A5071452774- Bacteriophages and microbial interactions
- Photosynthetic Processes and Mechanisms
- Mitochondrial Function and Pathology
- Microbial infections and disease research
- ATP Synthase and ATPases Research
- Genomics and Phylogenetic Studies
- Vector-borne infectious diseases
- Plant Virus Research Studies
- Malaria Research and Control
- Wheat and Barley Genetics and Pathology
- Bacterial Genetics and Biotechnology
- Mycobacterium research and diagnosis
- Plant Disease Resistance and Genetics
- Mosquito-borne diseases and control
Boston VA Research Institute
2023-2024
Massachusetts General Hospital
2023-2024
Harvard University
2023-2024
Boston Children's Hospital
2024
University of Maryland, Baltimore County
2018-2022
Abstract Cristae membrane state plays a central role in regulating mitochondrial function and cellular metabolism. The protein Optic atrophy 1 (Opa1) is an important crista remodeler that exists as two forms the mitochondrion, membrane-anchored long form (l-Opa1) processed short (s-Opa1). mechanisms for how Opa1 influences cristae shape have remained unclear due to lack of native three-dimensional views cristae. We perform situ cryo-electron tomography cryo-focused ion beam milled mouse...
Abstract Cristae membrane state plays a central role in regulating mitochondrial function and cellular metabolism. The protein Optic atrophy 1 (Opa1) is an important crista remodeler that exists as two forms the mitochondrion, membrane-anchored long form (l-Opa1) processed short (s-Opa1). mechanisms for how Opa1 influences cristae shape have remained unclear due to lack of native three-dimensional views cristae. We perform situ cryo-electron tomography cryo-focused ion beam milled mouse...
Abstract Bacteriophages represent an enormous reservoir of novel genes, many which are unrelated to existing entries in public databases and cannot be assigned a predicted function. Characterization these genes can provide important insights into the intricacies phage–host interactions may offer new strategies manipulate bacterial growth behavior. Overexpression is useful tool study gene-mediated effects, we describe here construction plasmid-based overexpression library complete set for...
Asexual replication of Plasmodium falciparum occurs via schizogony, wherein 16–36 daughter cells are produced within the parasite during one semi-synchronized cytokinetic event. Schizogony requires a divergent contractile ring structure known as basal complex. Our lab has previously identified PfMyoJ (PF3D7_1229800) and PfSLACR (PF3D7_0214700) complex proteins recruited midway through segmentation. Using ultrastructure expansion microscopy, we localized both to novel subcompartment. While...
Bacteriophages Ilzat and Eleri are newly isolated Siphoviridae infecting Microbacterium foliorum NRRL B-24224. The phage genomes similar in length, G+C content, architecture share 62.9% nucleotide sequence identity.
Bacteriophage EmiRose is a siphovirus infecting Corynebacterium flavescens. The genome 37,431 bp long and composed of 47 protein-coding genes. Based on gene content similarity, not closely related to any previously sequenced bacteriophages in the actinobacteriophage database date, including other corynebacteriophages. classified as singleton.