A5101950331- Radiation Therapy and Dosimetry
- Nanoplatforms for cancer theranostics
- Advanced Radiotherapy Techniques
- Photoacoustic and Ultrasonic Imaging
- Advanced X-ray and CT Imaging
- Medical Imaging Techniques and Applications
- Nanoparticle-Based Drug Delivery
- Ultrasound and Hyperthermia Applications
- Radiation Dose and Imaging
- Radiation Detection and Scintillator Technologies
- Digital Radiography and Breast Imaging
- Boron Compounds in Chemistry
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Angiogenesis and VEGF in Cancer
- Radiomics and Machine Learning in Medical Imaging
- Optical Imaging and Spectroscopy Techniques
- MRI in cancer diagnosis
- Advances in Oncology and Radiotherapy
- Cancer Cells and Metastasis
- Electron and X-Ray Spectroscopy Techniques
- Molecular Biology Techniques and Applications
- Photodynamic Therapy Research Studies
- Radiation Effects and Dosimetry
Brigham and Women's Hospital
2016-2025
Harvard University
2015-2025
Dana-Farber Cancer Institute
2015-2025
Dana-Farber Brigham Cancer Center
2015-2025
Ashland (United States)
2019-2021
American Association of Physicists in Medicine
2018-2021
John Wiley & Sons (United States)
2018-2021
Duke Medical Center
2020-2021
Johns Hopkins University
2019-2021
Wake Forest University
2021
Brain metastasis impacts greatly on patients' quality of life and survival. The phase I NANO-RAD trial assessed the safety maximum tolerated dose systemic administration a novel gadolinium-based nanoparticle, AGuIX, in combination with whole brain radiotherapy patients multiple metastases not suitable for stereotactic radiotherapy.Patients measurable received escalating doses AGuIX nanoparticles (15, 30, 50, 75, or 100 mg/kg intravenously) day initiation WBRT (30 Gy 10 fractions) 5 cohorts 3...
More than 50% of all cancer patients receive radiation therapy. The clinical delivery curative dose is strictly restricted by the proximal healthy tissues. We propose a dual-targeting strategy using vessel-targeted-radiosensitizing gold nanoparticles and conformal-image guided therapy to specifically amplify damage in tumor neoendothelium. resulting vascular disruption substantially improved therapeutic outcome subsidized radiation/nanoparticle toxicity, extending its utility intransigent or...
from teaching and research institutions in France or abroad, public private centers.L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques niveau recherche, publiés ou non, émanant des établissements d'enseignement recherche français étrangers, laboratoires publics privés.
Selective killing of cancer cells while minimizing damage to healthy tissues is the goal clinical radiation therapy. This therapeutic ratio can be improved by image-guided delivery and selective radiosensitization cells. Here, we have designed tested a novel trimodal theranostic nanoparticle made bismuth gadolinium for on-site image contrast enhancement improve efficacy accuracy We demonstrate in vivo magnetic resonance (MR), computed tomography (CT) enhancement, tumor suppression with...
In this study, we quantify the relative damage enhancement due to presence of gold nanoparticles (GNP) in vitro a clinical 6 MV beam for various delivery parameters and depths. It is expected that depths modes produce larger proportions low-energy photons will have effect on cell samples containing GNP. HeLa cells with without 50 nm GNP were irradiated at 1.5, 5, 10, 15 20 cm. Conventional beams square aperture sizes 10 cm isocenter, flattening filter free (FFF) used. Relative DNA was...
AGuIX are gadolinium-based nanoparticles developed mainly for imaging due to their MR contrast properties. They also have a potential role in radiation therapy as radiosensitizer. We used MRI quantify the uptake of pancreatic cancer cells, and TEM intracellular localization. measured radiosensitization cell line low-energy (220 kVp) beam, standard 6 MV beam (STD) flattening filter free (FFF). demonstrated that presence significantly decreases survival when combined with an X-ray large...
