[reaction: see text] A novel and efficient carbon-carbon double-bond formation reaction via coupling of aryl or heteroaryl methyl ketones has been developed. dimethyl sulfoxide-iodine-CuO system was proven to be for this afforded the expected products in good yields. new synthetic strategy, a self-sorting tandem reaction, involved type presented first time.

2-(Methylthio)-1,4-diaryl-2-butene-1,4-dione (3) are prepared from readily available aryl methyl ketones in the presence of copper(II) oxide, iodine, and dimethyl sulfoxide. The success cross-coupling reaction 4-chloroacetophenone with 2-acetylthiophene confirms a proposed self-sorting tandem mechanism. Both Z- E-isomers compound 3 converted into corresponding 3-methylthio 2,5-diaryl furan 7 good yield through domino process involving reduction double bond followed by Paal−Knorr synthesis....

A simple and efficient synthesis of 11H-pyrido[2,1-b]quinazolin-11-ones by Cu(OAc)2·H2O-catalyzed reaction easily available substituted isatins 2-bromopyridine derivatives has been developed. The involves C–N/C–C bond cleavage two C–N formations in a one-pot operation. This methodology is complementary to previously reported synthetic procedures, plausible mechanisms are discussed.

An efficient synthesis of novel functionalized 2-aryl-4-(indol-3-yl)-4H-chromenes has been developed, in the presence a catalytic amount iodine, from easily available starting materials, 2-hydroxychalcone derivatives. Indole, substituted indoles and 7-azaindole are suitable for this transformation. The possible domino Michael addition–intramolecular cyclization reaction mechanism is proposed.

An unexpected C-C bond cleavage has been revealed in the absence of metal. This observation exploited to develop an efficient approach toward 3,6-diarylpyridazines and 6-arylpyridazin-3-ones from simple commercially available 1,3-dicarbonyl compounds methyl ketones.

A clean and efficient method for the domino synthesis of new functionalized benzofuro[2,3-c]pyridines from easily accessible 2-hydroxychalcones, α-bromo ketones ammonium acetate is described. Furan pyridine ring moieties are ingeniously formed in a one-pot operation this tricyclic system.

A highly efficient and stereoselective synthesis of coumarin-, 1,3-cyclohexanedione-, 1,4-naphthoquinone-fused 2,8-dioxabicyclo[3.3.1]nonanes is described. This was achieved via a sequential Michael addition/bicyclization reaction from easily accessible 3-(2-hydroxyphenyl)-1-phenylprop-2-en-1-one derivatives. Three chemical bonds (one C–C bond two C–O bonds), six-membered cycles, stereogenic centers were formed in one-pot operation.

A facile approach to 6-aryl/alkyl substituted 6H-indolo[2,3-b]quinolines from mono-N-substituted isoindigo derivatives in the presence of SnCl2·2H2O acid media is described. Pyrrole and pyridine rings are synchronously constructed one pot for these tetracyclic molecules. plausible reduction/hydrolysis/decarboxylation/cyclization/aromatization domino reaction mechanism proposed. Bis-N-substituted only gives corresponding reduction product, 3,3′-bioxindole.

A novel and efficient multicomponent cyclization of methyl ketones, cyanamides, arylamines for the synthesizing 2,4-diamino-1,3,5-triazines via consecutive formation four C-N bonds is reported. This reaction characterized by employment two molecules cyanamide double C(sp3)-H amination avoiding complicated prepreparation substrates expanding substrate scope. Furthermore, this strategy provides a new approach generating diverse with broad scope under mild conditions.

We report the X-ray crystal structure of 11 molecular clips and analyze influence substituents (e.g., OMe, Me, NO2) their location on observed packing. Molecular 3a 3b form tapelike structures in due to π−π interactions between aromatic walls. Compounds 3d, 3eC, 3fC dimers driven by critical C−H···O then tapes crystal. These two building motifs, interactions, can be used rationalize enantio- diastereoselectivity remaining five clips. For example, are found dictate formation homochiral...

A facile solvent- and catalyst-free method for the synthesis of a series new hydroxylated 2,4,6-trisubstituted pyridines under microwave irradiation was developed. The expected products were obtained through simplified purification process without protection hydroxyl group. UV-Vis fluorescence spectra these conjugated multi-hydroxyl compounds also investigated.

A highly efficient method for the construction of 3a,6a-dihydrofuro[2,3-b]furan derivatives has been developed via a novel bicyclization, which is very valuable synthesis fused furofuran compounds since it time-saving and catalyst-free. Based on coupled domino strategy to directly construct from methyl ketones.

A simple and efficient method for the synthesis of functionalized di-aromatic ring-fused 2,8-dioxabicyclo[3.3.1]nonane derivatives catalyzed by silver triflate from easily available 2-hydroxychalcones naphthols/substituted phenols is described. Two six-membered cycles were formed in a one-pot operation. This reaction was probably achieved via Friedel–Crafts alkylation/bicyclization domino process.

A simple and efficient method for one-pot selective synthesis of functionalized 2,8-oxazaxabicyclo[3.3.1]nonanes hydroxy-containing 5<italic>H</italic>-indeno[1,2-<italic>b</italic>]pyridin-5-ones under catalyst-free conditions has been developed.

Odourless and crystalline solid <italic>S</italic>-methylisothiourea sulfate can be used as the <italic>S</italic>-source for synthesis of aryl methyl sulfides.

An unprecedented I2/FeCl3-promoted cascade reaction of aryl methyl ketones with 8-aminoquinolines for the convenient synthesis (E)-3-(2-acyl-1H-benzo[d]imidazol-4-yl)acrylaldehydes was developed by merging annulation ring deconstruction. This novel strategy unlocked new reactivity and provided an attractive platform opening unactivated N-heteroaromatic compounds. Preliminary mechanistic investigation suggested that dual C(sp3)–H amination/C–N bond cleavage were key steps. Furthermore,...

A tert-butyl hydroperoxide-promoted oxidative annulation reaction of isatins with 2-(trimethylsilyl)aryl triflates for the convenient synthesis acridone derivatives has been established. Mechanistic investigation suggested that may proceed via consecutive Baeyer–Villiger-type rearrangement followed by an intermolecular cyclization. This synthetic approach offers several advantages, including broad substrate scope, good functional group tolerance, and simplicity operation. Additionally,...

Chiral molecular clips constitute a robust system for crystal engineering studies and undergo several levels of orthogonal organization including heterochiral dimerization, H-bond or metal−ligand mediated tape formation, longitudinal packing the tapes.