A5104341711- Research on Leishmaniasis Studies
- Insect Pest Control Strategies
- Nanoparticles: synthesis and applications
- Crystallization and Solubility Studies
- Synthesis and Biological Evaluation
- X-ray Diffraction in Crystallography
- Synthesis and biological activity
- Essential Oils and Antimicrobial Activity
- Crystallography and molecular interactions
- Phytochemistry and Bioactivity Studies
- Phytochemicals and Antioxidant Activities
- Chemical synthesis and pharmacological studies
- Moringa oleifera research and applications
- Trypanosoma species research and implications
- Pneumonia and Respiratory Infections
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Pharmacology and Obesity Treatment
- Parasites and Host Interactions
- Organometallic Compounds Synthesis and Characterization
- Bioactive Natural Diterpenoids Research
- Microbial Metabolic Engineering and Bioproduction
- Mycobacterium research and diagnosis
- Hibiscus Plant Research Studies
- vaccines and immunoinformatics approaches
International Islamic University, Islamabad
2019-2025
Lady Reading Hospital
2021-2025
Universidade Federal de Minas Gerais
2012-2024
Noakhali Science and Technology University
2020-2021
Universidade Federal de Ouro Preto
2016
Two novel organoantimony(V) and two organobismuth(V) complexes of the type ML2 were synthesized, with L = acetylsalicylic acid (HL1) or 3-acetoxybenzoic (HL2) M triphenylantimony(V) (M1) triphenylbismuth(V) (M2). Complexes, [M1(L1)2] (1), [M1(L2)2]∙CHCl3 (2), [M2(L1)2], (3) [M2(L2)2] (4), characterized by elemental analysis, IR NMR. Crystal structures dicarboxylate 1 2 determined single crystal X-ray diffraction. Structural analyses revealed that adopt five-coordinated extremely distorted...
Phytoextracts modulated synthesis of nano‐scaled spherical lanthanum oxide nanoparticles (La 2 O 3 NPs) are reported using the aqueous extracts Hyphaene thebaica as a bioreducing and chelating agent. X‐ray diffraction (XRD) pattern revealed sharp peaks single‐phase purity. The Debye–Scherrer approximation indicated an average crystallite size 37 nm, whereas W‐H plot 59 complemented by high‐resolution transmission electron microscopy (HR‐TEM). infrared spectroscopy characteristic La‐O band at...
Corynebacterium pseudotuberculosis (Cp) is a pathogenic bacterium that causes caseous lymphadenitis (CLA), ulcerative lymphangitis, mastitis, and edematous to broad spectrum of hosts, including ruminants, thereby threatening economic dairy industries worldwide. Currently there no effective drug or vaccine available against Cp. To identify new targets, we adopted novel integrative strategy, which began with the prediction modelome (tridimensional protein structures for proteome an organism,...
Background: Crimean-Congo hemorrhagic fever virus (CCHFV) poses a substantial public health threat, particularly in Khyber Pakhtunkhwa, Pakistan, where its prevalence and epidemiological distribution remain inadequately documented. This study investigated the epidemiology, prevalence, transmission dynamics of 2023 CCHFV outbreak Pakhtunkhwa province, during Eid-ul-Adha season.Methods: A total 109 suspected cases were enrolled from April to July 2023. Laboratory confirmation was performed...
ABSTRACT Leishmaniasis, caused by protozoan parasites of the genus Leishmania , affects nearly 12 million people annually worldwide, and has limited, highly toxic therapeutic options. This study reports synthesis, in vitro silico evaluations four novel antimony complexes ( 3a‐3d ) as potent safe antileishmanial agents. The were synthesized using Sb‐salts with different phenolic ligands characterized elemental analysis, FT‐IR NMR spectroscopic techniques. Structural parameters further...
Synergistic combinations of various antimicrobial agents are considered ideal strategies in combating clinical and multidrug resistant (MDR) infections. In this study, antibacterial potential Jatropha curcas crude seed extracts, oil, commercially available antibiotics, their were investigated for synergistic effect against clinical, MDR ATCC bacterial strains by agar well diffusion assay. Methanolic extracts remained more active Staphylococcus aureus (ATCC), with zone inhibition (ZOI) 21 mm,...
The Actinobacteria, Corynebacterium pseudotuberculosis strain P54B96, a nonmotile, non-sporulating and mesophile bacterium, was isolated from liver, lung mediastinal lymph node lesions in an antelope South Africa. This is interesting the sense that it has been found together with non-tuberculous mycobacteria (NTMs) which could nevertheless play role lesion formation. In this work, we describe set of features C. details complete genome sequence annotation. comprises 2.34 Mbp long, single...
