A5017119785- Anesthesia and Neurotoxicity Research
- Mitochondrial Function and Pathology
- Radiation Therapy and Dosimetry
- Cell death mechanisms and regulation
- Intracerebral and Subarachnoid Hemorrhage Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Glioma Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Kruppel-like factors research
- Spinal Hematomas and Complications
- Photosynthetic Processes and Mechanisms
- RNA Interference and Gene Delivery
- Meningioma and schwannoma management
- Cancer Research and Treatments
- Cancer-related Molecular Pathways
- interferon and immune responses
- Peptidase Inhibition and Analysis
- Cervical and Thoracic Myelopathy
- Neurological Disease Mechanisms and Treatments
- Galectins and Cancer Biology
- FOXO transcription factor regulation
- Biochemical and Molecular Research
- Spine and Intervertebral Disc Pathology
- Tuberculosis Research and Epidemiology
- Cancer Genomics and Diagnostics
Massachusetts Department of Public Health
2024-2025
Center for Systems Biology
2022-2024
Harvard University
2019-2024
Dana-Farber Cancer Institute
2023
Wuhan University
2017-2021
Renmin Hospital of Wuhan University
2017-2021
Massachusetts General Hospital
2020-2021
Zaozhuang Municipal Hospital
2020
Zhongshan Hospital of Xiamen University
2012
Abstract Cristae membrane state plays a central role in regulating mitochondrial function and cellular metabolism. The protein Optic atrophy 1 (Opa1) is an important crista remodeler that exists as two forms the mitochondrion, membrane-anchored long form (l-Opa1) processed short (s-Opa1). mechanisms for how Opa1 influences cristae shape have remained unclear due to lack of native three-dimensional views cristae. We perform situ cryo-electron tomography cryo-focused ion beam milled mouse...
Abstract Glycine is a simple nonessential amino acid known to have neuroprotective properties. Treatment with glycine results in reduced infarct volume of the brain, neurologic function scores, and neuronal microglial death ischemic stroke injury. Neuroinflammation has been considered major contributor cerebral ischemia–induced brain damage. However, role neuroinflammation following unclear. The present study aimed determine whether involved effects ischemia Ischemic promotes M1...
Changes in lung ACE2 expression and apoptotic priming throughout life span may affect COVID severity.
Tumors significantly impact individuals' physical well-being and quality of life. With the ongoing advancements in optical technology, information robotic etc., laser technology is being increasingly utilized field tumor treatment, ablation (LA) tumors remains a prominent area research interest. This paper presents an overview recent progress LA therapy, with focus on mechanisms biological effects LA, commonly used lasers, image-guided robotic-assisted LA. Further insights future prospects...
Uterine serous cancer (USC) comprises around 10% of all uterine cancers. However, USC accounts for approximately 40% deaths, which is attributed to tumor aggressiveness and limited effective treatment. Galectin 3 (Gal3) has been implicated in promoting aggressive features some malignancies. Gal3's role pathology lacking.
Bisperoxovanadium (pyridine-2-carboxyl) [bpV(pic)] is a commercially available PTEN inhibitor. Previous studies from us and others have shown that bpV(pic) confers neuroprotection in cerebral ischemia injury. We set up to determine whether ERK 1/2 activation plays role bpV(pic)-induced neuroprotective effect found the phosphorylation levels of Akt (p-AKT) ERK1/2 (p-ERK 1/2) were down-regulated after ischemia–reperfusion The injection injury not only increased level p-AKT but also p-ERK 1/2....
Background:The introduction of magnetic resonance (MR)-guided radiation treatment planning has opened a new space for theranostic nanoparticles to reduce acute toxicity while improving local control.In this work, second-generation AGuIX ® (AGuIX-Bi) are synthesized and validated.AGuIX-Bi shown maintain MR positive contrast further amplifying the dose by replacement some Gd 3+ cations with higher Z Bi .These next-generation based on platform, which is currently being evaluated in multiple...
<title>Abstract</title> The increasingly fierce competition in the job market has brought unprecedented pressure and challenges to college students who are struggling find a job. In order address manual analysis insufficiency of mental state graduates job, this paper proposes method based on global local key fusion features, provide necessary intervention. Based rough set theory, importance employment sentiment-related words for is defined, information module constructed extract important...
Abstract The rarity of thymic epithelial tumors and absence targetable alterations present significant challenges for identifying improved systemic therapies. Recent advances in single-cell sequencing have enhanced our understanding normal thymus development the factors underlying malignant transformation. During medullary differentiation adulthood, anti-apoptotic are expressed, potentially increasing resistance to cell death thus facilitating tumorigenic processes. We hypothesized that this...
Background . Bone marrow-derived mesenchymal stem cells (BMSCs) have blossomed into an effective approach with great potential for the treatment of liver fibrosis. The aim this study was to investigate underlying antifibrosis mechanisms by which BMSC inhibit activated hepatic stellate (HSCs) in vivo and vitro. Methods To effect human bone (hBM-MSCs) on HSCs, we used HSCs coculture systems evaluate inhibition from aspects apoptosis HSCs. In addition, activation NADPH oxidase pathway changes...
Abstract Glioblastoma ( GBM ) is the most aggressive glioma in brain. Recurrence of almost inevitable within a short term after tumor resection. In retrospective study 386 cases collected between 2013 and 2016, we found that recurrence mainly occurs deep brain regions, including basal ganglia, thalamus, corpus callosum. But mechanism underlying this phenomenon not clear. Previous studies suggest neuroligin‐3 NLGN 3) necessary for growth. Our results show levels 3 cortex are higher than those...
Glioblastoma is the most common malignant tumor of brain.Despite advances in treatment, prognosis for condition has remained poor.Glioblastoma often associated with peritumoral brain edema (PTBE), which can result increased intracranial pressure and devastating neurological sequelae if left untreated.Surgery main treatment glioblastoma, however current international surgical guidelines do not specify whether glioblastoma-induced PTBE tissue should be resected.In this study, we analyzed...
Abstract Cristae membrane state plays a central role in regulating mitochondrial function and cellular metabolism. The protein Optic atrophy 1 (Opa1) is an important crista remodeler that exists as two forms the mitochondrion, membrane-anchored long form (l-Opa1) processed short (s-Opa1). mechanisms for how Opa1 influences cristae shape have remained unclear due to lack of native three-dimensional views cristae. We perform situ cryo-electron tomography cryo-focused ion beam milled mouse...
Abstract Although external beam radiotherapy (xRT) is commonly used to treat central nervous system (CNS) tumors in patients of all ages, young children treated with xRT frequently experience life-altering and dose-limiting neurocognitive impairment (NI) while adults do not. The lack understanding mechanisms responsible for these differences has impeded the development neuroprotective treatments. Using a newly developed mouse model xRT-induced NI, we found that function impaired by ionizing...
Although major organ toxicities frequently arise in patients treated with cytotoxic or targeted cancer therapies, the mechanisms that drive them are poorly understood. Here, we report vascular endothelial cells (ECs) more highly primed for apoptosis than parenchymal across many adult tissues. Consequently, ECs readily undergo response to commonly used anticancer agents including and drugs sensitive ionizing radiation BH3 mimetics vivo. Further, using differentiated isogenic human induced...