A5100408884- Lung Cancer Research Studies
- CAR-T cell therapy research
- Inflammatory Biomarkers in Disease Prognosis
- Nanowire Synthesis and Applications
- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- Nanoplatforms for cancer theranostics
- Virus-based gene therapy research
- Immune Cell Function and Interaction
- Neuroendocrine Tumor Research Advances
- Cancer Treatment and Pharmacology
- Neuroblastoma Research and Treatments
- Lung Cancer Treatments and Mutations
- Image Processing and 3D Reconstruction
- Cancer Genomics and Diagnostics
- HIV Research and Treatment
- Dendrimers and Hyperbranched Polymers
- Nanoparticle-Based Drug Delivery
- Glioma Diagnosis and Treatment
- Cancer Cells and Metastasis
- Immunotherapy and Immune Responses
- Redox biology and oxidative stress
- Inflammatory Bowel Disease
- Spectroscopy Techniques in Biomedical and Chemical Research
- Cancer, Hypoxia, and Metabolism
Beijing Ditan Hospital
2021-2025
Capital Medical University
2021-2025
National Institute for Communicable Disease Control and Prevention
2022-2025
Nanjing Drum Tower Hospital
2020-2025
Third Affiliated Hospital of Harbin Medical University
2025
Nanjing University of Chinese Medicine
2025
Analytical Biosciences (China)
2025
Harbin Medical University
2025
Central South University
2025
Sun Yat-sen University
2019-2024
Adjuvant whole-breast radiotherapy is essential for breast cancer patients who adopted breast-conserving surgery (BCS) to reduce the risk of local recurrences, which however suffer from large-area and highly destructive ionizing radiation-induced adverse events. To tackle this issue, an afterglow/photothermal bifunctional polymeric nanoparticle (APPN) developed that utilizes nonionizing light precise afterglow imaging-guided post-BCS adjuvant second near-infrared (NIR-II) photothermal...
Non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutation and concurrent mutations have a poor prognosis. This study aimed to examine anlotinib plus icotinib as first-line treatment option for advanced NSCLC carrying EGFR or without mutations.This phase 2, single-arm, multicenter trial (ClinicalTrials.gov NCT03736837) was performed at five hospitals in China from December 2018 November 2020. Non-squamous cases EGFR-sensitizing were treated icotinib....
The aim of the present study was to investigate prognostic value combined platelet (PLT), fibrinogen (FBG), neutrophil lymphocyte ratio (NLR) and (PLR) (CO-NPF) for postoperative outcomes in patients with lung adenosquamous cancer (ASC). Test results from who presented at Cancer Institute Hospital Tianjin Medical University between January 2005 December 2013 were retrospectively reviewed. CO-NPF scored 0 4 according increased PLT, FBG, NLR PLR prior being split into two groups based on...
Circulating tumor cells (CTCs) have been exclusively studied and served to assess the clinical outcomes of treatments progression cancer. Most CTC data mainly derived from distinct cohorts or selected types. In present study, a total 594 blood samples 479 cases with 19 different carcinomas 30 healthy were collected analyzed by Subtraction enrichment method combined immunostaining-fluorescence in situ hybridization (iFISH). Non-hematopoietic aneuploid chromosome 8 (more than 2 copies)...
T-cell exhaustion was initially identified in chronic infection mice and subsequently described humans with cancer. Although the distinct signature of exhausted T (TEX) cells cancer has been well investigated, molecular mechanism is not fully understood. Using single-cell RNA sequencing, we report here that TEX esophageal are more heterogeneous than previously clarified. Sprouty RTK signaling antagonist 1 (SPRY1) notably enriched two subsets CD8+ cells. When overexpressed, SPRY1 impaired...
The development of multidrug resistance (MDR) during postoperative chemotherapy for colorectal cancer substantially reduces therapeutic efficacy. Nanostructured drug delivery systems (NDDSs) with modifiable chemical properties are considered promising candidates as therapies reversing MDR in cells. Selenium-doped manganese phosphate (Se-MnP) nanoparticles (NPs) that can reverse through sustained release selenium have the potential to improve effect cancer.Se-MnP NPs had an organic-inorganic...