Previous studies have shown that the association of drug meglumine antimoniate (MA) with β-cyclodextrin can improve its bioavailability by oral route. In this work, ribose and maltose were investigated for their ability to form mixed or complexes MA, release MA modulate serum levels Sb after administration in mice. Analysis MA/ribose composition high performance liquid chromatography coupled mass spectrometry (LCMS-IT-TOF) revealed presence meglumine-Sb-ribose Sb-ribose complexes. MA/maltose...
Aim: To investigate the photodynamic therapeutic potential of ferromagnetic iron oxide nanorods (FIONs), using Trigonella foenum-graecum as a reducing agent, against Leishmania tropica. Materials & methods: FIONs were characterized ultraviolet visible spectroscopy, x-ray diffraction and scanning electron microscopy. Results: showed excellent activity L. tropica promastigotes amastigotes (IC50 0.036 ± 0.003 0.072 0.001 μg/ml, respectively) upon 15 min pre-incubation light-emitting diode light...
Our present study was designed to investigate the comparative anti-obesity efficacy of ethanolic extract Azadirachta indica A. Juss., Trigonella foenum-graecum L., Allium sativum L. and Zingiber officinale Roscoe in high fat-induced mice with their total phenolic flavonoid profile. Total content were determined by Folin–Ciocalteu's Aluminium chloride UV method respectively. In our study, 55 healthy separated into 11 groups take respective treatments. Lipid uric acid profile estimated using...
Zinc oxide (ZnO) and magnesium-doped zinc (Mg-doped ZnO) nanoparticles (NPs) were synthesized using <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Ziziphus oxyphylla</i> 's aqueous leaf extract as reducing agent. UV-Vis absorption peaks at 324 nm 335 indicative of ZnO Mg-doped ZnO, respectively. FTIR bands observed 3238, 1043, 1400, 1401, 2186 2320 cm <sup xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> suggested the presence phenols,...
With the growing demand for vegetable oils, alternative non-edible feedstocks like Jatropha curcas seed oil have gained interest biodiesel production. The study aimed to comprehensively evaluate physicochemical properties and production potential of locally produced J. seeds in Pakistan. Two different approaches were applied: a chemical synthesis approach involving acidic pretreatment alkaline transesterification, biosynthetic using lipase-producing strain Bacillus subtilis Q5 strain....
Progress toward the improvement of meglumine antimoniate (MA), commercially known as Glucantime, a highly effective but also toxic antileishmanial drug, has been hindered by lack knowledge and control its chemical composition. Here, MA was manipulated chemically with aim achieving an orally drug. compounds were synthesized from either antimony pentachloride (MA-SbCl5) or potassium hexahydroxyantimonate [MA-KSb(OH)6] prepared under low polymerization state. These compared to Glucantime...
Aim: Amphotericin B (AmB) is an antileishmanial drug with high toxicity; however, this drawback might overcome by decreasing the AmB self-aggregation state. This work aimed at evaluating influence of cholesterol on aggregation state loaded in a nanoemulsion (NE-AmB) for treatment cutaneous leishmaniasis. NE-AmB (1, 4 and 8 mg/kg/day) was administered intravenously to animals infected Leishmania major every 2 days total five injections. Results: Ultraviolet-visible spectroscopy circular...
Abstract The current study was carried out to compare the antileishmanial potential of characterized chemically and plant mediated ( Trigonella foenum-graecum ) FeO-NPs (FeO-NPs) against L.tropica KWH23. promastigotes amastigotes mortality, ROS generation, biocompatibility assessment were estimated in time-dose dependent manner by PDT. LED exposed bio-inspired after 72 hours, express significant suppressive effects exhibiting 50% inhibitory concentration (IC 50 0.001572±0.02μg/ml...
Herein, we report the green synthesis of silver nanoparticles using aqueous extract root Angilica glauca Edgew. UV-vis and FT-IR spectroscopies, X-ray diffraction analysis scanning electron microscopy technique were employed to structurally morphologically characterize synthesized nanoparticles. The found be spherical in shape with an average size ∼21 nm. was rich phenolic flavonoid contents. Both extract-loaded inhibited growth both Pseudomonas aeruginosa (inhibition zone 13.0 ± 1.6 4.0 0.9...