Novel carbonylated pyrazole phosphonates have been synthesized as single regioisomers by treating conjugated enones, dienones, tropone, and quinone with the Bestmann-Ohira reagent under KOH/EtOH conditions at room temperature. Through an "interrupted" version of above reaction, spiropyrazoline from arylidenecycloalkanones similar (K(2)CO(3)/EtOH) absolute regio- diastereoselectivity. The key structures were confirmed detailed spectroscopic analysis X-ray crystallography.

Gold nanoparticles were deposited on carbon nanotubes to provide access a nanohybrid structure which was involved in the aerobic oxidation of alcohols. The nanohybrid-catalyzed reaction shown be highly efficient under mild conditions (i.e. room temperature, air) and selective alcohols corresponding acids or aldehydes could achieved, depending conditions.

A one-pot, two-step, three-component method for the conversion of commercially available aldehydes to phosphonylpyrazoles has been developed, demonstrating, first time, dual reactivity Bestmann–Ohira reagent (BOR) in a single-pot transformation. This method, extended synthesis sulfonylpyrazoles by employing BOR step and diazomethyl sulfone second step, is complementary, with regard regioselectivity, previous methods such functionalized pyrazoles.

Purpose: This paper aims to test a model based on cognition, affection and behaviour theory that shows how brand love for the products are sold endorsed by Spiritual Gurus in India results formation of sacredness fidelity through trust. Methodology: The conceptual hypotheses were tested with sample 718 consumers. PLS-SEM was performed analysis using SmartPLS software(version 4.2). Findings: According result trust exerts direct positive effect love, turn, fidelity, respectively. Moreover, has...

Gold digger: The direct reductive amination of aldehydes catalyzed by gold/carbon-nanotube nanohybrids with a silane as hydride source is reported. As service to our authors and readers, this journal provides supporting information supplied the authors. Such materials are peer reviewed may be re-organized for online delivery, but not copy-edited or typeset. Technical support issues arising from (other than missing files) should addressed Please note: publisher responsible content...

Functionalized imidazoles derived from nitroallylic acetates and amidines exhibit potent activity against <italic>T. cruzi</italic>, the etiological agent of Chagas disease.

Abstract A highly efficient copper catalyzed remote C−H nitration of 8‐amidoquinolines has been developed using tert ‐butyl nitrite as nitrating agent. 5 mol% catalyst under room temperature furnished the products in excellent yields for arene, heteroarene, aliphatic carboxamide derivatives.

Abstract A general, two‐step, highly efficient synthesis of 1,2‐diaryl‐, 1,2,3‐triaryl‐, and 1,2,3,4‐tetraarylbenzenes from simple stitching α‐oxo‐ketene‐ S,S ‐acetals active methylene compounds via a lactone intermediate is described. This procedure offers easy access to functionalized arylated benzenes that contain sterically demanding groups in good excellent yields. The novelty the lies construction aromatic with desired conformational flexibility along molecular axis...

Total synthesis of all three pyrazole-based withasomnine alkaloids and selected examples their non-natural analogs has been achieved from readily available aldehydes 4-nitro-1-butanol in steps. Since turn is prepared two steps via Michael addition nitromethane to acrylate followed by borane reduction the ester group key 1,3-dipolar cycloaddition step carried out with commercially TMSCHN2, this approach a very convenient economical one.

The strong mechanical anisotropy of phosphorene combined with the atomic-scale thickness challenges commonly employed elastic continuum idealizations. Using objective boundary conditions and a density functional based potential, we directly uncover flexibility individual $\ensuremath{\alpha}$, $\ensuremath{\beta}$, $\ensuremath{\gamma}$ allotrope layers along an arbitrary bending direction. A correlation analysis in-plane elasticity finds that although monolayer cannot be defined in...

An expeditious synthesis of unsymmetrical biaryls functionalized with electron-withdrawing or -donating substituents is described and illustrated by carbanion-induced ring transformation 2H-pyran-2-one using acetyltrimethylsilane (ATMS) as a novel reagent in good yield. The novelty the reaction lies creation an aromatic from 2H-pyran-2-ones via two-carbon insertion ATMS used source carbanion.

Abstract An efficient and convenient synthesis of partially hydrogenated functionalized [5]helicenes oxa[5]helicenes, such as (1,2,5,6‐tetrahydro‐3‐oxadibenzo[ c , g ]phenanthren‐4‐ylidene)acetonitriles 6 (5,6‐dihydro‐3‐oxadibenzo[ 8 has been developed through base‐catalyzed ring transformation 5,6‐dihydro‐4‐amin‐1‐yl‐2‐oxo‐2 H ‐benzo[ h ]chromene‐3‐carbonitriles 4 with 2‐tetralones 5 . The molecular structures the oxahelicenes were examined by spectroscopic methods X‐ray crystallographic...

Functionalized N-alkyl-2-pyridones and 2-aminopyridines are useful precursors for the synthesis of various heterocyclic compounds therapeutic importance. In this paper we have delineated illustrated a direct methodology 6-aryl-N-hydroxyethyl-4-methylsulfanyl-2-pyridones through ring transformation 6-aryl-3-cyano-4-methylsulfanyl-2H-pyran-2-ones by ethanolamine. Surprisingly, analogous reaction with 6-aryl-3-cyano-4-piperidin-1-yl-2H-pyran-2-ones afforded in high yield instead corresponding...

Abstract A novel method has been developed to use ammonium tetrafluoroborate (NH 4 BF ) directly as catalyst in Biginelli reaction. new paradigm of the reaction for synthesis 3,4‐dihydropyrimidin‐2(1 H )‐ones derivatives found a novel, inexpensive, readily available, non‐toxic and mild good excellent yields. Notably, this is first time that used organic synthesis. So far, no available literature where NH catalyst. However, some reactions are with other catalysts promoters or additives. The...

In recent decades, organ-on-chip devices have gained substantial interest as an alternative for studying the pathophysiological processes relevant to drug screening. Micropumps are being utilized simulate in vivo physiological fluid flow more realistically these devices. play a crucial role pumping, perfusion, and circulation of fluids various microdevices such on-chip PCR, DNA microarrays, miniature bioreactor cell separation, lab-on-chip biosensing platforms. With rapid growth technology,...

A novel microfluidic-device for water disinfection via diverse physiochemical effects has been demonstrated.

Originating in China during December 2019, the novel corona-virus, SARS-CoV-2, has created mayhem worldwide a very short time. The outbreak been so rapid and widespread that only option to treat patients was administering drugs already available market like chloroquine/hydroxychloroquine (an antimalarial drug) remedesivir. A large number of have cured but attribution survival by these controversial. Till date, we do not any specific drug or vaccine for COVID-19 pandemic seems be far from...

U or C-shaped waveguides, coupled to analyte microchannels, have been shown be very responsive evanescent-wave-absorption-based sensing. However, due only having a single C-bend length, for interaction in earlier devices, there was always an opportunity advance their evanescent-absorbance sensitivity, by including multiple structures (interfaced with the microchannel system) device design. To achieve this objective, two different types of waveguide probes (having orientation C-bends), i.e....