A5005494837- Radioactive element chemistry and processing
- Analytical chemistry methods development
- Mass Spectrometry Techniques and Applications
- Trace Elements in Health
- Electrochemical Analysis and Applications
- Microfluidic and Capillary Electrophoresis Applications
- X-ray Diffraction in Crystallography
- Mesoporous Materials and Catalysis
- Crystallization and Solubility Studies
- Nanoparticle-Based Drug Delivery
- Radioactivity and Radon Measurements
- Catalytic Processes in Materials Science
- Nanoplatforms for cancer theranostics
- Advanced X-ray and CT Imaging
- Analytical Chemistry and Chromatography
- Alzheimer's disease research and treatments
- Polymer Surface Interaction Studies
- Coagulation and Flocculation Studies
- Monoclonal and Polyclonal Antibodies Research
- Electrocatalysts for Energy Conversion
- Inhalation and Respiratory Drug Delivery
- Plant Micronutrient Interactions and Effects
- Radiation Dose and Imaging
- Bone and Dental Protein Studies
- Microfluidic and Bio-sensing Technologies
Institut des Sciences Analytiques
2015-2024
Centre National de la Recherche Scientifique
2013-2024
Université Claude Bernard Lyon 1
2017-2024
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2008-2017
École Normale Supérieure de Lyon
2017
CEA Marcoule
2010-2016
Institute of Environmental Biology and Biotechnology
2011-2016
Service de la Santé Publique
2016
Bioénergétique et Ingénierie des Protéines
2016
CEA Cadarache
2010-2014
Abstract Environmental cues profoundly modulate cell proliferation and elongation to inform direct plant growth development. External phosphate (Pi) limitation inhibits primary root in many species. However, the underlying Pi sensory mechanisms are unknown. Here we genetically uncouple two sensing pathways apex of Arabidopsis thaliana . First, rapid inhibition transition zone is controlled by transcription factor STOP1, its target, ALMT1 , encoding a malate channel, ferroxidase LPR1, which...
Turning over silanes: The first nanotube-based catalytic system for silane oxidation is reported (see scheme). reusable gold–nanotube hybrid cleanly oxidizes both alkyl and aryl silanes in high yields, under mild reaction conditions, compares most favorably to any other terms of overall efficacy turnover values. Detailed facts importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted by...
Palladium nanowires (of length a few tens of nanometers) are synthesized in hexagonal mesophase formed by quaternary system (Pd-doped water, surfactant, cosurfactant, and oil) electron beam irradiation. The mesophases can be doped high concentrations palladium (0.1 M) without any disturbance the structure which allows quantitative synthesis 1D Pd nanostructures. We found an increase average with amount cosurfactant (pentanol) that assists reduction/growth processes. electrocatalytic...
Homogeneous coating of carbon nanotubes with metallic nanoparticles was achieved using supramolecular auto-organization amphiphilic molecules as template. The resulting Pd nanoparticles/carbon nanotube nanohybrids were then evaluated in electrocatalysis experiments, showing superior activity ethanol oxidation compared to analogous systems.
Abstract The need to develop a blood substitute is now urgent because of the increasing concern over Europe's BSE outbreak and worldwide HIV/AIDS epidemic, which have cut supplies. Extracellular soluble hemoglobin has long been studied for its possible use as safe effective alternative transfusion, but this met with little success. Clinical trials revealed undesirable side effects–oxidative damage vasoconstriction–that hamper application cellfree substitute. We addressed these problems found...
Gold nanoparticles were deposited on carbon nanotubes to provide access a nanohybrid structure which was involved in the aerobic oxidation of alcohols. The nanohybrid-catalyzed reaction shown be highly efficient under mild conditions (i.e. room temperature, air) and selective alcohols corresponding acids or aldehydes could achieved, depending conditions.
Bones are one of the few organs in which uranyl (UO2(2+)) accumulates. This large dioxo-cation displays affinity for carboxylates, phenolates and phosphorylated functional groups proteins. The noncollagenous protein osteopontin (OPN) plays an important role bone homeostasis. It is mainly found extracellular matrix mineralized tissues but also body fluids such as milk, blood urine. Furthermore, OPN intrinsically disordered protein, which, like other proteins SIBLING family, contains a...
Uranium is a natural actinide present as uranyl U(VI) species in aqueous environments. Its toxicity considered to be chemical rather than radiotoxicological. Whatever the route of entry, reaches blood, partly eliminated via kidneys, and accumulated bones. In serum, its speciation mainly involves carbonate proteins. Direct identification labile uranyl-protein complexes extremely difficult because complexity this matrix. Thus, until now biodistribution metal serum has not been described,...
