A5100347475- Cancer-related molecular mechanisms research
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Mycobacterium research and diagnosis
- Meta-analysis and systematic reviews
- Gastric Cancer Management and Outcomes
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- RNA modifications and cancer
- Clinical practice guidelines implementation
- Sarcoma Diagnosis and Treatment
- Medical Research and Treatments
- Traditional Chinese Medicine Studies
- Acupuncture Treatment Research Studies
- Circular RNAs in diseases
- Health Systems, Economic Evaluations, Quality of Life
- Gallbladder and Bile Duct Disorders
- Drug Transport and Resistance Mechanisms
- Ferroptosis and cancer prognosis
- Cerebrovascular and Carotid Artery Diseases
- MicroRNA in disease regulation
- Pediatric Hepatobiliary Diseases and Treatments
- RNA Research and Splicing
- Renal cell carcinoma treatment
- Nutrition and Health in Aging
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
Hong Kong Baptist University
2023-2024
Hangzhou DAC Biotech (China)
2024
Hebei General Hospital
2018-2024
Air Force Medical University
2023
Xijing Hospital
2021-2023
Chengdu University of Traditional Chinese Medicine
2022-2023
Hunan Normal University
2023
Sun Yat-sen University Cancer Center
2020-2023
State Key Laboratory of Oncology in South China
2020-2023
Comprehensive identification of somatic structural variations (SVs) and understanding their mutational mechanisms in cancer might contribute to biological differences help identify new therapeutic targets. Unfortunately, characterization complex SVs across the whole genome underlying esophageal squamous cell carcinoma (ESCC) is largely unclear. To define a comprehensive catalog SVs, affected target genes, ESCC, we re-analyzed whole-genome sequencing (WGS) data from 31 ESCCs using Meerkat...
Abstract Long noncoding RNAs (lncRNAs) have been reported to be involved in a variety of human diseases, including cancers. However, their mechanisms not yet fully elucidated. We investigated lncRNA changes that may associated with pancreatic cancer (PC) by analyzing published microarray data, and identified AGAP2-AS1 as relatively overexpressed PC tissues. qRT-PCR assays were performed examine expression levels AGAP2-AS1. MTT assays, colony formation EdU used determine the proliferative...
Tendon/ligament injuries are common sports injuries. Clinically, the repair of a ruptured tendon or ligament to its bony insertion is needed, but enthesis structure not well reestablished following surgical repair. Herein, we fabricated dual-layer aligned-random scaffold (ARS) by electrospinning and aimed investigate effect on tendon-to-bone healing in vivo.The random silk fbroin poly(L-lactic acid-co-e-caprolactone) (P(LLA-CL)) nanofibrous scaffolds were successfully methods. Ninety New...
4-Deoxybostrycin is a natural anthraquinone compound isolated from the Mangrove endophytic fungus Nigrospora sp. collected South China Sea. Nigrosporin deoxy-derivative of 4-deoxybostrycin. They were tested against mycobacteria, especially Mycobacterium tuberculosis. In Kirby-Bauer disk diffusion susceptibility test, they both had inhibition zone sizes over 25 mm. The results absolute concentration test suggested that inhibitory effects mycobacteria. Moreover, 4-deoxybostrycin exhibited good...
The aim of this study was to comprehensively analyze computed tomography features improve the diagnostic accuracy visceral pleural invasion peripheral non-small cell lung cancer.The 205 cancer patients were retrospectively studied. lesion's relation pleura classified into 5 grades. A multivariate logistic regression analysis conducted identify independent factors predicting invasion.The showed that sex (odds ratio [OR], 1.822; P = 0.080), indentation (OR, 4.111; < 0.001), tumor density...
Massage is a common therapy of nonpharmacological treatments, particularly in Tuina (Chinese massage) as its most style, detailed guidance reporting the intervention warranted for evaluation and replication. Based on CONSORT (Consolidated Standards Reporting Trials), we aimed to develop an Extension Tuina/Massage, namely "The STandards Interventions Clinical Trials Of Tuina/Massage (STRICTOTM)."A group professional clinicians, trialists, methodologists, developers guidelines,...
