A5040111764- Research on Leishmaniasis Studies
- Synthesis and Biological Evaluation
- Immunotherapy and Immune Responses
- Essential Oils and Antimicrobial Activity
- SARS-CoV-2 and COVID-19 Research
- Hepatitis Viruses Studies and Epidemiology
- Eosinophilic Disorders and Syndromes
- Toxin Mechanisms and Immunotoxins
- Natural product bioactivities and synthesis
- Phytochemicals and Antioxidant Activities
- Burkholderia infections and melioidosis
- vaccines and immunoinformatics approaches
- T-cell and B-cell Immunology
- Transgenic Plants and Applications
- Phytochemistry and Biological Activities
- Garlic and Onion Studies
- Trypanosoma species research and implications
- Ethnobotanical and Medicinal Plants Studies
- Monoclonal and Polyclonal Antibodies Research
- Herpesvirus Infections and Treatments
- Bioactive Compounds and Antitumor Agents
- Parasites and Host Interactions
- Paraoxonase enzyme and polymorphisms
Université Paris-Saclay
2020-2022
Centre National de la Recherche Scientifique
2019-2022
Laboratoire des Biomolécules
2021
Centre d'Immunophénomique
2021
Centre d’Immunologie de Marseille-Luminy
2021
University College Cork
2021
Universidade Federal de Minas Gerais
2013-2020
Université Paris-Sud
2020
Abstract The development of formulations that maintain the biological and physical chemistry properties essential oils is an important choice when they are used as active ingredient. This study aimed to characterize oil from leaves Cymbopogon densiflorus evaluate antioxidant activity oil, produce a nanoemulsion formulation containing it. was obtained by hydrodistillation, seasonality analysed every 2 months gas chromatography–mass spectrometry, showing more than 90% composition maintained...
The physicochemical characteristics of nanostructured suspensions are important prerequisites for the success new drug development. This work aimed to develop nanometric systems containing Cymbopogon densiflorus leaf essential oil and evaluate their antimicrobial activity. was isolated by hydrodistillation from leaves analyzed GC-MS. main constituents were found be trans-p-mentha-2,8-dien-1-ol, cis-p-mentha-2,8-dien-1-ol, trans-p-mentha-1(7),8-dien-2-ol, cis-piperitol,...
There is no safe and efficacious vaccine against human leishmaniasis available live attenuated vaccines have been used as a prophylactic alternative the disease. In order to obtain an Leishmania parasite for purposes, we generated L. infantum KHARON1 (KH1) null mutants (ΔLikh1). This gene was previously associated with growth defects in mexicana. ΔLikh1 obtained confirmed by PCR, qPCR Southern blot. We also generate KH1 complemented line introduction of episomal copies KH1. Although...
Visceral leishmaniasis is a protozoan disease associated with high fatality rate in developing countries. Although the drug pipeline constantly improving, available treatments are costly and live-threatening side effects not uncommon. Moreover, an approved vaccine against human does exist yet. Using whole antigens from Leishmania donovani promastigotes (LdAg), we investigated protective potential of novel adjuvant-free strategy. Immunization mice LdAg via intradermal or intranasal route...
There is a great need for orally active drugs the treatment of neglected tropical disease leishmaniasis. Amphiphilic Sb(V) complexes, such as 1:3 Sb-N-octanoyl-N-methylglucamide complex (SbL8), are promising drug candidates. It has been previously reported that SbL8 forms kinetically stabilized nanoassemblies in water and this simple dispersion exhibits antileishmanial activity when given by oral route to murine model visceral The main objective present work was interfere structural...
Adenovirus-based vaccines are demonstrating promising clinical potential for multiple infectious diseases, including COVID-19. However, the immunogenicity of vector itself decreases its effectiveness as a boosting vaccine due to induction strong anti-vector neutralizing immunity. Here we determined how dissolvable microneedle patches (DMN) skin immunization can overcome this issue, using clinically-relevant adenovirus-based Plasmodium falciparum malaria vaccine, AdHu5–PfRH5, in mice....
The main avenue for the development of an HIV-1 vaccine remains induction protective antibodies. A rationale approach is to target antigen specific receptors on dendritic cells (DC) via fused monoclonal antibodies (mAb). In mouse and non-human primate models, targeting skin Langerhans (LC) with anti-Langerin mAbs Gag drives antigen-specific humoral responses. these immunization strategies in humans requires a better understanding early immune events driven by human LC. We therefore produced...
ABSTRACT Adenovirus-based vaccines are demonstrating promising clinical potential for multiple infectious diseases including COVID-19. However the immunogenicity of vector itself decreases its effectiveness as a boosting vaccine due to induction strong anti-vector neutralising immunity. Here we determined how dissolvable microneedle patches (DMN) skin immunization can overcome this issue, using clinically-relevant adenovirus-based Plasmodium falciparum malaria vaccine, AdHu5-PfRH5, in mice....
This work aims to evaluate whether nanoassemblies (NanoSb) made from antimony(V) complexes with octanoyl-N-methylglucamide (SbL8) or decanoyl-N-methylglucamide (SbL10) would effectively target the infection sites in visceral and cutaneous leishmaniases (VL CL). NanoSb were investigated regarding stability at different pHs, accumulation of Sb macrophage host cell liver, vitro vivo activities models leishmaniasis. The kinetic assay showed that are stable neutral pH, but release incorporated...