Veredelte Nanoröhren: Das erste nanoröhrenbasierte katalytische System für die Silan-Oxidation wird beschrieben (siehe Schema). wiederverwendbare Gold-Nanoröhren-Hybrid oxidiert unter milden Bedingungen sowohl Alkyl- als auch Arylsilane in hohen Ausbeuten und ist hinsichtlich Gesamteffizienz Umsatzgrad anderen katalytischen Systemen überlegen.
Background:The introduction of magnetic resonance (MR)-guided radiation treatment planning has opened a new space for theranostic nanoparticles to reduce acute toxicity while improving local control.In this work, second-generation AGuIX ® (AGuIX-Bi) are synthesized and validated.AGuIX-Bi shown maintain MR positive contrast further amplifying the dose by replacement some Gd 3+ cations with higher Z Bi .These next-generation based on platform, which is currently being evaluated in multiple...
ABSTRACT To acquire iron, Pseudomonas aeruginosa secretes the fluorescent siderophore pyoverdine (Pvd), which chelates iron and shuttles it into cells via specific outer membrane transporter FpvA. We studied role of other metals in binding transport Pvd by FpvA conclude that there is no significant affinity between metal-free Pvd. found vivo complex iron-free FpvA-Pvd fact a with aluminum (FpvA-Pvd-Al) formed from trace growth medium. When was cultured medium had been treated metal resin,...
The International Thermonuclear Experimental Reactor (ITER) is an international project aimed at the production of carbon-free energy through use thermonuclear fusion. During ITER operation, in case a loss-of-vacuum-accident, tungsten nanoparticles (W-NPs) could potentially be released into environment and induce occupational exposure via inhalation. W-NPs toxicity was evaluated on MucilAir™, 3D vitro cell model human airway epithelium. MucilAir™ exposed for 24 h to metallic ITER-like milled...
A sensitive immunoassay based on SPR analysis was developed to measure uranyl cation (UO(2)(2+)) affinity for any protein in a free state under physiological conditions. The technique involves immobilization of specific monoclonal antibody (mAb) raised against UO(2)(2+) and 1,10-phenanthroline-2,9-dicarboxylic acid (DCP) used as probe captured by the mAb. Calibration curves were established accurate determination concentrations with detection limit 7 nM. remaining could be accurately...
During long-term exposure, uranium accumulates in bone. Since U(vi) complexes shares similar coordination properties to calcium, this toxicant is assumed be exchanged with calcium ions at the surfaces of bone mineral crystals. Recently, two proteins involved turnover, fetuin A and osteopontin, were shown exhibit a high affinity for U(vi). common biochemical feature both osteopontin their inhibiting role phosphate precipitation. Therefore it conceivable that complexation these may alter...
During past decade, special focus has been laid on ultrasmall nanoparticles for nanomedicine and eventual clinical translation. To achieve such translation, a lot of challenges have to be solved. Among them, size determination is particularly tricky one. In this aim, we developed simple hyphenation between Taylor dispersion analysis inductively coupled plasma-mass spectrometry (ICP-MS). This method was proven allow the hydrodynamic radius metal-containing nanoparticles, even sizes under 5...
Comparison of click chemistry and sortagging grafting strategies for functionalizing AGuIX nanoparticles with nanobodies to develop a tri-functional technology combining MRI imaging, radiotherapy, immunotherapy by inhibiting immune checkpoints.
In the search of new robust and environmental-friendly analytical methods able to answer quantitative issues in pharmacology, we explore liquid chromatography (LC) associated with elemental mass spectrometry (ICP-MS) monitor peptides such complex biological matrices. The novelty is use replace radiolabelling radioactivity measurements, which represent up-to now gold standard measure organic compound concentrations life science. As a proof concept, choose vasopressin (AVP)/V1A receptor system...
A series of Tb-doped LaF3 nanoparticles (NPs) was prepared by systematically varying the Tb doping rate from 0 to 100%. The elemental composition confirmed inductively coupled plasma atomic emission spectroscopy (ICP-AES) analysis, and size, morphology, crystal structure were determined in solid state transmission electron microscopy X-ray diffractometry, while size ζ-potential NPs solution studied dynamic light scattering, Taylor dispersion laser Doppler electrophoresis. While appears be...