A5091250034- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
- Cancer-related gene regulation
- Catalytic C–H Functionalization Methods
- RNA Interference and Gene Delivery
- Cancer-related Molecular Pathways
- Analytical chemistry methods development
- Advanced biosensing and bioanalysis techniques
- Photodynamic Therapy Research Studies
- Conducting polymers and applications
- Cancer, Hypoxia, and Metabolism
- Electrochemical Analysis and Applications
- Nanoparticle-Based Drug Delivery
- RNA modifications and cancer
- Cancer Research and Treatments
- Ubiquitin and proteasome pathways
- Cell death mechanisms and regulation
- Photoacoustic and Ultrasonic Imaging
- Mitochondrial Function and Pathology
- Advanced Sensor and Energy Harvesting Materials
- Mass Spectrometry Techniques and Applications
- Retinoids in leukemia and cellular processes
- Esophageal Cancer Research and Treatment
- Immunotherapy and Immune Responses
- Antimicrobial Peptides and Activities
National University of Singapore
2017-2025
Tianjin University
2017-2025
East China Normal University
2013-2025
Second Affiliated Hospital of Fujian Medical University
2025
Zhejiang Gongshang University
2025
Yangzhou University
2008-2025
Fujian Medical University
2024-2025
Guangzhou Medical University
2019-2024
Southwest University of Science and Technology
2022-2024
Nanjing University
2021-2024
Increased conversion of glucose to lactic acid associated with decreased mitochondrial respiration is a unique feature tumors first described by Otto Warburg in the 1920s. Recent evidence suggests that effect caused oncogenes and an underlying mechanism malignant transformation. Using novel approach measure cellular metabolic rates vitro, bioenergetic basis this increased glycolysis reduced was investigated two human cancer cell lines, H460 A549. The phenotype analyzed measuring respiration,...
The study of normal breast epithelial morphogenesis and carcinogenesis in vivo has largely used rodent models. Efforts at studying mammary cancer with xenotransplanted human cells have failed to recapitulate the full extent development seen breast. We developed an orthotopic xenograft model which both stromal components reconstructed gland are origin. Genetic modification before implantation ostensibly resulted outgrowth benign malignant lesions. This experimental allows for studies...
Live attenuated bacteria are of increasing importance in biotechnology and medicine the emerging field cancer immunotherapy. Oral DNA vaccination mediated by live often suffers from low infection efficiency due to various biological barriers during process. To this end, we herein report, for first time, a new strategy engineer cationic nanoparticle-coated bacterial vectors that can efficiently deliver oral vaccine efficacious By coating with synthetic nanoparticles self-assembled polymers...
We herein propose a bioengineering approach where bacterial outer membrane vesicles (OMVs) were coated on drug-loaded polymeric micelles to generate an innovative nanomedicine for effective cancer immunotherapy and metastasis prevention. Whereas OMVs could activate the host immune response immunotherapy, loaded drug within would exert both chemotherapeutic immunomodulatory roles sensitize cells cytotoxic T lymphocytes (CTLs) kill directly. demonstrated that systemic injection of such...
Pyroptosis as a lytic and inflammatory form of cell death is powerful tool to fight against cancer. However, pyroptosis usually activated by chemotherapeutic drugs, which limits its anti-tumor applications due drug resistance severe side effects. Herein, we demonstrate that membrane targeting photosensitizers can induce for cancer ablation with noninvasiveness low A series anchoring (TBD-R PSs) aggregation-induced emission (AIE) characteristics were prepared through conjugation TBD phenyl...
Traditional photosensitizers (PSs) show reduced singlet oxygen (1 O2 ) production and quenched fluorescence upon aggregation in aqueous media, which greatly affect their efficiency photodynamic therapy (PDT). Meanwhile, non-targeting PSs generally yield low antibacterial performance due to short lifetimes small effective working radii. Herein, a water-dispersible membrane anchor (TBD-anchor) PS with aggregation-induced emission is designed synthesized generate 1 on the bacterial membrane....
Abstract Mounting evidence suggests that gut microbiota can play an important role in pathophysiology of depression, but its specific molecular mechanisms are still unclear. This study was conducted to explore the associations between changes neurotransmitters and short-chain fatty acids (SCFAs) altered depressed mice. Here, chronic restraint stress (CRS) model depression built. The classical behavioral tests were assess depressive-like behaviors 16S rRNA gene sequence extracted from fecal...
Exogenous contrast-agent-assisted NIR-II optical-resolution photoacoustic microscopy imaging (ORPAMI) holds promise to decipher wide-field 3D biological structures with deep penetration, large signal-to-background ratio (SBR), and high maximum depth resolution ratio. Herein, conjugated polymer nanoparticle (CP NP) assisted ORPAMI is reported for pinpointing cerebral tumor vasculatures. The CP NPs exhibit a extinction coefficient of 48.1 L g-1 at the absorption 1161 nm, an ultrahigh PA...
