A5011791983- Knee injuries and reconstruction techniques
- Bone Tissue Engineering Materials
- Silk-based biomaterials and applications
- Tendon Structure and Treatment
- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Polymer Surface Interaction Studies
- Orthopedic Infections and Treatments
- Osteoarthritis Treatment and Mechanisms
- Periodontal Regeneration and Treatments
- Radiopharmaceutical Chemistry and Applications
- Fuel Cells and Related Materials
- Adhesion, Friction, and Surface Interactions
- Shoulder Injury and Treatment
- Hip disorders and treatments
- Musculoskeletal synovial abnormalities and treatments
- Proteoglycans and glycosaminoglycans research
- Mesenchymal stem cell research
- Bone and Dental Protein Studies
- Cardiovascular Function and Risk Factors
- Orthopedic Surgery and Rehabilitation
- Cardiac Valve Diseases and Treatments
Washington University in St. Louis
2025
National University of Singapore
2021-2023
Huashan Hospital
2015-2020
Fudan University
2015-2020
State Council of the People's Republic of China
2018-2019
Tendon/ligament injuries are common sports injuries. Clinically, the repair of a ruptured tendon or ligament to its bony insertion is needed, but enthesis structure not well reestablished following surgical repair. Herein, we fabricated dual-layer aligned-random scaffold (ARS) by electrospinning and aimed investigate effect on tendon-to-bone healing in vivo.The random silk fbroin poly(L-lactic acid-co-e-caprolactone) (P(LLA-CL)) nanofibrous scaffolds were successfully methods. Ninety New...
The PCL/Gel-aligned scaffolds could enable to improve the regenerated tendon tissue with highly aligned cells and good mechanical strength in a rabbit patellar tendons injured model.
Chondroitin sulfate (CS), a glycosaminoglycan of native cartilage, has shown its potential in promoting chondrogenesis mesenchymal stem cells (MSCs), whereas the effect matrix stiffness CS-containing 3D environment on is still poorly understood. Herein, this study aimed at assessing CS concentration and hydrogels MSCs. Hydrogels composed 6% (w/v) gelatin methacryloyl (GelMA) three concentrations, i.e., 4%, 6%, or 10% (w/v), methacrylated chondroitin (CSMA) were prepared. The each composition...
Abstract Introduction: Hip femoroacetabular impingement (FAI) is a pre-arthritic hip disease and has an etiologic role in up to 50% of OA. Synovial macrophages fibroblasts have been reported play significant the pathophysiology synovitis Isolation these cells from synovial tissue obtained arthroscopy procedures not previously established. This study aims establish protocol harvest digest isolate fibroblasts, especially standardize procedure obtain synovium during total replacement (THR)....
Abstract Introduction: Femoroacetabular impingement (FAI) is the leading cause hip osteoarthritis (OA). PPARγ has been reported to have a protective effect on articular cartilage. Autophagy important for maintaining cellular homeostasis. We previously observed suppression of expression and dysregulation autophagy markers with progression human OA. This study aims investigate in cartilage tissue. Methods: Full-thickness explants were harvested from femoral neck zone patients FAI who underwent...
This study was designed to evaluate the biocompatibility and osseointegration of polyethylene terephthalate ligament after coating with hydroxyapatite (PET/HA) by using plasma spraying technique in vitro vivo.In this study, PET/HA sheets were prepared technique. The characterization, viability bone marrow stromal cells (BMSCs), mRNA expression formation-related genes evaluated vitro. vivo investigated rabbit anterior cruciate (ACL) reconstruction model micro-computed tomography (micro-CT)...
Ultra-high-molecular-weight polyethylene (UHMWPE) has been applied in orthopedics, as the materials of joint prosthesis, artificial ligaments, and sutures due to its advantages such high tensile strength, good wear resistance, chemical stability. However, postoperative osteolysis induced by UHMWPE particles poor bone-implant healing interface scarcity osseointegration is a significant problem should be solved imperatively. In order enhance affinity bone tissue, vascular endothelial growth...
Abstract Artificial ligaments utilized in reconstruction of anterior cruciate ligament ( ACL ) are usually made polyethylene terepthalate PET because its good mechanical properties vivo. However, it was found that the deficiencies hydrophilicity and biocompatibility hindered process ligamentization. Therefore, surface modification is deemed as a solution resolving such problem. Silk fibroin SF ), which characterized by low immunogenicity clinical applications, to prepare coating on + this...
A silk fibroin and hydroxyapatite segmented coating ligament is fabricated to enhances graft ligamentization osseointegration processes successfully.
Abstract The objective of this study was to evaluate the effect bone marrow stem cells (BMSCs)‐seeded polyethylene terephthalate (PET) scaffold for Achilles tendon repair in a rabbit model. allogeneic BMSCs were seeded onto PET and cultured vitro 14 days. Sixteen mature New Zealand rabbits underwent surgery establish 2‐cm defect BMSCs‐seeded implanted into one limb (BMSCs‐PET group), while without contralateral as control (PET group). All sacrificed at 6 12 weeks after surgery. At surgery,...
SF coating <italic>via</italic> EDC/NHS crosslink improved the osseointegration of PET ligaments within bone tunnel.
To evaluate the osteogenic capacity of tissue engineering bone<italic>in vivo</italic>and compare vascularization and osteogenesis between co- single-modified engineered bone.
The purpose of the present study is to modify polyethylene terephthalate ligament with hydroxyapatite via biomineralization and investigate its effect on graft-bone healing. After hydroxyapatite, surface characterization was examined by scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, water contact angle measurements. compatibility osteoinduction, along underlying signaling pathway involved hydroxyapatite-polyethylene ligament, were evaluated in...
Correction to: Radiographic Osteoarthritis Prevalence Over Ten Years After Anterior Cruciate Ligament ReconstructionInt J Sports Med 2019; 40(11): 683-695DOI: 10.1055/a-0902-8539
Abstract An enlarged bone tunnel may affect the graft–bone integration and pose a problem for revision anterior cruciate ligament (ACL) surgery. The purpose of this study was to evaluate effect remnant preservation on tibial enlargement in ACL reconstruction with polyethylene terephthalate (PET) artificial ligament. Twenty-four skeletally mature male beagles underwent PET both knees. One knee reconstructed using sleeve technique (remnant group), while contralateral without (control group)....
Periprosthetic osteolysis and aseptic loosening after total hip arthroplasty are the common causes for revision surgery, which initiated by wear particles released from articular surfaces of prosthetic components. These components include ultra-high molecular weight polyethylene, titanium alloy, Al2O3, ZrO2 polymethylmethacrylate. Wear activate macrophage via phagocytosis or pattern recognition receptor, resulting in release inflammatory mediators such as colony-stimulating factor (M-CSF),...