A5039744168- Cutaneous Melanoma Detection and Management
- Multiple Myeloma Research and Treatments
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- COVID-19 and healthcare impacts
- Cutaneous lymphoproliferative disorders research
- RNA modifications and cancer
- Telemedicine and Telehealth Implementation
- melanin and skin pigmentation
- HIV/AIDS drug development and treatment
- CAR-T cell therapy research
- Hair Growth and Disorders
- T-cell and B-cell Immunology
- Peptidase Inhibition and Analysis
- Dermatology and Skin Diseases
- Cancer-related gene regulation
- interferon and immune responses
- Digital Media and Visual Art
- Long-Term Effects of COVID-19
- Nonmelanoma Skin Cancer Studies
- Protein Kinase Regulation and GTPase Signaling
- Stress Responses and Cortisol
- Healthcare cost, quality, practices
- Pain Mechanisms and Treatments
Harvard University
2015-2023
Massachusetts General Hospital
2016-2023
Washington University in St. Louis
2010-2015
Pediatrics and Genetics
2014
Yale University
2012-2013
Abstract Objective We deployed a Remote Patient Monitoring (RPM) program to monitor patients with coronavirus disease 2019 (COVID-19) upon hospital discharge. describe the patient characteristics, and clinical outcomes of in our RPM program. Methods enrolled COVID-19 being discharged home from hospital. Enrolled had an app, were provided pulse oximeter thermometer. Patients self-reported symptoms, O2 saturation, temperature daily. Abnormal symptoms or vital signs flagged assessed by pool...
Although immune checkpoint inhibitors (ICIs), such as anti-programmed cell death protein-1 (PD-1), can deliver durable antitumor effects, most patients with cancer fail to respond. Recent studies suggest that ICI efficacy correlates a higher load of tumor-specific neoantigens and development vitiligo in melanoma. Here, we report low melanoma neoantigen burdens who responded had tumors expression pigmentation-related genes. Moreover, expansion peripheral blood CD8+ T populations specific for...
The histone methyltransferase WHSC1 (also known as MMSET) is overexpressed in multiple myeloma (MM) a result of the t(4;14) chromosomal translocation and broad variety other cancers by unclear mechanisms. Overexpression did not transform wild-type or tumor-prone primary hematopoietic cells. We found that ACA11, an orphan box H/ACA class small nucleolar RNA (snoRNA) encoded within intron WHSC1, was highly expressed t(4;14)-positive MM cancers. ACA11 localized to nucleoli bound what we believe...
Posters are crucial tools in public health for promoting information and advocating healthy behaviors. In China, posters play a pivotal role shaping perceptions attitudes towards COVID-19 vaccination by utilizing multimodal narratives. This paper emotionally with different demographic groups, including children, the elderly, families. The findings indicate that merging cultural values explores how poster designers synthesize textual visual elements to resonate text images, effectively foster...
Identification of cell type-specific enhancers is important for understanding the regulation programs controlling cellular development and differentiation. Enhancers are typically marked by co-transcriptional activator protein p300 or groups cell-expressed transcription factors. We hypothesized that a unique set regulates gene expression in human erythroid cells, highly specialized type evolved to provide adequate amounts oxygen throughout body. Using chromatin immunoprecipitation followed...
Addiction to UV light and opioids is increased by VitD deficiency, suggesting that a feedback loop promotes its synthesis.
In a Perspective, Mack Su and David Fisher discuss the development of immunotherapies for treatment melanoma other cancer types.
To the Editor: Teledermatology has provided vital dermatology care as COVID-19 pandemic forced ambulatory clinics to cease or limit in-person visits.1Perkins S. Cohen J.M. Nelson C.A. Bunick C.G. in era of COVID-19: experience an academic department dermatology.J Am Acad Dermatol. 2020; 83: e43-e44Abstract Full Text PDF PubMed Scopus (67) Google Scholar Despite rapid large-scale implementation teledermatology, optimal use telemedicine for specific dermatologic conditions remains...
In the red-haired background, altered pain thresholds exist and are explained by distinct OPRM1/MC4R signaling.
•Triple transgenic mice with the Rb1 deletion in germinal center B cells were generated.•Antigen-stimulated Rb1-deficient exhibited hyperproliferation and cell death.•Deletion of did not induce malignancy. The retinoblastoma gene (RB1) has been implicated as a tumor suppressor multiple myeloma (MM), yet its role remains unclear because majority cases 13q14 deletions, un-mutated RB1 expressed from retained allele. To explore MM, we examined functional consequences single- double-copy loss...
Activating mutations in Ras (N- and K-) are the most common point found patients with multiple myeloma (MM) associated poor clinical outcome. We sought to directly examine role of activation MM pathogenesis used two different tissue-specific Cre recombinase mouse lines (Cγ1-Cre AID-Cre), generate mice mutant Kras (KrasG12D) activated specifically germinal center B-cells. also generated KrasG12D allele a tumor-prone Arf-null genetic background. Surprisingly, we observed no significant...
There are currently seven coronaviruses that can infect humans and the latest addition to these viruses is severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Infection by SARS-CoV-2 known commonly as coronavirus disease 2019 (COVID-19). Aside from common manifestations of cough fever, neurologic symptoms such headache, disturbed consciousness, paresthesia, seizures have also been seen. By identifying incidence peripheral immune-mediated neuropathies (PIMN), early prevention be made.