene precursor dienophile. This work further develops to expand types precursors. Preliminary mechanistic studies indicate that I2/DMSO system realized oxidative carbonylation C(sp)–H then undergoes [4 + 2] cycloaddition reaction.
A novel multicomponent cascade cyclization and sulfenylation/selenation using aryl methyl ketones, isoquinolin-1-amine, sodium arylsulfinates/1,2-diphenyldiselane to synthesize imidazo[2,1-a]isoquinoline derivatives in one-pot via the construction of two C-N bonds one C-S/C-Se bond has been reported. This reaction realizes simultaneous C(sp3)-H amination sulfenylation/selenation, avoiding complicated prior substrate preparation. process simple operating conditions good compatibility.
A number of mutations in key oncogenes have been identified as important for the initiation and maintenance lung adenocarcinoma (LAC). This study elucidated prevalence prognostic significance epidermal growth factor receptor gene (EGFR) rearrangements anaplastic lymphoma kinase (ALK) patients with surgically resected primary LAC.We retrospectively analyzed 675 consecutive who underwent radical resection at a single institution. We concurrently EGFR Kirsten rat sarcoma viral oncogene homolog...
Our previous studies revealed that the level of activated circulating endothelial cells (aCECs) was correlated with progression-free survival (PFS) in antiangiogenesis therapy. Anlotinib displayed affirmatory efficacies several clinical trials non-small-cell lung cancer (NSCLC). To find a marker predicting efficacy anlotinib treatment, we investigated correlations aCECs PFS and overall (OS) patients NSCLC treated impact on human umbilical vascular (HUVECs). The blood samples 78 were...
The first synthesis of eight-membered N-containing heterocycles by oxidative bicyclization/ring extension arylacetylenes and aryl amines has been achieved. This protocol uses arylacetylene as an unusual two-carbon synthon incorporating the two parts cracked C[triple bond, length m-dash]C bond into final product, which provides a new method for using synthons further enriches cleavage methodology. Moreover, this multi-component reaction can provide diverse fused elegant N-heterocycles under...
We herein report an iodine-mediated formal [2 + 2 1] cyclization of methyl ketones, p-toluenesulfonyl hydrazines, and 1-aminopyridinium iodide for preparation 4-aryl-NH-1,2,3-triazoles under metal- azide-free conditions. Notably, this is achieved using hydrazines as azide surrogates, providing a novel route toNH-1,2,3-triazoles. Furthermore, approach provides rapid practical access to potent inhibitors indoleamine 2,3-dioxygenase (IDO).
A novel [2 + 1 3] cyclization reaction for the synthesis of 2-aryl-4-quinolinecarboxylates from aryl methyl ketones, arylamines, and 1,3-dicarbonyl compounds has been established. This metal-free process achieved C–C bond cleavage directly as a single-carbon synthon. The is highly efficient good substrate compatibility while operating under mild conditions. method practicability successfully realized bioactive molecules.
A novel and efficient formal [4 + 2+1] annulation of aryl methyl ketones 2-aminobenzyl alcohols for the synthesis benzo[e][1,4]diazepin-3-ones is reported. This reaction successfully affords diverse seven-membered ring lactams via dual C–O bond cleavage. preliminary mechanistic study showed that a multicomponent dicyclization ring-opening sequence might occur, with introduction sulfide proposed as last step. strategy mild conditions broad substrate scope has potential applications in...
A novel iodine promoted cyclization of enaminone with aryl methyl ketones has been developed as a straightforward method for constructing 2-hydroxy-pyrrol-3(2H)-ones. This strategy affords structurally diverse 2-hydroxy-pyrrol-3(2H)-ones rings in high yields. Moreover, quarternary alcohol constructed efficiently the reaction. Product purification required only washing CH2Cl2 solvent, thereby avoiding traditional chromatography and recrystallization, making this an example group-assisted chemistry.
A 47‐year‐old female with ALK‐rearranged lung adenocarcinoma developed leptomeningeal metastasis (LM) after progression on first‐line crizotinib. Alectinib 300 mg was commenced and the patient achieved clinical radiographic improvements. After nine months of alectinib mg, she started to experience symptomatic LM. Two concurrent non‐EML4‐ALK rearrangements, LOC388942‐ALK LINC00211‐ALK , were identified from CSF but not plasma samples. With primary lesions remaining stable, dose increased 600...
Abstract Background Antiangiogenesis plays a key role in the treatment of non‐small lung cancer ( NSCLC ). We observed cavitation lesions patients with stage IIIB/ IV treated E ndostar and vinorelbine‐cisplatin NP) chemotherapy, evaluated imaging characteristics clinical outcome who developed tumor cavitation. Methods Our study included 105 untreated received Endostar combination NP chemotherapy at T ianjin Lung Cancer Center. Chest computed tomography CT ) was performed to evaluate efficacy...
A novel method for the synthesis of 5H-benzo[a]fluoren-5-one from inactive nonterminal 1,6-alkynes through a free radical tandem bicyclization process has been established. This achieved continuous cyclization triggered rarely by α-position α,β-unsaturated ketones. The reaction constructed three C–C bonds in one step with readily accessible substrates and excellent substrate compatibility.
The presentation of neoantigens on the cell membrane is foundation for most cancer immunotherapies. Due to their extremely low abundance, analyzing in clinical samples technically difficult, hindering development neoantigen-based therapeutics more general use treatment diverse cancers worldwide. Here, we describe an integrated system, "Valid-NEO", which reveals patient-specific neoantigen therapeutic targets from minute amounts through direct observation, without computer-based prediction, a...
Inflammatory myofibroblastic tumor (IMT) is a rare originating from mesenchymal tissue. Epithelioid inflammatory sarcoma (EIMS) represents and particularly aggressive variant, associated with worse prognosis. Almost all EIMS cases exhibits activating anaplastic lymphoma kinase (ALK) gene rearrangements, which suggests that patients may potentially benefit treatment ALK tyrosine inhibitors (TKIs). We presented case involving 34-year-old woman who was diagnosed mediastinal had echinoderm...
// Qiongqiong Gao 1, 2, 3, 4 , Pupu Li Xiangli Jiang Zhongli Zhan 5 Qingna Yan Bo Zhang 6 and Chun Huang 1 Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, 300060, P.R. China 2 Key Laboratory of Prevention Therapy, 3 Tianjin's Department Thoracic Oncology, Pathology, Lung Center, Ultrasound Diagnosis, Second Hospital University, Correspondence to: Huang, email: yellowpure@126.com Keywords: anaplastic lymphoma kinase rearrangement, lung...