Surgery remains the first choice of cure for early stage lung cancer. However, many patients are diagnosed at advanced stage, and thus miss opportunity to undergo surgery. As such derive limited benefits from chemotherapy or radiotherapy, alternatives focusing on local control have emerged, including iodine‐125 seed implantation. The Interstitial Brachytherapy Society, Committee Minimally Invasive Therapy in Oncology, Chinese Anti‐Cancer Association organized a group multidisciplinary...
// Hui Li 1, * , Zhengran Jiang 2, 3, Qixin Leng 2 Fan Bai 1 Juan Wang 4 Xiaosong Ding Yuehong Xianghong Zhang 4, HongBin Fang 5 Harris G Yfantis 6 Lingxiao Xing and Feng Department of Pathology, Hebei Medical University, Shijiazhuang, Hebei, China the University Maryland School Medicine, Baltimore, Maryland, USA 3 The F. Edward Hébert Medicine at Uniformed Services Health Sciences, Bethesda, Second Hospital Biostatistics, Bioinformatics Biomathematics, Georgetown Center, Washington, D.C.,...
Long noncoding RNAs have been known to play key roles in myocardial ischemia/reperfusion injury. This study was conducted investigate whether upregulation of FGD5-AS1 can improve hypoxia/reoxygenation (H/R) injury cardiomyocytes and its underlying mechanisms. Pc-FGD5-AS1 used overexpress cardiomyocytes. Cholecystokinin octapeptide flow cytometry assays were performed detect the effect on cell H/R Quantitative real-time polymerase chain reaction luciferase reporter assay assess relationship...
Abstract Human rhinovirus (HRV) is a causative agent of acute respiratory tract infections. This study analyzed the prevalence and clinical characteristics three HRV groups (HRV‐A, ‐B, ‐C) among 1,165 children aged 14 years or younger who were hospitalized with lower infection in China. PCR reverse transcription‐PCR was performed to detect viruses nasopharyngeal aspirates collected from September 2007 August 2008 Changsha, detected 202 (17.3%) children; 25.3% HRV‐positive 13–36 months age (χ...
We studied the effects of glutamine-enriched nutritional support on intestinal mucosal barrier, matrix metalloproteinase (MMP)-2, MMP-9 and immune function during perioperative chemotherapy in patients with advanced gastric cancer. The study was conducted 94 cancer admitted from April 2015 to March 2016. They were randomly divided into observation control groups, n=47. Control group given basic whereas group. High-performance liquid chromatography used measure lactulose mannitol ratio urine...
Purpose: The goal of the current study was to identify potential prognostic biomarkers rhabdomyosarcoma (RMS). Materials and Methods: We screened chip sequencing datasets RMS through gene expression omnibus (GEO) database. A total 74 patient tissues 39 normal muscle cell were analyzed. Limma R software used differentially expressed genes (DEGs) between controls. GO plot package visualize results analysis. for pathaffy enrichment DEGs by Kyoto Encyclopedia Genes Genomes (KEGG). cutoff...
Background Identification of the high risk population for osteoporosis and timely prevention are best strategies at present. Detailed epidemiological investigation in a well-defined is necessary to explore population-based characteristics factors osteoporosis, thus facilitate better programs. Method In this prospective cross-sectional study, 1423 questionnaires were given out urban residents (female ≥ 40 years age, male ≥50 years) who lived 27 Elderly-Care Inns interspersed among seven...
Endometrial carcinoma (EC) is one of the common gynecological cancers with increasing incidence and revived mortality recently. Given heterogeneity tumors complexity lncRNAs, a panel lncRNA biomarkers might be more precise stable for prognosis. In present study, we developed new model to predict prognosis patients EC. EC-associated differentially expressed long noncoding RNAs (lncRNAs) were identified from The Cancer Genome Atlas (TCGA). Univariate COX regression least absolute shrinkage...
Portal vein thrombosis (PVT) and Budd-Chiari syndrome (BCS) are two rare vascular disorders of the liver that can lead to life-threatening complications. We conducted a global survey systematically analyze scientific publications in fields PVT BCS.All papers regarding BCS were identified via PubMed, EMBASE, Cochrane library databases. The publication year, country, type paper, study design, number citations summarized. Good quality defined as those which high proportion homogeneous patients...