Abstract Focused Ultrasound (FUS) has been shown to sensitize tumors outside the brain Radiotherapy (RT) through increased ceramide-mediated apoptosis. This study investigated effects of FUS + RT in healthy rodent brains and F98 gliomas. Tumors, or striata rats, were targeted with microbubble-mediated, pulsed (220 kHz, 102–444 kPa), followed by (4, 8, 15 Gy). (8, Gy) resulted ablative lesions, not observed only, tissue. Lesions visible using Magnetic Resonance Imaging (MRI) within 72 h...
AGuIX, a novel gadolinium-based nanoparticle, has been deployed in pioneering double-blinded Phase II clinical trial aiming to assess its efficacy enhancing radiotherapy for tumor treatment. This paper moves towards this goal by analyzing AGuIX uptake patterns 23 patients. A phantom was designed establish the relationship between concentration and longitudinal (
We report the design and fabrication of third generation ultrasmall PEGylated gold nanoparticles based platform (AuRad™) optimized for applications in radiation therapy. The AuRad™ nanoplatform has following key features: (I) surface coating hetero-bifunctional-PEG with amine, carboxyl, methoxy functional groups, which make this a versatile to conjugate various moieties like fluorophores, peptides, drugs, radiolabels; (II) size that is longer circulation, higher tumor uptake modulated...
Purpose: Although change in SUV measures and PET-based textural features during treatment have shown promise tumor response prediction, it is unclear which quantitative measure the most predictive. We compared relationship between pathologic overall survival with esophageal cancer. Methods: Fifty-four cancer patients received PET/CT scans before after chemo-radiotherapy. Of these, 45 underwent surgery were classified into complete, partial, non-responders to preoperative chemoradiation....
Beams-eye-view imaging applications such as real-time soft-tissue motion estimation are hindered by the inherently low image contrast of electronic portal devices (EPID) currently available for clinical use. We introduce and characterize a novel EPID design that provides substantially increased detective quantum efficiency (DQE), contrast-to-noise ratio (CNR) sensitivity without degradation in spatial resolution.
Tumor vascular disrupting agents (VDAs) represent a promising approach to the treatment of cancer, in view tumor vasculature's pivotal role survival, growth and metastasis. VDAs targeting tumor's dysmorphic endothelial cells can cause selective rapid occlusion vasculature, leading cell death from ischemia extensive hemorrhagic necrosis. In this study, potential for applying gold nanoparticles (AuNPs) as VDAs, during brachytherapy, is examined. Analytic calculations based on electron energy...
Purpose: Theoretical microdosimetry at the subcellular level is employed in this study to estimate dose enhancement tumor endothelial cell nuclei, caused by radiation-induced photo/Auger electrons originating from gold nanoparticles (AuNPs) targeting endothelium, during brachytherapy. Methods: A vascular (EC) modeled as a slab of 2 μm (thickness) × 10 (length) (width). The EC contains nucleus 5 diameter and thickness 0.5–1 μm, corresponding size 5%–10% cellular volume, respectively. Analytic...
Background:The introduction of magnetic resonance (MR)-guided radiation treatment planning has opened a new space for theranostic nanoparticles to reduce acute toxicity while improving local control.In this work, second-generation AGuIX ® (AGuIX-Bi) are synthesized and validated.AGuIX-Bi shown maintain MR positive contrast further amplifying the dose by replacement some Gd 3+ cations with higher Z Bi .These next-generation based on platform, which is currently being evaluated in multiple...
Purpose: The aim of this study is to quantify and compare the dose enhancement factor from gold nanoparticles (AuNP) tumor endothelial cells for different concentrations AuNP, clinical MV beam configurations. Methods: Tumor are modeled as slabs measuring 10 × 2 μ m. A spherical AuNP simulated on surface cell, within blood vessel. 6 photon beams with without flattening filter investigated field sizes, depths in material modulation. incident energy spectra each configuration generated using...