High-reflectivity metallic films on aluminum substrates are crucial in advanced aerospace and military applications due to their excellent reflectivity workability. In order further improve the thermal stability of films, this study investigated deposition AgInCux (x = 1, 3, 5 wt.%) Al 6061 alloy using magnetron sputtering, exploring impact parameters composition optical properties stability. Increased copper content improved stability, while it compromised reflectivity. Additionally,...
Recent years have witnessed unprecedented strides in comprehending non-CD4 regulatory T cells (Tregs), such as CD8+ Tregs and double negative (DNT cells), their role sustaining immune tolerance restricting activation. This study investigates the of Foxp3+CD8+ during HIV infection assess markers associated with CD4+ Tregs. was designed a cross-sectional cohort study, comprising 21 age-matched healthy controls (HCs), 122 treatment-naïve participants (TNs), 60 people living (PLWH) receiving...
Abstract Chimeric antigen receptor (CAR)‐T cell therapy is a transformative treatment against advanced malignancies. Unfortunately, once administrated in vivo, CAR‐T cells become out of artificial control, and fierce response to may cause severe adverse events, represented by cytokine‐release syndrome on‐target/off‐tumor effects. Here, nanomodified switch strategy developed, leading sustained precise “on‐tumor only” activation cells. original gelatinase‐responsive nanoparticles (NPs) are...
Our previous studies revealed that the level of activated circulating endothelial cells (aCECs) was correlated with progression-free survival (PFS) in antiangiogenesis therapy. Anlotinib displayed affirmatory efficacies several clinical trials non-small-cell lung cancer (NSCLC). To find a marker predicting efficacy anlotinib treatment, we investigated correlations aCECs PFS and overall (OS) patients NSCLC treated impact on human umbilical vascular (HUVECs). The blood samples 78 were...
Taxane-induced peripheral neuropathy (TIPN) is a dose-limiting adverse effect. Ganglioside-monosialic acid (GM1) functions as neuroprotective factor. We assessed the effects of GM1 on prevention TIPN in breast cancer patients.We conducted randomized, double-blind, placebo-controlled trial including 206 patients with early-stage planning to receive taxane-based adjuvant chemotherapy follow-up more than 1 year. Subjects were randomly assigned (80 mg, day -1 2) or placebo. The primary endpoint...
Abstract Background Chimeric antigen receptor (CAR)-T cell therapy has demonstrated remarkable success in the treatment of hematologic malignancies, while not yet been replicated solid tumors. To some extent, disappointing results can be attributed to paucity and heterogeneity target antigens tumors since adequate are cornerstone for CAR-T cells recognize attack tumor cells. Methods We established a target-redirected universal (TRUE CAR-T) therapeutic modality, which exogenous loaded onto...
Abstract Therapeutic responses to chimeric antigen receptor (CAR) T cell therapy in patients with limited treatment options have been appealing several clinical trials. However, the efficacy of CAR‐T has challenged by obstacles when treating solid tumors, such as severe toxicities, restricted access tumor sites, suboptimal therapeutic persistence, and manufacturing issues. Nanotechnology advantages protecting cells from being suppressed microenvironment (TME) favorably adapting...
Background: In recent years, great improvement has been made in immunotherapies for non-small cell lung cancer (NSCLC). Current data have suggested that Programmed death ligand 1 (PD-L1) expression might not be an ideal marker patient selection isolation. Evidence increasing alternative markers, such as neutrophil-to-lymphocyte ratio (NLR), a biomarker of systemic inflammation response (SIR) previously associated with outcomes variety cancers including NSCLC, predictor and the to therapy. No...
Intraperitoneal chemotherapy (IPC) has been considered as an effective therapy for advanced gastric cancer (GC) especially those with peritoneal metastasis, while limited effectiveness, complications caused by chemotherapeutics and repeated infusion procedures restrict the application of IPC. In this study, to enhance efficacy safety IPC, we intended establish a biocompatible biodegradable nanocomplex composed intelligent gelatinase-responsive nanoparticles (NPs) thermosensitive gel, which...
The significance of androgen receptor (AR) in metastatic breast cancer (MBC) remains unclear, and it is still largely unknown how AR expression level influences HER2-positive tumors. This study aimed to investigate the prognostic predictive value HER2-enriched MBC. Primary and/or paired tumors 304 patients with pathologically confirmed MBC were collected immunohistochemically assessed for expression. associations other clinicopathological characteristics compared using Chi-square test....