A highly efficient synthesis of hydantoins has been developed from simple and commercially available 1,3-dicarbonyl compounds, ureas, methyl ketones or terminal aryl alkenes. This protocol involves a sustainable integration two coupled domino processes: iodine-promoted unsymmetrical 1,4-enediones (domino I) the sequential transformation into II).

A novel one-pot reaction has been developed for the efficient synthesis of pyrrolo[2,1-a]isoquinolines and 1-dearyllamellarin core from (E)-(2-nitrovinyl)benzenes azomethine ylides generated in situ. This strategy provides a concise total lamellarin G trimethyl ether using electrophilic substitution palladium-catalyzed Suzuki-Miyaura cross-coupling reactions.

A molecular iodine-mediated formal [2+1+1+1] cycloaddition for the efficient synthesis of pyrrolo[2,1-<italic>a</italic>]isoquinolines from acetophenones, 1,2,3,4-tetrahydroisoquinoline (THIQ) and DMSO has been developed.

Presently, excessive carbon dioxide emissions represent a critical environmental challenge. Thus, urgent efforts are required to develop environmentally friendly and low-energy technologies for treatment. In this case, membrane separation technology stands out as promising avenue CO2 separation, with selective materials of high permeability playing pivotal role in process. Herein, we categorize membranes into three groups: inorganic membranes, organic emerging membranes. Moreover,...

A highly efficient and stereoselective synthesis of coumarin-, 1,3-cyclohexanedione-, 1,4-naphthoquinone-fused 2,8-dioxabicyclo[3.3.1]nonanes is described. This was achieved via a sequential Michael addition/bicyclization reaction from easily accessible 3-(2-hydroxyphenyl)-1-phenylprop-2-en-1-one derivatives. Three chemical bonds (one C–C bond two C–O bonds), six-membered cycles, stereogenic centers were formed in one-pot operation.

A trifluoroacetic acid (TFA)-mediated cascade oxidation/1,3-dipolar cycloaddition reaction of stabilized pyridinium salts with dimethyl sulfoxide (DMSO) has been developed in the presence K2S2O8 and trimethylethylenediamine (TMEDA). In this transition-metal-free reaction, DMSO acts as a one-carbon source, thus providing convenient method for efficient direct synthesis various indolizine derivatives.

Carbon dots (CDs) have attracted widespread attention in recent years due to their synthetic simplicity, biocompatibility, and unique photoluminescent behavior. In this work, water-soluble silicon–carbon (SiCDs) were synthesized, properties evaluated. First, a series of SiCDs was prepared by using novel magnetic hyperthermia method from citric acid (CA) 3-(2-aminoethylamino) propyldimethoxymethylsilane (AEAMPS). Then, based on the Stöber method, silica (SiO2) loaded onto one-pot reaction...

An acid-catalyzed multicomponent tandem cyclization protocol has been developed for the synthesis of polyfunctional dihydroindolizino[8,7-b]indoles from simple and readily available arylglyoxal monohydrates, tryptamines, trans-β-nitrostyrenes or malononitrile. This reaction represents a highly efficient convenient methodology diversely substituted heteropolycyclic scaffolds under mild, metal-free conditions.

A molecular iodine-mediated coupling cyclization reaction for the synthesis of 4-aryl-NH-1,2,3-triazoles has been developed from N-tosylhydrazones and sodium azide. This metal-free cascade [4 + 1] could rapidly synthesize valuable compounds via a sequential C-N N-N bond formation. Mechanistic studies demostrate that nitrogen atoms 1,2,3-triazoles are not entirely

A one-pot acid-mediated reaction has been developed for the N–H/α,β-C(sp3)–H trifunctionalization of pyrrolidine without any metallic reagents or external oxidants. This involves intermolecular [3 + 2] cycloaddition in situ-generated azomethine ylides with acrylic esters to provide facile access 2,3-dihydro-1H-pyrrolizine derivatives high yields under mild conditions.

A copper-catalyzed domino synthesis of 4H-pyrido[1,2-a]pyrimidin-4-ones has been developed from 1,4-enediones and 2-aminoheterocycles with air as the oxidant.

A highly efficient method for the construction of 3a,6a-dihydrofuro[2,3-b]furan derivatives has been developed via a novel bicyclization, which is very valuable synthesis fused furofuran compounds since it time-saving and catalyst-free. Based on coupled domino strategy to directly construct from methyl ketones.

A transition-metal-free multicomponent coupling cyclization reaction was explored involving arynes, tosylhydrazine, and α-bromo ketones. The proceeds via a formal [2 + 2 2] cycloaddition, giving access to cinnoline derivatives in moderate yields under mild conditions. Three chemical bonds were formed—two C–N one C–C bond—in single step.

A transition-metal-free multicomponent benzannulation reaction was developed from readily available ketones, nitro-olefins, and diester acetylenedicarboxylate. This approach provides a straightforward efficient way to construct polysubstituted benzene derivatives under mild conditions in high yields.

A multicomponent reaction has been developed for the synthesis of polyfunctional pyrazole derivatives from readily available arylglyoxal monohydrates, tosylhydrazine, and aldehydes or ketones. This synthetic method significant advantages in broad substrate scope, excellent regioselectivity, simple operation.

An efficient procedure has been developed for the preparation of tetrasubstituted unsymmetrical 1,4-enediones via copper-promoted autotandem catalysis and air as oxidant. Various N-nucleophiles are compatible with this reaction, such morpholine, piperidine, pyrrolidine, arylamines, pyrazole, imidazole, benzimidazole, benzotriazole. This reaction also significant advantages in easily available substrates, atom economy, bond-forming efficiency, environmental benignity.

Although 2-imino-1H-imidazol-5(2H)-ones have important biological activities in metabolism, their synthesis has rarely been investigated. Quinoxalines as "privileged scaffolds" medicinal chemistry extensively investigated, but the development of novel and efficient synthetic methods remains very attractive. Herein, we developed two copper-catalyzed domino reactions for quinoxalines involving CC bond-cleavage with a 1,3-dicarbonyl unit leaving group. The sequence includes aza-Michael...

An interesting σ-bond insertion/benzannulation reaction for the synthesis of polysubstituted naphthalene derivatives has been developed from readily accessible ketones, arynes, and alkynoates. This practical transition-metal-free method provides a novel route to diverse naphthalenes through substrate-controlled rearrangement with cleavage C-C bonds.

A transition-metal-free coupling annulation reaction of arynes, ketones, and alkynoates has been demonstrated. Using this formal [2 + 2 2] cycloaddition reaction, a wide variety naphthalene derivatives were conveniently constructed in one pot with high efficiency. In addition, novel valid successfully applied to the synthesis 1-phenanthrenol derivatives.

Abstract In this study, blue fluorescent polymer microspheres tracers are prepared by dispersion polymerization using aggregation induced emission monomers, styrene and sodium vinyl benzene sulfonate as raw materials. The properties of the investigated field scanning electron microscopy, fluorescence microscopy spectrum. results show that N ‐(4‐(4‐(1,2,2‐triphenylvinyl)phenoxy)butyl)acrylamide exhibits typical AIE in a mixture water tetrahydrofuran. smooth monodisperse....