A5073700342- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthesis and Biological Evaluation
- Bioactive Compounds and Antitumor Agents
- Synthesis and biological activity
- Click Chemistry and Applications
- Cyclopropane Reaction Mechanisms
- Cancer therapeutics and mechanisms
- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Synthesis and Characterization of Heterocyclic Compounds
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Microbial Natural Products and Biosynthesis
- Bacterial biofilms and quorum sensing
- Chemical Synthesis and Reactions
- Synthesis of Tetrazole Derivatives
- Multicomponent Synthesis of Heterocycles
- Microwave-Assisted Synthesis and Applications
- Nanoplatforms for cancer theranostics
- Synthesis of Organic Compounds
- Synthesis and Reactions of Organic Compounds
- Catalytic C–H Functionalization Methods
- Synthesis and Catalytic Reactions
- Phenothiazines and Benzothiazines Synthesis and Activities
- Plant-Microbe Interactions and Immunity
Universidade Federal de Minas Gerais
2014-2021
Universidade Federal Rural de Pernambuco
2012-2016
Universidade do Estado de Minas Gerais
2016
Sintetica (Switzerland)
2015
Centro Universitário de Belo Horizonte
2015
1,2,3-Triazole-, arylamino- and thio-substituted naphthoquinones (24, 8, 2 representatives, respectively) were synthesized in moderate yields evaluated against several human cancer cell lines (blood, ovarian, breast, central nervous system, colon, prostate cancers melanoma), showing, for some of them, IC50 values below μM. The cytotoxic potential the tested was also assayed on non-tumor cells such as peripheral blood mononucluear (PBMC) two murine fibroblast (L929 V79 cells). α-Lapachone-...
In continuation of our quest for new redox-modulating catalytic antitumor molecules, selenium-containing quinone-based 1,2,3-triazoles were synthesized using rhodium-catalyzed C-H bond activation and click reactions. All compounds evaluated against five types cancer cell lines: HL-60 (human promyelocytic leukemia cells), HCT-116 colon carcinoma SF295 glioblastoma NCIH-460 lung cells) PC3 prostate cells). Some showed good activity with IC50 values below 1 µM. The cytotoxic potential the...
In our continued search for novel trypanocidal compounds, twenty-six derivatives of para- and ortho-naphthoquinones coupled to 1,2,3-triazoles were synthesized. These compounds evaluated against the infective bloodstream form Trypanosoma cruzi, etiological agent Chagas disease. Compounds 17-24, 28-30 36-38 are described herein first time. Three these (28-30) found be more potent than standard drug benznidazole, with IC50/24h values between 6.8 80.8μM. Analysis toxicity heart muscle cells led...
One-pot cascade reactions of amidines with nitroallylic acetates and α-bromonitroalkenes provide functionalized imidazoles that exhibit trypanocidal activity.
Functionalized imidazoles derived from nitroallylic acetates and amidines exhibit potent activity against <italic>T. cruzi</italic>, the etiological agent of Chagas disease.
New quinoidal compounds were prepared and evaluated against <italic>T. cruzi</italic> cancer cell lines for the identification of new bioactive agents.
Abstract Quinone‐based N ‐sulfonyl‐1,2,3‐triazoles were synthesized by click chemistry and subsequently evaluated against eight types of cancer cell lines. Some the compounds exhibited potent cytotoxicity with IC 50 values < 1.0 μM. Also, cytotoxic potential quinones was peripheral blood mononuclear (PBMC) V79 cells. Additionally, chemical reactivity Rh(II) aza‐vinyl carbenes generated in situ from these triazoles studied. These could provide promising new lead derivatives for more...
Fifteen naphthoquinones, sixteen phenazines and fifteen aryl triazoles were synthesized evaluated against Mycobacterium tuberculosis.Twenty five substances are reported here for the first time and, among all of compounds evaluated, six presented MIC (minimal inhibitory concentration) values ≤ 6.25 μg mL -1 .These promising antimycobacterial prototypes.
A series of 1,2,3-triazole derivatives was synthesized from N-phthalimidoalkyl-azides (A1 -A4) and alkynes (a-e) under ultrasound irradiation in the presence CuI, Et3N DMF as solvent. The present protocol afforded 18 new 1,2,3-triazoles (1-4) good-to-excellent yields (67-98%).
We report the synthesis of 47 new quinone-based derivatives via click chemistry and their subsequent evaluation against cancer cell lines control L929 murine fibroblast line. These compounds combine two redox centers, such as an ortho-quinone/para-quinone or quinones/selenium with 1,2,3-triazole nucleus. Several these present IC50 values below 0.5 μM in significantly lower cytotoxicity line good selectivity index. Hence, our study confirms use a complete very diverse range quinone potential...
A convenient, efficient and fast acetylation combining clays ultrasound irradiation is described.Some molecules from nature or synthetic source, i.e., D-glucose, glycerol, D-mannitol 1,2,3-triazolic derivatives such as N-glucosyl sugars 2-substituted 1,4-naphthoquinone structures were acetylated.This kind of chemistry may be classified eco-friendly because the reactions take a short time catalyst reusable.
Click chemistry-based strategies for the synthesis of 2-amino-alkyl-1,2,3-triazole-1,4naphthoquinone derivatives make it possible to obtain desired products from 1,4-naphthoquinone (1,4-NQ), and bio-based lawsone, nor-lapachol lapachol.The first route (Strategy A) starting 1,4-NQ amino alcohols, then 2-amino-alkyl-1,4-NQ were tosylated.The azide ion displaced tosylate group afford 2-azide-alkyl-1,4-NQ, which was submitted a copper-catalyzed alkyne cycloaddition (CuAAC) condition.The...
Abstract Cascade reactions of amidines (II) with title compounds (I) and (IV) afford 2,4,5‐trisubstituted 2,4‐disubstituted imidazoles (III), (V), (VI), respectively.
Abstract Compound (IIId) shows better and compounds (IIIe) (IIIf) show similar activity against Trypanosoma cruzi compared with the reference benznidazole.