Elena Ivanova
A5072438750- interferon and immune responses
- Cytokine Signaling Pathways and Interactions
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Reproductive Biology and Fertility
- Lung Cancer Treatments and Mutations
- CAR-T cell therapy research
- Cancer Research and Treatments
- Lung Cancer Research Studies
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Cancer Mechanisms and Therapy
- Melanoma and MAPK Pathways
- Genetic Syndromes and Imprinting
- HER2/EGFR in Cancer Research
- Cancer-related molecular mechanisms research
- PI3K/AKT/mTOR signaling in cancer
- Peptidase Inhibition and Analysis
- Immune cells in cancer
- Neuroblastoma Research and Treatments
- Telomeres, Telomerase, and Senescence
- Monoclonal and Polyclonal Antibodies Research
- DNA Repair Mechanisms
Dana-Farber Cancer Institute
2015-2024
Ministry of Health
2024
BeiGene (China)
2019-2024
Babraham Institute
2011-2023
Barts Health NHS Trust
2023
St Bartholomew's Hospital
2023
Paul Ehrlich Institut
2023
Russian Academy of Sciences
2022
Institute of Cellular and Intracellular Symbiosis
2021
Massachusetts General Hospital
2003-2018
Whole-genome sequencing of 25 metastatic melanomas and matched germline DNA in humans reveals that the highest mutation load is associated with chronic sun exposure, PREX2 gene mutated approximately 14 per cent cases Melanoma a highly cancer, characterized by high lethality rapid development resistance to treatment. rate varies widely, exposure sunlight. — PTEN-interacting protein previously implicated breast cancer 14% cases. Although precise role melanoma remains be elucidated, ectopic...
Immune checkpoint blockade, exemplified by antibodies targeting the PD-1 receptor, can induce durable tumor regressions in some patients. To enhance efficacy of existing immunotherapies, we screened for small molecules capable increasing activity T cells suppressed PD-1. Here, show that short-term exposure to small-molecule inhibitors cyclin-dependent kinases 4 and 6 (CDK4/6) significantly enhances T-cell activation, contributing antitumor effects vivo, due part derepression NFAT family...
The Alternative Lengthening of Telomeres (ALT) pathway is a telomerase-independent for telomere maintenance that active in significant subset human cancers and vitro immortalized cell lines. ALT thought to involve templated extension telomeres through homologous recombination, but the genetic or epigenetic changes unleash are not known. Recently, mutations ATRX/DAXX chromatin remodeling complex histone H3.3 were found correlate with features pancreatic neuroendocrine cancers, pediatric...
Ex vivo systems that incorporate features of the tumor microenvironment and model dynamic response to immune checkpoint blockade (ICB) may facilitate efforts in precision immuno-oncology development effective combination therapies. Here, we demonstrate ability interrogate ex ICB using murine- patient-derived organotypic spheroids (MDOTS/PDOTS). MDOTS/PDOTS isolated from mouse human tumors retain autologous lymphoid myeloid cell populations respond short-term three-dimensional microfluidic...
Multiple myeloma (MM) evolves from a highly prevalent premalignant condition termed MGUS. The factors underlying the malignant transformation of MGUS are unknown. We report MGUS/MM phenotype in transgenic mice with Eμ-directed expression XBP-1 spliced isoform (XBP-1s), factor governing unfolded protein/ER stress response and plasma-cell development. Eμ-XBP-1s elicited elevated serum Ig skin alterations. With age, Eμ-xbp-1s transgenics develop features diagnostic human MM, including bone...
Abstract KRAS-driven lung cancers frequently inactivate TP53 and/or STK11/LKB1, defining tumor subclasses with emerging clinical relevance. Specifically, KRAS-LKB1 (KL)–mutant are particularly aggressive, lack PD-L1, and respond poorly to immune checkpoint blockade (ICB). The mechanistic basis for this impaired immunogenicity, despite the overall high mutational load of KRAS-mutant cancers, remains obscure. Here, we report that LKB1 loss results in marked silencing stimulator interferon...
Significance A significant proportion of head and neck cancer is driven by human papillomavirus (HPV) infection, the expression viral oncogenes involved in development these tumors. However, role HPV integration primary tumors beyond increasing oncoproteins not understood. Here, we describe how impacts host genome amplification disruption tumor suppressors as well driving inter- intrachromosomal rearrangements. Tumors that do have integrants display distinct gene profiles DNA methylation...
Abstract The clinical efficacy of epidermal growth factor receptor (EGFR) kinase inhibitors is limited by the development drug resistance. irreversible EGFR inhibitor WZ4002 effective against most common mechanism resistance mediated T790M mutation. Here, we show, in multiple complementary models, that to develops through aberrant activation extracellular signal-regulated (ERK) signaling caused either an amplification mitogen-activated protein 1 (MAPK1) or downregulation negative regulators...
Microfluidic culture has the potential to revolutionize cancer diagnosis and therapy.
Deep and durable responses with zanubrutinib plus obinutuzumab in patients R/R FL.
The 'expanded' HD CAG repeat that causes Huntington's disease (HD) encodes a polyglutamine tract in huntingtin, which first targets the death of medium-sized spiny striatal neurons. Mitochondrial energetics, related to N-methyl-d-aspartate (NMDA) Ca2+-signaling, has long been implicated this neuronal specificity, implying an integral role for huntingtin mitochondrial energy metabolism. As genetic test hypothesis, we have looked relationship between length repeat, expressed endogenous and ATP...
Pancreas ductal adenocarcinoma (PDAC) is a highly lethal cancer that typically presents as advanced, unresectable disease. This invasive tendency, coupled with intrinsic resistance to standard therapies and genome instability, are major contributors poor long-term survival. The genetic elements governing the propensity of PDAC have not been well elucidated. Here, in course validating resident genes recurrent focal amplifications PDAC, we identified Rio Kinase 3 (RIOK3) an amplified gene...
The number of children born since the origin Assisted Reproductive Technologies (ART) exceeds 5 million. majority seem healthy, but a higher frequency defects has been reported among ART-conceived infants, suggesting an epigenetic cost. We report first whole-genome DNA methylation datasets from single pig blastocysts showing differences between in vivo and vitro produced embryos. Blastocysts were either without (C-IVF) or presence natural reproductive fluids (Natur-IVF). Natur-IVF embryos...
BACKGROUND. Immune checkpoint blockade improves survival in a subset of patients with non-small-cell lung cancer (NSCLC), but robust biomarkers that predict response to PD-1 pathway inhibitors are lacking. Furthermore, our understanding the diversity NSCLC tumor immune microenvironment remains limited. METHODS. We performed comprehensive flow cytometric immunoprofiling on both and cells from 51 NSCLCs integrated this analysis clinical histopathologic characteristics, next-generation...