Radiodynamic therapy (RDT), an emerging therapeutic approach for cancer treatment by employing ionizing irradiation to induce localized photodynamic (PDT) can overcome the drawbacks of limited penetration depth traditional PDT and unconcentrated energy in tumor radiotherapy (RT). Taking advantage aggregation-induced emission (AIE) photosensitizers with bright fluorescence efficient singlet oxygen production aggregate state, Hf-AIE coordination polymer nanoparticles (CPNs), which show both...
Organic room temperature phosphorescence (RTP) materials with ultralong lifetime possess the remarkable advantage in bioimaging for elimination of background noise by characteristic time scale. However, most RTP luminogens need to be excited harmful ultraviolet (UV) lamp, and exhibit green or yellow emission shallow tissue penetration, constraining vivo further application clinical diagnosis pathological study. In this text, much safer excitation process sunlight mobile phone flashlight is...
Abstract Sonodynamic therapy (SDT) holds growing promise in deep‐seated or large solid tumor treatment owing to its high tissue penetration depth ability; however, therapeutic efficacy is often compromised due the hypopermeable and hypoxic characteristics milieu. Herein, a semiconducting polymer nanoparticle (SPNC) that synergistically enhances alleviates hypoxia reported for sonodynamic of tumors. SPNC comprises core as converter coated with poly (ethylene glycol) corona. An...
Abstract X-ray-induced photodynamic therapy utilizes penetrating X-rays to activate reactive oxygen species in deep tissues for cancer treatment, which combines the advantages of and radiotherapy. Conventional usually requires heavy-metal-containing inorganic scintillators organic photosensitizers generate singlet oxygen. Here, we report a more convenient strategy based on class phosphorescence nanoscintillators, that act dual capacity as photosensitizers. The resulting low dose 0.4 Gy...
Abstract Immunotherapy, the most promising strategy of cancer treatment, has achieved outcomes, but its clinical efficacy in pancreatic is limited mainly due to complicated tumor immunosuppressive microenvironment. As a highly inflammatory form immunogenic cell death (ICD), pyroptosis provides great opportunity alleviate immunosuppression and promote systemic immune responses solid tumors. Herein, membrane‐targeted photosensitizer TBD‐3C with aggregation‐induced emission (AIE) feature...
Living materials based on bacterial cellulose (BC) represent a natural and promising candidate for wound dressing. Both physical adsorption chemical methods have been applied to BC realizing antibacterial function. However, effective long-lasting incorporation of bactericidal moieties remains challenging. Herein, Komagataeibacter sucrofermentans-based direct synthetic method fabricate photosensitizer-grafted through in situ metabolism the presence TPEPy-modified glucose is explored. The...
Abstract The low‐dimensional (LD) perovskites are proven to be capable of blocking moisture erosion and thereby improving the photovoltaic device stability. In this review, perovskite materials carefully summarized that induced by A‐position organic substituents, starting from crystal microstructure electronic structure LD (2D, 1D, 0D) with regulating dimensions, combined first principles calculation (DFT). By further studying thermodynamics dynamics crystallization nucleation growth LD–3D...
Glycolysis-dominant metabolic pathway in cancer cells can promote their therapeutic resistance against radiotherapy (RT). Carbon monoxide (CO) as a glycolysis inhibitor enhance the efficiency of RT. Herein, an X-ray responsive CO-releasing nanocomposite (HA@AuNC@CO) based on strong host-guest interactions between radiosensitizer and CO donor for enhanced RT is developed. The encapsulated gold nanoclusters (CD-AuNCs) effectively generate cytotoxic reactive oxygen species (ROS) under...
TGFβ1 treatment of B cell lymphomas decreases c-myc gene expression and induces apoptosis. Since we have demonstrated NF-κB/Rel factors play a key role in transcriptional control c-myc, explored the effects on WEHI 231 immature cells. A reduction activity followed treatment. In CH33 cells, observed an increase IκBα, specific inhibitor, due to induction. Engagement surface CD40 or ectopic c-Rel led maintenance c-Myc protection cells from TGFβ1-mediated Ectopic overrode apoptosis induced by...
Apoptosis-inducing factor (AIF) is a mitochondrial flavoprotein that triggers caspase-independent apoptosis. We describe here the cloning and characterization of novel AIF-homologous molecule designated AMID (AIF-homologous mitochondrion-associatedinducer death). lacks localization sequence but shares significant homology with AIF NADH oxidoreductases from bacteria to mammalian species. Immunofluorescent staining biochemical experiments indicated was co-localized mitochondria. Overexpression...
A series of beta-formyl-BODIPYs 2 were synthesized in high yields from tetramethyl-BODIPYs 1 via the Vilsmeier-Haack reaction and further functionalized using a Knoevenagel condensation to generate novel BODIPYs 3 4.