Glycolysis-dominant metabolic pathway in cancer cells can promote their therapeutic resistance against radiotherapy (RT). Carbon monoxide (CO) as a glycolysis inhibitor enhance the efficiency of RT. Herein, an X-ray responsive CO-releasing nanocomposite (HA@AuNC@CO) based on strong host-guest interactions between radiosensitizer and CO donor for enhanced RT is developed. The encapsulated gold nanoclusters (CD-AuNCs) effectively generate cytotoxic reactive oxygen species (ROS) under...

Epithelial‒mesenchymal transition (EMT) in retinal pigment epithelial (RPE) cells is believed to play a key role the pathogenesis of proliferative vitreoretinopathy (PVR). The ability Hirudo promote blood flow and dispel stasis may be related its anti-EMT effects. Through use network pharmacology method, mechanism by which treats PVR was investigated this study, findings were confirmed through vitro cellular tests. targets pathways active compounds against predicted via technique. ARPE-19...

As digital data undergo explosive growth, deoxyribonucleic acid (DNA) has emerged as a promising storage medium due to its high density, longevity, and ease of replication, offering vast potential in solutions. This study focuses on the protection retrieval during DNA process, developing technique that employs flow cytometry sorting (FCS) segregate multicolored fluorescent microparticles encoded with facilitating efficient random access. Moreover, encapsulated microparticles, formed through...

Abstract With the rapid growth of modern information data, DNA has emerged as a novel medium for data storage due to its durability, replicability, sustainability, and high density. This study focuses on compatibility, capacity, random access systems. A calcium phosphate (CaP) mineralized fluorescent SiO 2 (FSD@CaP) microspheres is developed by encapsulating fluorescence‐labeled encoding files onto surface that are intrinsically sized addressed two‐dimensional (2D) barcodes. The various...

Abstract For learners in distributed e‐learning environments, it is difficult, but very important, to locate the right peer for collaboration on knowledge, at time and way. This paper proposes use of context awareness (CA) support recommendation context. this purpose, explores that involves knowledge , social technical contexts . Accordingly, a three‐dimensional CA model includes potential proximity access By matching seeker candidate with respect these three dimensions, information...

Data with categorical attributes are ubiquitous in the real world. However, existing partitional clustering algorithms for data prone to fall into local optima. To address this issue, paper we propose a novel algorithm, ABC-K-Modes (Artificial Bee Colony based on K-Modes), traditional k-modes algorithm and artificial bee colony approach. In our approach, first introduce one-step procedure, then integrate procedure approach deal data. search process performed by scout bees, adopt multi-source...

Most of the initialization approaches are dedicated to partitional clustering algorithms which process categorical or numerical data only. However, in real-world applications, objects with both numeric and features ubiquitous. The coexistence attributes make methods designed for single-type inapplicable mixed-type data. Furthermore, best our knowledge, existing data, initial cluster centers determined randomly. In this paper, we propose a novel method mixed clustering. proposed method,...

The components with oral bioavailability ≥30% and drug similarity ≥0.18 were screened by the Traditional Chinese Medicine System Pharmacology Database Analysis Platform (TCMSP), effective grouping of Compound-Xueshuantong Capsule was obtained. At same time, targets each active component in obtained searching TCMSP. annotated UniProt database, disease treatment searched GeneCards database. target is intersected Wayne diagram drawn VennDiagram. ingredient intersection inputted into Cytoscape...

In the past years, during research on ubiquitous learning, we have completely or partially explored three kinds of e-learning systems, PC-based (ECLUE), PDA-based (CLUE+), and mobile phone-based (CLUE+1). Based these backgrounds, explore concept construction learning environment (ULE). ULE is established combinations between real world virtual space, personal space shared space. Learning in conducted interactions among essential communicative elements: social human, object world, artifact...

Effective knowledge management is promising to improve organizational and personal performance. It has been widely recognized that information communication technologies may contribute if they can be suitably utilized. This study discusses how social media support in terms of evolution, use/reuse sharing.

Personal knowledge management (PKM) is indispensable to human learning, working and living. Clouding computing, as an emerging impressive technology, promising support personal by providing users with all kinds of scalable services, such channels, tools, applications, social support, for users' amplification, use/reuse, sharing.

With the rapid development of economy, heavy metal pollution has brought serious harm to engineering construction in expansive soil area. The Experimental study are further reveal its physical and mechanical properties, better guide practice. effects ion concentration on compaction, permeability unconfined compressive strength soils were studied by preparing 3 different concentrations Pb2+ Zn2+ polluted Nanyang city Henan Province. results show that with increase concentration, maximum dry...

The impact of Ubiquitous Computing on Learning is not confined within technical dimension. Besides its facilitation, this new computing paradigm also challenges human’s belief learning, and compels us to rethink the design learning resources environments. paper explores concept Learning, proposes a conceptual framework for Environment (ULE) implementation. A ULE established combination between Real World Virtual Space, Personal Space Shared Space. in conducted interactions among three...

Photodynamic therapy (PDT) has the characteristics of being simple and non-invasive, with on-demand light control. However, most photosensitizers exhibit strong hydrophobicity, low quantum yields in water tumor selectivity. In this study, carbon network-hosted porphyrins (CPs) high biocompatibility efficient singlet oxygen (1O2) generation were developed to reduce biotoxicity avoid quenching caused by hydrophobic aggregation for enhanced PDT. The CPs prepared a solid-phase synthesis method...

Abstract Oxidative stress alters cellular microenvironment, facilitating cell apoptosis and inflammatory response, oxidation of lens constituents may ultimately result in cataracts. Astragaloside IV (AS‐IV) exhibits a variety pharmacological activities, such as antioxidative anti‐inflammatory activity via regulating various signaling pathways. However, the effect AS‐IV on epithelial cells its potential therapeutic role cataracts remained to be investigated. In this study, prevented H 2 O...

Computer-supported Ubiquitous Learning (CSUL) systems aim at providing ubiquitous learning resources and support for learners' needs, which makes it possible learners to promote active anytime, anyplace, with any device in way that prefer to. This paper addresses the design framework of a CSUL system, discusses interaction design, devices choice, context-awareness support, service CSUL.

Social interaction is critical to knowledge building and sharing in online learning. This paper identifies knowledge, social technical contexts as the three essential elements of context space for interaction, accordingly proposes a three-dimensional context-awareness (CA) model support including Awareness Knowledge Context, Technical Context. The activity context, mediator space, highlighted CA implementation. map employed visualise information. A case study (caLDT) provided test if helpful...

Context-awareness involved in e-learning includes awareness to knowledge context, social and technical context. This study proposes the use of context-awareness for personalized learning content recommendation environments, discusses key steps mechanism.

Abstract Introduction: Myopia is the most common cause of avoidable visual impairment worldwide, which causes huge economic burden and social burden. There are several ways to treat reduce myopia, but all have drawbacks; this reality drives us search for additional effective low-risk interventions treatment myopia. Acupuncture an ancient therapy with a history thousands years now widely used in medical system. Some randomized controlled trials reported that acupuncture, as adjuvant therapy,...